INT94896

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.04
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (TEP1) RNA binding (TEP1) nucleus (TEP1)
cytoplasm (TEP1)
Anatomy Link Frequency
telomere 3
hepatocytes 1
MKN-45 1
TEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 4 100.00 Very High Very High Very High
cINOD 9 96.34 Very High Very High Very High
Pain 5 77.92 Quite High
Angina 2 67.44 Quite High
Inflammation 25 66.00 Quite High
Chronic pancreatitis 1 51.20 Quite High
Inflammatory response 1 44.64 Quite Low
Kinase C 282 25.00 Low Low
COX2 1 25.00 Low Low
agonist 33 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 311 99.76 Very High Very High Very High
Apoptosis 29 99.46 Very High Very High Very High
Stomach Cancer 5 98.60 Very High Very High Very High
Endometriosis (extended) 1 97.64 Very High Very High Very High
Pancreatic Cancer 7 96.52 Very High Very High Very High
Aging 41 96.16 Very High Very High Very High
INFLAMMATION 34 93.60 High High
Sprains And Strains 6 93.04 High High
Diabetes Mellitus 86 92.24 High High
Aggression 1 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with this observation, recent data indicate that telomerase is actively regulated throughout the cell cycle in murine hepatocytes [17].
Regulation (regulated) of telomerase in hepatocytes
1) Confidence 0.39 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.35 Pain Relevance 0
Also, NSAIDs at 25 microM (sulindac sulfone) decreased growth and telomerase activity in MCG-101 cells, without any effects on PGE2 production, while ibuprofen reduced PGE2 production but had no effect on growth or telomerase activity.
Neg (no) Regulation (effect) of telomerase associated with cinod
2) Confidence 0.27 Published 2001 Journal Int. J. Oncol. Section Abstract Doc Link 11295037 Disease Relevance 1.10 Pain Relevance 0.17
More important, diagnositic values of telomerase activity are highly focused because of the lack of other specific genetic markers for pancreatic cancer.
Regulation (values) of telomerase associated with pancreatic cancer
3) Confidence 0.25 Published 2005 Journal Methods Mol. Med. Section Abstract Doc Link 15542908 Disease Relevance 0.90 Pain Relevance 0.05
Unfortunately, there are significant differences between mice and humans regarding telomere biology that are possible concerns in the use of mouse models to investigate telomere maintenance and telomerase regulation.
Spec (investigate) Regulation (regulation) of telomerase in telomere
4) Confidence 0.17 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.34 Pain Relevance 0
Because of these similarities, pigs have been utilized as model system to investigate telomerase regulation and telomere dynamics in mammalians [23].
Spec (investigate) Regulation (regulation) of telomerase in telomere
5) Confidence 0.17 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.30 Pain Relevance 0
We aimed to study the effects of the selective COX-2 inhibitor, nimesulide, on cell viability and telomerase and Akt/PKB activity in the human gastric cancer cell line MKN-45 and to explore the molecular mechanism for the antitumor activity of the selective COX-2 inhibitor.
Regulation (effects) of telomerase in MKN-45 associated with cox-2 inhibitor and stomach cancer
6) Confidence 0.15 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15309882 Disease Relevance 0.35 Pain Relevance 0.19
The mechanisms involved in the regulation of telomerase activity are of special interest since the modulation of telomerase activity can be used to alter cellular life span and thus, can be exploited in anti-cancer and anti-ageing therapies.
Regulation (regulation) of telomerase associated with aging and cancer
7) Confidence 0.08 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.28 Pain Relevance 0
Bcl-2, the oncoprotein involved in the inhibition of cellular apoptosis has also been reported to modulate telomerase activity [10,11].
Regulation (modulate) of telomerase associated with apoptosis
8) Confidence 0.06 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.54 Pain Relevance 0
Available evidence suggests that the regulation of telomerase activity primarily depends on the transcriptional control of the human telomerase reverse transcriptase (hTERT) gene.
Regulation (regulation) of telomerase
9) Confidence 0.03 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.08 Pain Relevance 0
Although various steps at post-transcriptional and post-translational levels have been found to modulate telomerase activity, substantial experimental data have established that the transcriptional control of hTERT gene is the major contributor to the regulation of telomerase activity in most cell types [7].
Regulation (regulation) of telomerase
10) Confidence 0.03 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.31 Pain Relevance 0
Although various steps at post-transcriptional and post-translational levels have been found to modulate telomerase activity, substantial experimental data have established that the transcriptional control of hTERT gene is the major contributor to the regulation of telomerase activity in most cell types [7].
Regulation (modulate) of telomerase
11) Confidence 0.03 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.25 Pain Relevance 0
The mechanisms involved in the regulation of telomerase activity are of special interest since the modulation of telomerase activity can be used to alter cellular life span and thus, can be exploited in anti-cancer and anti-ageing therapies.
Regulation (modulation) of telomerase associated with aging and cancer
12) Confidence 0.03 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.28 Pain Relevance 0
These results demonstrate the immunological feasibility of targeting telomerase as a tumor rejection antigen and provide rationale for telomerase vaccine trials in healthier cancer patients [5].
Regulation (targeting) of telomerase associated with cancer
13) Confidence 0.01 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.31 Pain Relevance 0.08
An oestrogen-responsive element exists in telomerase, the enzyme that replaces telomeric loss in progenitor cells [44]; thus hormonal changes may influence telomerase to maintain telomere length in the progenitor cells after menopause.
Spec (may) Regulation (influence) of telomerase in telomere associated with endometriosis (extended)
14) Confidence 0.00 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 1.65 Pain Relevance 0.20

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