INT94853

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Context Info
Confidence 0.06
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.57
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TGFB1, COL7A1) aging (TGFB1) enzyme binding (TGFB1)
embryo development (TGFB1) cytoplasm (TGFB1) extracellular space (TGFB1)
TGFB1 (Homo sapiens)
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 95.64 Very High Very High Very High
Neuropeptide 3 83.12 Quite High
melanocortin 1 receptor 1 81.20 Quite High
fibrosis 3 70.88 Quite High
Chronic pancreatitis 1 62.32 Quite High
Inflammation 2 30.88 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain management 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wound Healing 7 82.40 Quite High
Fibrosis 4 79.36 Quite High
Toxicity 3 72.48 Quite High
Injury 39 65.68 Quite High
Pancreatitis 1 62.32 Quite High
Keloid Scars 1 38.88 Quite Low
INFLAMMATION 2 30.88 Quite Low
Necrosis 1 29.04 Quite Low
Infection 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FOY-007 attenuated the collagen synthesis and PIP production stimulated by TGF-beta1 dose dependently, but FOY-305 inhibited only PIP production.
TGF-beta1 Positive_regulation (stimulated) of Gene_expression (synthesis) of collagen
1) Confidence 0.06 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.13 Pain Relevance 0.14
Transforming growth factor beta, a known potent inducer of collagen synthesis, was used as a positive control.
Transforming growth factor beta Positive_regulation (inducer) of Gene_expression (synthesis) of collagen
2) Confidence 0.05 Published 2010 Journal Eplasty Section Body Doc Link PMC2941189 Disease Relevance 0.36 Pain Relevance 0.03
Alpha-MSH did not interfere with TGF-beta1 signaling, because TGF-beta1-induced expression of collagen mRNA was not affected, implying a posttranscriptional mechanism.
TGF-beta1-induced Positive_regulation (induced) of Gene_expression (expression) of collagen
3) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645373 Disease Relevance 0.08 Pain Relevance 0.21

General Comments

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