INT94860

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 3.20
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
basilar artery 5
DRG 2
trigeminal ganglion 1
middle cerebral artery 1
dura mater 1
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 1 99.84 Very High Very High Very High
qutenza 2 99.56 Very High Very High Very High
dorsal root ganglion 3 99.04 Very High Very High Very High
Migraine 16 96.52 Very High Very High Very High
trigeminal ganglion 16 96.44 Very High Very High Very High
headache 8 95.56 Very High Very High Very High
Pain 8 86.16 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 99.04 Very High Very High Very High
Headache 16 96.52 Very High Very High Very High
Pain 8 86.16 High High
Migraine Disorders 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to describe the expression of phosphodiesterase 3 (PDE3) and 5 (PDE5) and cyclic nucleotide-gated ion channels (CNG) in cerebral arteries, meninges, and the trigeminal ganglion. mRNA for PDE and CNG was determined in the rat middle cerebral artery, basilar artery, trigeminal ganglion, and dura mater using real-time PCR.
Negative_regulation (describe) of Gene_expression (expression) of PDE5 in basilar artery associated with ganglion cysts and trigeminal ganglion
1) Confidence 0.33 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.71 Pain Relevance 0.59
The aim of the present study was to describe the expression of phosphodiesterase 3 (PDE3) and 5 (PDE5) and cyclic nucleotide-gated ion channels (CNG) in cerebral arteries, meninges, and the trigeminal ganglion. mRNA for PDE and CNG was determined in the rat middle cerebral artery, basilar artery, trigeminal ganglion, and dura mater using real-time PCR.
Negative_regulation (describe) of in trigeminal ganglion Gene_expression (expression) of PDE5 in basilar artery associated with ganglion cysts and trigeminal ganglion
2) Confidence 0.11 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.71 Pain Relevance 0.59
The aim of the present study was to describe the expression of phosphodiesterase 3 (PDE3) and 5 (PDE5) and cyclic nucleotide-gated ion channels (CNG) in cerebral arteries, meninges, and the trigeminal ganglion. mRNA for PDE and CNG was determined in the rat middle cerebral artery, basilar artery, trigeminal ganglion, and dura mater using real-time PCR.
Negative_regulation (describe) of in middle cerebral artery Gene_expression (expression) of PDE5 in basilar artery associated with ganglion cysts and trigeminal ganglion
3) Confidence 0.11 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.71 Pain Relevance 0.59
The aim of the present study was to describe the expression of phosphodiesterase 3 (PDE3) and 5 (PDE5) and cyclic nucleotide-gated ion channels (CNG) in cerebral arteries, meninges, and the trigeminal ganglion. mRNA for PDE and CNG was determined in the rat middle cerebral artery, basilar artery, trigeminal ganglion, and dura mater using real-time PCR.
Negative_regulation (describe) of in dura mater Gene_expression (expression) of PDE5 in basilar artery associated with ganglion cysts and trigeminal ganglion
4) Confidence 0.11 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.71 Pain Relevance 0.59
In both dissociated dorsal root ganglion (DRG) cultures and in acutely isolated, but intact, DRG, treatment with capsaicin or bradykinin caused cGMP synthesis, which could be blocked by NOS inhibitors.
Negative_regulation (blocked) of Gene_expression (synthesis) of cGMP in DRG associated with ganglion cysts, dorsal root ganglion, qutenza and bradykinin
5) Confidence 0.04 Published 2001 Journal Nitric Oxide Section Abstract Doc Link 11292360 Disease Relevance 0.36 Pain Relevance 0.30

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