INT9489

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Context Info
Confidence 0.66
First Reported 1987
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 112
Total Number 121
Disease Relevance 55.38
Pain Relevance 66.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
lymphocytes 7
tear 6
immune cells 4
neural 3
teeth 3
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 1526 100.00 Very High Very High Very High
Inflammation 904 100.00 Very High Very High Very High
Neurotransmitter 387 100.00 Very High Very High Very High
Neuropeptide 335 100.00 Very High Very High Very High
calcitonin gene related peptide 208 100.00 Very High Very High Very High
Calcitonin gene-related peptide 157 100.00 Very High Very High Very High
agonist 76 100.00 Very High Very High Very High
Enkephalin 54 100.00 Very High Very High Very High
analgesia 13 100.00 Very High Very High Very High
visual analogue scale 12 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1022 100.00 Very High Very High Very High
Sacroiliitis 40 100.00 Very High Very High Very High
Uveitis 9 100.00 Very High Very High Very High
Acid Reflux 39 99.92 Very High Very High Very High
Seronegative Spondarthritis 474 99.84 Very High Very High Very High
Endometriosis 448 99.84 Very High Very High Very High
Rheumatoid Arthritis 442 99.80 Very High Very High Very High
Generalized Anxiety Disorder 209 99.80 Very High Very High Very High
Pain 142 99.74 Very High Very High Very High
Pruritus 219 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients in the SpA groups had higher percentages in onset <40 years, insidious onset, morning stiffness, and affected for >3 months compared with those in other LBP groups.
Gene_expression (groups) of SpA
1) Confidence 0.66 Published 2009 Journal Scand. J. Rheumatol. Section Body Doc Link 19922021 Disease Relevance 0.06 Pain Relevance 0
Among the alpha, beta, and gamma transcripts of the SP gene, only the beta and gamma transcripts are detectable in these cells.
Gene_expression (detectable) of SP associated with substance p
2) Confidence 0.60 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9655475 Disease Relevance 0 Pain Relevance 0.36
CONCLUSIONS: The survey questionnaire for SpA in this study is useful for axial SpA screening in China.
Gene_expression (screening) of SpA
3) Confidence 0.58 Published 2009 Journal Scand. J. Rheumatol. Section Body Doc Link 19922021 Disease Relevance 0 Pain Relevance 0
RESULTS: The 5 subsets of SpA share many clinical, immunohistochemical, and genetic features, including the common presence of human leukocyte antigen-B27 and the absence of rheumatoid factor.
Gene_expression (presence) of SpA in leukocyte
4) Confidence 0.55 Published 2008 Journal Semin. Arthritis Rheum. Section Body Doc Link 18166219 Disease Relevance 0.09 Pain Relevance 0
Therefore, we created an ambitious project that involves both general practitioners and rheumatologists called ESPERANZA, with the purpose of early detection of SpA.
Gene_expression (detection) of SpA
5) Confidence 0.54 Published 2011 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2999954 Disease Relevance 0.35 Pain Relevance 0.21
We cannot entirely rule out the alternative possibility that abnormally lengthened SP duration observed in the patient group was related to the trend towards a higher resting MT, but this explanation seems unlikely.
Gene_expression (duration) of SP
6) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.17 Pain Relevance 0.38
Results revealed no significant difference between groups in the three measures (MT, paired TMS, and SP duration).
Gene_expression (duration) of SP associated with transcranial magnetic stimulation
7) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0 Pain Relevance 0.12
We found that, whereas in both groups SP duration lengthened with increasing stimulus intensity, participants with agenesis of the CC showed significantly longer SPs.
Gene_expression (duration) of SP
8) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.08 Pain Relevance 0.04
L-DOPA and dopamine agonists also appear to lengthen SP duration [43].
Gene_expression (duration) of SP associated with dopamine and agonist
9) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.16 Pain Relevance 0.47
Lastly, subjects participated in the SP experiment.
Gene_expression (experiment) of SP
10) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0 Pain Relevance 0.15
As it is known that agenesis of the corpus callosum may be associated with a variety of central nervous system abnormalities, it is possible that these abnormalities are also involved in SP prolongation.
Gene_expression (prolongation) of SP in central nervous system associated with congenital anomalies, nervous system malformation and central nervous system
11) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.26 Pain Relevance 0.29
It is important to mention that SP duration may depend on a variety of factors in addition to potentially being a measure of GABA-b mediated cortical inhibition.
Gene_expression (duration) of SP associated with gaba
12) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.17 Pain Relevance 0.44
Our data support this conclusion, as only SP duration was affected in our patient population, presumably through GABA-b receptors, whereas short ICI was normal.
Gene_expression (duration) of SP associated with gaba
13) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.13 Pain Relevance 0.46
The patient group showed a greater SP duration than the control group for both hemispheres (mean duration (s.e.m)of the left hemisphere: patient = 153.0 ± 17.0 ms; control = 120.6 ± 2.3 ms; mean duration (s.e.m) of the right hemisphere: patient = 154.5 ± 17.0 ms; control = 129.3 ± 3.2 ms; ANOVA, F = 6.10; P = 0.02; Figure 3).
Gene_expression (duration) of SP
14) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0 Pain Relevance 0
For instance, SP has been reported to be prolonged in patients with lesions of the premotor cortex, lesions of the parietal and temporal lobe, and lesions of the internal capsule and thalamus [40].
Gene_expression (prolonged) of SP in cortex associated with thalamus
15) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.24 Pain Relevance 0.09
However, as shown in Figure 5, higher MTs observed in our patients do not seem to be related to SP duration.
Gene_expression (duration) of SP
16) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.09 Pain Relevance 0.31
Only patient M.G. did not complete the SP experiment (at the intensity of 130% of the left hemisphere) because he felt tired.
Gene_expression (experiment) of SP
17) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0 Pain Relevance 0.09
An alternative possibility is that abnormally lengthened SP duration observed in the patient group was related to the influence of motor set, motor instruction, or motor attention [28,45,46].
Gene_expression (duration) of SP
18) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.09 Pain Relevance 0.09
The antagonism of pretectal stimulation produced analgesia (PSPA) by naloxone and atropine, raises the possibility of involvement of both endogenous opioids and cholinergic mechanisms in pretectal analgesia.
Gene_expression (produced) of PSPA associated with endogenous opioid, narcan and analgesia
19) Confidence 0.48 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421114 Disease Relevance 0 Pain Relevance 0.75
The demonstration that human lymphocytes express SP and its receptor support the notion that SP is biologically involved in regulating the functions of these cells in an autocrine fashion.
Gene_expression (express) of SP in lymphocytes associated with substance p
20) Confidence 0.47 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9655475 Disease Relevance 0 Pain Relevance 0.48

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