INT94827

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 24
Total Number 30
Disease Relevance 26.11
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HBS1L) translation (HBS1L) GTPase activity (HBS1L)
Anatomy Link Frequency
blood 2
liver 1
B lymphocyte 1
pallidum 1
HBS1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 122 100.00 Very High Very High Very High
antagonist 1 97.72 Very High Very High Very High
Pain 29 96.68 Very High Very High Very High
cva 7 93.36 High High
nud 1 92.28 High High
depression 2 91.28 High High
Inflammatory marker 2 89.64 High High
abdominal pain 6 88.52 High High
analgesia 8 82.56 Quite High
Perioperative pain 8 80.44 Quite High
Disease Link Frequency Relevance Heat
Hepatitis 83 100.00 Very High Very High Very High
Hepatitis C Virus Infection 43 100.00 Very High Very High Very High
Arsenic Poisoning 1 99.92 Very High Very High Very High
Sickle Cell Anemia 204 99.80 Very High Very High Very High
Thalassemia 434 99.76 Very High Very High Very High
Hepatitis B Virus Infection 147 99.52 Very High Very High Very High
Toxoplasmosis 1 99.10 Very High Very High Very High
Hemoglobinopathy 11 99.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 124 98.78 Very High Very High Very High
Hepatocellular Cancer 13 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After pre-treatment of samples (faeces and biopsies) with a liquid medium (trypticase soy broth-TSB) containing foetal calf serum (FCS, 10%) and spectinomycin and rifampicin (TSB-SR) the first detection of B. aalborgi isolate HBS1 was observed after 48 h in the primary plates of selective blood agar modified medium (BAM) containing spectinomycin and rifampicin (BAM-SR), where growth zones were signalled by a small weakly beta-haemolytic halo.
Gene_expression (detection) of HBS1 in blood
1) Confidence 0.67 Published 2003 Journal Res. Microbiol. Section Abstract Doc Link 12648729 Disease Relevance 0.41 Pain Relevance 0.09
The genotype frequencies of AS (HbS heterozygote) were 9.9% (N?
Gene_expression (heterozygote) of HbS
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894056 Disease Relevance 0.42 Pain Relevance 0
HBsAg was detected in serum in 1990 when he voluntarily donated blood.
Gene_expression (detected) of HBsAg in blood
3) Confidence 0.36 Published 2006 Journal World J. Gastroenterol. Section Abstract Doc Link 16610011 Disease Relevance 1.34 Pain Relevance 0.05
The allele frequency of the S allele was found to be high in both populations (0.25 in Hausa and 0.20 for Massalit) which was rather surprising for the Massalit, a group indigenous to Darfur of western Sudan where we [10,11] and others [12], have indicated based on analysis of the HbS haplotypes and other markers, a recent introduction of HbS into Sudan and the Eastern Sahel.
Gene_expression (introduction) of HbS
4) Confidence 0.22 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829010 Disease Relevance 0.68 Pain Relevance 0
A total of 546 individuals (261 from Hausa and 285 from Massalit) were screened for the normal haemoglobin HbA and haemoglobin HbS variants.
Gene_expression (screened) of HbS
5) Confidence 0.22 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829010 Disease Relevance 1.14 Pain Relevance 0.08
The simulated frequencies of HbA and HbS alleles for Massalit, reached equilibrium (0.52 for HbA and0.48 for HbS) in the fourth generation(Figure 2).
Gene_expression (alleles) of HbS
6) Confidence 0.22 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829010 Disease Relevance 0.57 Pain Relevance 0
Here, we report the clinical and hematologic presentation and molecular pathology of these HbS-?
Gene_expression (presentation) of HbS
7) Confidence 0.20 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 0.75 Pain Relevance 0
Recently, it has also been shown that HbS-?
Gene_expression (shown) of HbS
8) Confidence 0.20 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 1.30 Pain Relevance 0
Earlier studies from Orissa showed that HbS-?
Gene_expression (showed) of HbS
9) Confidence 0.20 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 1.42 Pain Relevance 0
The present study was undertaken to determine the genetic factors responsible for the clinical variability of HbS-?
Gene_expression (variability) of HbS
10) Confidence 0.20 Published 2010 Journal Indian Journal of Human Genetics Section Abstract Doc Link PMC3009427 Disease Relevance 0.94 Pain Relevance 0
thalassemia mutations on the clinical severity of HbS-?
Gene_expression (severity) of HbS associated with thalassemia
11) Confidence 0.20 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 1.41 Pain Relevance 0
The phenotypic expression of HbS-?
Gene_expression (expression) of HbS
12) Confidence 0.18 Published 2010 Journal Indian Journal of Human Genetics Section Abstract Doc Link PMC3009427 Disease Relevance 1.01 Pain Relevance 0
We conclude that the clinical manifestations of Indian HbS-?
Gene_expression (manifestations) of HbS
13) Confidence 0.17 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009427 Disease Relevance 0.53 Pain Relevance 0
It is effective in inducing HBs antibody production by increasing T and B lymphocyte responsiveness, probably through facilitating a greater contact with the antigen overtime [20-22].
Gene_expression (production) of HBs in B lymphocyte
14) Confidence 0.15 Published 2006 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1540413 Disease Relevance 0.78 Pain Relevance 0
Heterozygous sickle cell carriers produce both HbS and normal HbA and are usually asymptomatic [1].
Gene_expression (produce) of HbS associated with sickle cell anemia
15) Confidence 0.06 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2838918 Disease Relevance 1.16 Pain Relevance 0
Serological tests revealed that 1,884 (4.4%) of individuals were positive for hepatitis B surface antigen (HBsAg), 737 (1.7%) for Treponema pallidum hemagglutination (TPHA) and only 83 (0.2%) for antibody to human immunodeficiency virus (anti-HIV).
Gene_expression (positive) of HBsAg in pallidum associated with acquired immune deficiency syndrome or hiv infection and hepatitis
16) Confidence 0.06 Published 2000 Journal Southeast Asian J. Trop. Med. Public Health Section Abstract Doc Link 11289023 Disease Relevance 0.84 Pain Relevance 0.23
SCD is a haemoglobinopathy characterized by an abnormal haemoglobin variant termed haemoglobin S (HbS).
Gene_expression (termed) of HbS associated with sickle cell anemia and hemoglobinopathy
17) Confidence 0.05 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2838918 Disease Relevance 1.07 Pain Relevance 0.12
The degree to which HbS is reduced seems to generally correlate with reduced complication rates [9].
Gene_expression (reduced) of HbS
18) Confidence 0.05 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2838918 Disease Relevance 0.52 Pain Relevance 0.36
This mutation leads to the synthesis of HbS, in which the hydrophobic valine at position 6 of the 146-amino acid haemoglobin protein is replaced by the hydrophilic amino acid glutamine.
Gene_expression (synthesis) of HbS
19) Confidence 0.05 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2838918 Disease Relevance 0.62 Pain Relevance 0
Anti-HBsAg titres measured in mIU/mL were expressed as geometric mean titres (GMT) for each group.
Gene_expression (expressed) of HBsAg
20) Confidence 0.04 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.07 Pain Relevance 0

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