INT94891

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
cleavage 1
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain management 1 97.88 Very High Very High Very High
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 1 97.44 Very High Very High Very High
Muscle Disease 1 96.92 Very High Very High Very High
Immunization 5 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Gastroenteritis 3 5.00 Very Low Very Low Very Low
Poisoning 3 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Bacillus Anthracis Infection 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BoNT/A is a Zn(2+) endopeptidase which selectively cleaves SNAP-25 (synaptosomal-associated protein of 25 kDa), a critical component of the exocytotic machinery.
Protein_catabolism (cleaves) of SNAP-25
1) Confidence 0.55 Published 2001 Journal Biochemistry Section Abstract Doc Link 11294637 Disease Relevance 0.19 Pain Relevance 0.10
Six of 14 anti-A clones exhibited inhibition of SNAP-25 cleavage in the neuro-2A assay indicating some sdAb had toxin neutralizing capabilities.
Protein_catabolism (cleavage) of SNAP-25 in cleavage
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2809108 Disease Relevance 0 Pain Relevance 0

General Comments

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