INT94835

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 11.57
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (NUDT6) nucleus (NUDT6) cellular_component (NUDT6)
biological_process (NUDT6) cytoplasm (NUDT6)
Anatomy Link Frequency
fibroblasts 4
macrophage 1
esophagus 1
pericardial fluid 1
platelet 1
NUDT6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 106 100.00 Very High Very High Very High
cytokine 61 100.00 Very High Very High Very High
chemokine 12 100.00 Very High Very High Very High
fibrosis 65 99.10 Very High Very High Very High
ischemia 10 98.68 Very High Very High Very High
psoriasis 1 93.60 High High
Inflammatory response 5 81.36 Quite High
Angina 5 66.16 Quite High
imagery 50 5.00 Very Low Very Low Very Low
bDMF 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 108 100.00 Very High Very High Very High
Cancer 32 100.00 Very High Very High Very High
Necrosis 21 100.00 Very High Very High Very High
Eosinophilic Esophagitis 318 99.84 Very High Very High Very High
Choroideremia 830 99.80 Very High Very High Very High
Hypoxia 5 99.14 Very High Very High Very High
Fibrosis 60 99.10 Very High Very High Very High
Coronary Artery Disease 24 98.68 Very High Very High Very High
Injury 22 96.20 Very High Very High Very High
Disease 117 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result indicates that the release of acidic FGF from the myocardial tissue into pericardial fluid is closely related to severe myocardial ischemia.
Localization (release) of acidic FGF in pericardial fluid associated with coronary artery disease and ischemia
1) Confidence 0.52 Published 2000 Journal Heart Vessels Section Abstract Doc Link 11289498 Disease Relevance 0.46 Pain Relevance 0.26
The release of FGF by a wide variety of cells, especially in conditions of cellular damage, may explain the high levels of systemic FGF in EoE subjects.
Localization (release) of FGF associated with eosinophilic esophagitis
2) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.35 Pain Relevance 0.20
The receptors for FGFs (FGFR) are tyrosine kinase receptors that are specific for particular FGF subsets and can be found in a variety of tissues, including epithelial and mesenchymal tissue [20]. bFGF increases the half-life of cells and could possibly increase the overall lifetime of the eosinophil in the esophagus [17].
Localization (subsets) of FGF in esophagus
3) Confidence 0.13 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.85 Pain Relevance 0
The release of FGF by a wide variety of cells, especially in conditions of cellular damage, may explain the high levels of systemic FGF in EoE subjects.
Localization (release) of FGF associated with eosinophilic esophagitis
4) Confidence 0.11 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.40 Pain Relevance 0.21
BMMC and MSC have been extensively studied and proved to produce and secrete a broad variety of cytokines, chemokines, and growth factors, between them VEGF, FGF, HGF, IGF, adrenomedullin, thymosin ?
Localization (secrete) of FGF in HGF associated with chemokine and cytokine
5) Confidence 0.11 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2975079 Disease Relevance 0.08 Pain Relevance 0.10
While the mechanism underlying chronic fibrosis is not fully known, vascular damage and the release of inflammatory cytokines and other factors such as platelet derived growth factor (PDGF), endothelial growth factor (EGF) and fibroblast growth factor (FGF) stimulate fibroblast activation which seems to initiate a pro-fibrotic cascade of events [5-10].
Localization (release) of FGF in platelet associated with fibrosis, inflammation and cytokine
6) Confidence 0.05 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1891306 Disease Relevance 1.66 Pain Relevance 0.50
Angiogenesis is stimulated when hypoxic, diseased, or injured tissues produce and release angiogenic promoters such as vascular endothelial growth factor (VEGF) or fibroblast growth factor (FGF)-1.
Localization (release) of FGF in fibroblast associated with hypoxia
7) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128891 Disease Relevance 1.57 Pain Relevance 0.48
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Localization (several) of FGF
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Localization (morphogens) of FGF
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
Actual levels of secretion of MCP-1, TNF-alpha and FGF for all the controls and CHM samples are presented in Fig. 7B, C and D.
Localization (secretion) of FGF associated with choroideremia
10) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.75 Pain Relevance 0.07
In contrast, fibroblasts from CHM patients, when compared to normal controls, secreted significantly lower levels of MCP-1, PEDF, TNF-alpha, FGF and IL-8.
Localization (secreted) of FGF in fibroblasts associated with choroideremia
11) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.73 Pain Relevance 0
CHM fibroblasts secreted significantly lower levels of macrophage chemoattractant protein (MCP-1), pigment epithelial derived factor (PEDF), tumor necrosis factor (TNF) alpha, fibroblast growth factor (FGF) beta and interleukin (IL)-8 into the media.
Localization (secreted) of FGF in macrophage associated with necrosis, cancer and choroideremia
12) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 1.00 Pain Relevance 0
Finally, CHM fibroblasts secreted significantly lower levels of cytokine/growth factors such as macrophage chemoattractant protein-1 (MCP-1), pigment epithelial derived factor (PEDF), tumor necrosis factor (TNF) alpha, fibroblast growth factor (FGF) beta and interleukin (lL)-8.


Localization (secreted) of FGF in fibroblast associated with necrosis, cancer, choroideremia and cytokine
13) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2793004 Disease Relevance 1.00 Pain Relevance 0.09
Primary fibroblasts from CHM patients released 3.2 fold less IL8, 4 fold less MCP1, 2.8 fold less TNF-alpha, 2.33 fold less FGF and 1.6 fold less of PEDF.
Localization (released) of FGF in fibroblasts associated with choroideremia
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.70 Pain Relevance 0.08

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