INT94833

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Context Info
Confidence 0.53
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.01
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FGF1) cytoplasm (FGF1) cytosol (FGF1)
extracellular space (FGF1) signal transduction (FGF1) extracellular region (FGF1)
Anatomy Link Frequency
fibroblasts 2
pericardial fluid 1
FGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 10 99.72 Very High Very High Very High
Inflammation 80 99.50 Very High Very High Very High
Duloxetine 1 93.40 High High
cytokine 2 90.16 High High
Adalimumab 1 85.22 High High
abatacept 1 84.80 Quite High
pregabalin 1 78.92 Quite High
Angina 2 59.48 Quite High
psoriasis 1 50.92 Quite High
Tendonitis 1 34.48 Quite Low
Disease Link Frequency Relevance Heat
Hepatitis B Virus Infection 1 100.00 Very High Very High Very High
Influenza In Birds 1 99.98 Very High Very High Very High
Coronary Artery Disease 9 99.72 Very High Very High Very High
INFLAMMATION 82 99.50 Very High Very High Very High
Stress 5 97.68 Very High Very High Very High
Necrosis 2 91.16 High High
Cancer 11 90.80 High High
Coronary Stenosis 1 90.76 High High
Hypoxia 4 76.40 Quite High
Emergencies 1 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid.
Gene_expression (expression) of acidic fibroblast growth factor in pericardial fluid associated with coronary artery disease and ischemia
1) Confidence 0.53 Published 2000 Journal Heart Vessels Section Title Doc Link 11289498 Disease Relevance 0.53 Pain Relevance 0.25
Gateways to clinical trials.

(+)-Dapoxetine hydrochloride, (R)-Etodolac; Abatacept, ABT-510, Adalimumab, Agatolimod sodium, Alemtuzumab, Alvocidib hydrochloride, Aminolevulinic acid methyl ester, Aripiprazole, AS01B, AS02B, AS02V, Azacitidine; Becatecarin, Bevacizumab, Bevirimat, Bortezomib, Bremelanotide; CAIV-T, Canfosfamide hydrochloride, CHR-2797, Ciclesonide, Clevidipine; Darbepoetin alfa, Decitabine, Degarelix acetate, Dendritic cell-based vaccine, Denosumab, Desloratadine, DMXB-Anabaseine, Duloxetine hydrochloride, Dutasteride; Ecogramostim, Eicosapentaenoic acid/docosahexaenoic acid, Eletriptan, Enzastaurin hydrochloride, Erlotinib hydrochloride, Escitalopram oxalate, Etoricoxib, Everolimus, Ezetimibe, Ezetimibe/simvastatin; Ferumoxytol, Fesoterodine fumarate, Fulvestrant; Gefitinib, GM-CSF DNA, GSK-690693; H5N1 avian flu vaccine, Hepatitis B hyperimmunoglobulin, Human Fibroblast Growth Factor 1, Hypericin-PVP; Icatibant acetate, Iclaprim, Immunoglobulin intravenous (human), Ipilimumab, ISS-1018; L19-IL-2, Lapuleucel-T, Laropiprant, Liposomal doxorubicin, LP-261, Lumiracoxib, LY-518674; MDV-3100, MGCD-0103, Mirabegron, MyoCell; NASHA/Dx, Niacin/laropiprant; O6-Benzylguanine, Ocrelizumab, Olmesartan medoxomil, Omalizumab; P-276-00, Paclitaxel nanoparticles, Paclitaxel nanoparticles, Padoporfin, Paliperidone, PAN-811, Pegaptanib octasodium, Pegfilgrastim, Pemetrexed disodium, PF-00299804, Pimecrolimus, Prasugrel, Pregabalin; Reolysin, Rimonabant, Rivaroxaban, Rosuvastatin calcium; Satraplatin, SCH-697243,Selenite sodium, Silodosin, Sorafenib, Sunitinib malate; Talarozole, Taxus, Temsirolimus, Tocilizumab, Tolevamer potassium sodium, Tremelimumab, TTP-889; Uracil; V-260, Valsartan/amlodipine besylate, Vardenafil hydrochloride hydrate, Varenicline tartrate, Varespladib, Vitespen, Voclosporin, VX-001; Xience V; Zotarolimus-eluting stent.

Gene_expression (vaccine) of Fibroblast Growth Factor 1 in Fibroblast associated with pregabalin, influenza in birds, abatacept, hepatitis b virus infection, adalimumab and duloxetine
2) Confidence 0.42 Published 2008 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 18806898 Disease Relevance 0.20 Pain Relevance 0.25
Quantitative analysis showed after endothelial induction, ICAM1, CD31, VCAM1, and vWF were significantly upregulated, while FGF1, Flt1, KDR and VEGFA were expressed in undifferentiated cells and upregulated with endothelial differentiation of hESCs (Figure 4B), which were also consistent with the microarray data.
Gene_expression (expressed) of FGF1
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
Inflammation also may upregulate the expression of angiogenic growth factors such as VEGF and FGF-1 by resident cells such as fibroblasts [6,7].


Gene_expression (expression) of FGF-1 in fibroblasts associated with inflammation
4) Confidence 0.15 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128891 Disease Relevance 1.27 Pain Relevance 0.31

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