INT9483

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 34
Total Number 38
Disease Relevance 3.24
Pain Relevance 12.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Junb) nucleus (Junb) DNA binding (Junb)
Anatomy Link Frequency
brain 4
striatum 3
ACe 3
cerebral hemispheres 1
CPu 1
Junb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 15 99.84 Very High Very High Very High
Morphine 47 99.82 Very High Very High Very High
opioid receptor 20 99.82 Very High Very High Very High
Enkephalin 13 99.80 Very High Very High Very High
halothane 20 99.72 Very High Very High Very High
withdrawal 6 99.56 Very High Very High Very High
Somatostatin 4 99.56 Very High Very High Very High
antagonist 27 99.32 Very High Very High Very High
Central nervous system 4 99.32 Very High Very High Very High
qutenza 16 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 13 99.62 Very High Very High Very High
Ganglion Cysts 10 99.44 Very High Very High Very High
Urological Neuroanatomy 4 98.40 Very High Very High Very High
Shock 40 97.76 Very High Very High Very High
Drug Dependence 3 96.28 Very High Very High Very High
Colitis 3 96.16 Very High Very High Very High
INFLAMMATION 2 95.48 Very High Very High Very High
Opiate Addiction 1 94.36 High High
Morphine Dependence 2 89.60 High High
Aids-related Complex 3 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of pentobarbital and halothane anesthesia on the expression in brain of the immediate-early genes c-fos and jun-B were investigated.
Gene_expression (expression) of jun-B in brain associated with anesthesia and halothane
1) Confidence 0.78 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1642355 Disease Relevance 0 Pain Relevance 0.26
Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain.
Gene_expression (expression) of jun-B in brain associated with halothane
2) Confidence 0.78 Published 1992 Journal Anesthesiology Section Title Doc Link 1642355 Disease Relevance 0 Pain Relevance 0.28
At 1 mg/kg, MDL 72222 both induced JunB expression and potentiated the response induced by morphine.
Gene_expression (expression) of JunB associated with morphine
3) Confidence 0.78 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838105 Disease Relevance 0 Pain Relevance 1.04
Morphine also induced JunB expression in the same region of the dorsomedial CPu.
Gene_expression (expression) of JunB in CPu associated with morphine
4) Confidence 0.78 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838105 Disease Relevance 0 Pain Relevance 1.03
The present results demonstrate that neurotransmitters released from splanchnic nerve terminals induce expression of c-fos, c-jun, and junB in adrenal chromaffin cells which results in increased AP-1 DNA binding activity.
Gene_expression (expression) of junB associated with neurotransmitter
5) Confidence 0.75 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.53
To determine if the periaqueductal gray (PAG) and the dorsal raphe nucleus (DRN) are involved in morphine-induced c-Fos and JunB expression in the caudate-putamen (CPu), the mu receptor antagonist, beta-funaltrexamine (beta-FNA), was unilaterally infused into the PAG adjacent to DRN prior to morphine.
Gene_expression (expression) of JunB in DRN associated with antagonist, raphe, central grey and morphine
6) Confidence 0.74 Published 1999 Journal Brain Res. Section Abstract Doc Link 10526114 Disease Relevance 0.29 Pain Relevance 0.95
Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine.
Gene_expression (expression) of junB in striatum associated with enkephalin
7) Confidence 0.72 Published 1995 Journal J. Neurosci. Section Title Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.13
The effect of a single injection of caffeine on the expression of c-fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied.
Gene_expression (expression) of junB in striatum
8) Confidence 0.72 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0
This was somewhat consistent with a previous study of JunB expression (Strekalova et al., 2003), and was suggestive that context re-exposure does engage memory reconsolidation.
Gene_expression (expression) of JunB
9) Confidence 0.72 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2991235 Disease Relevance 0.17 Pain Relevance 0.11
Vibratome-cut sections were immunostained for the detection of c-fos, JunB, Krox 24, somatostatin, substance P, dynorphin, tyrosine hydroxylase, and enkephalin.
Gene_expression (detection) of JunB associated with dynorphin, somatostatin, enkephalin and substance p
10) Confidence 0.69 Published 1994 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7621502 Disease Relevance 0 Pain Relevance 0.41
Cryostat-cut sections from the caudate were immunostained for the detection of c-fos, JunB, and Krox 24, as well as in situ hybridization for proenkephalin mRNA.
Gene_expression (detection) of JunB
11) Confidence 0.69 Published 1994 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7621502 Disease Relevance 0 Pain Relevance 0.44
Stress caused an intense expression of c-fos, c-jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN.
Gene_expression (expression) of junB in ACe associated with stress
12) Confidence 0.68 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.34 Pain Relevance 0.13
Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain.
Gene_expression (expression) of jun-B in brain associated with halothane
13) Confidence 0.68 Published 1992 Journal Anesthesiology Section Title Doc Link 1642355 Disease Relevance 0 Pain Relevance 0.28
Acute injection of morphine induces expression of the immediate-early genes c-Fos and JunB in several forebrain regions of the rat, in part through an N-methyl-D-aspartate (NMDA) receptor-dependent mechanism.
Gene_expression (expression) of JunB in forebrain associated with morphine
14) Confidence 0.61 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809699 Disease Relevance 0 Pain Relevance 0.51
The messenger ribonucleic acid transcription products of the genes c-fos, jun-B, and beta-actin from whole cerebral hemispheres were analyzed autoradiographically after Northern blot hybridization with 32P-labeled deoxyribonucleic acid probes.
Spec (analyzed) Gene_expression (products) of jun-B in cerebral hemispheres
15) Confidence 0.60 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1642355 Disease Relevance 0 Pain Relevance 0.19
Relative levels of c-fos and jun-B messenger ribonucleic acid were determined from optical density measurements of the autoradiographic bands, with beta-actin measurements being used to correct for sample-to-sample variation.
Spec (determined) Gene_expression (levels) of jun-B in bands
16) Confidence 0.60 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1642355 Disease Relevance 0 Pain Relevance 0.10
The present paper describes the effect of capsaicin-induced stressful stimulus on the expression of immediate early genes (IEGs) c-fos, c-jun, junB and junD in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (ACe) using in situ hybridization.
Gene_expression (expression) of junB in nucleus associated with qutenza
17) Confidence 0.59 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.30 Pain Relevance 0.13
However, the same studies demonstrated that high concentrations of propofol did not affect the expression of c-Fos, JunB or Egr-1 in culture [12,13].
Gene_expression (expression) of JunB
18) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.21 Pain Relevance 0.43
In contrast, Kozinn and co-workers showed that propofol regulates the expression of c-Fos in hippocampal slices via inhibition of N-methyl-D-aspartate (NMDA) receptor activation of the extracellular signal-regulated kinase (ERK) pathway [14,15], while Hamaya et al reported that propofol increases the expression of c-Fos and Jun B in the rat brain [16].
Gene_expression (expression) of Jun B in brain
19) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.07 Pain Relevance 0.35
The expressions of c-JUN, JUN B, c-FOS FOS B and KROX-24 proteins were investigated by immunocytochemistry following the application of formalin (5%, 50 microliters) into the plantar skin of one hindpaw.
Spec (investigated) Gene_expression (expressions) of JUN B in skin
20) Confidence 0.39 Published 1993 Journal Neuroscience Section Abstract Doc Link 8100045 Disease Relevance 0 Pain Relevance 0.23

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