INT949

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.06
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRH) extracellular region (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
Anatomy Link Frequency
plasma 1
hypothalamus 1
TRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 5 100.00 Very High Very High Very High
anesthesia 3 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
anticonvulsant 6 99.98 Very High Very High Very High
substance P 2 99.92 Very High Very High Very High
Opioid 4 99.76 Very High Very High Very High
antagonist 4 99.56 Very High Very High Very High
Dopamine 1 99.24 Very High Very High Very High
tolerance 1 99.18 Very High Very High Very High
nociceptor 1 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 1 99.18 Very High Very High Very High
Obesity 6 99.04 Very High Very High Very High
Amnesia 1 96.56 Very High Very High Very High
Pituitary Cancer 3 93.16 High High
Epilepsy 5 92.56 High High
Hypocalcemia 5 90.24 High High
Congenital Anomalies 1 90.04 High High
Headache 4 88.88 High High
Attention Deficit Hyperactivity Disorder 2 85.28 High High
Granular Cell Tumor 5 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Failure of thyrotropin releasing hormone to reverse fentanyl-flunitrazepam anesthesia in man.
Negative_regulation (Failure) of thyrotropin releasing hormone associated with anesthesia
1) Confidence 0.43 Published 1986 Journal Acta Anaesthesiol Belg Section Title Doc Link 3098036 Disease Relevance 0.16 Pain Relevance 0.50
The NMDA-receptor antagonist dizocilpine (MK-801) suppresses the memory facilitatory action of thyrotropin-releasing hormone.
Negative_regulation (suppresses) of thyrotropin-releasing hormone associated with nociceptor and antagonist
2) Confidence 0.43 Published 1992 Journal Neuropeptides Section Title Doc Link 1454156 Disease Relevance 0.10 Pain Relevance 0.27
TRH is widely distributed not only in hypothalamus, but also in extrahypothalamic parts of CNS as well as in many peripheral tissues and organs.
Negative_regulation (distributed) of TRH in hypothalamus
3) Confidence 0.43 Published 1991 Journal Srp Arh Celok Lek Section Abstract Doc Link 1806996 Disease Relevance 0 Pain Relevance 0.17
The effects of motilin, neurotensin, and thyrotropin-releasing hormone were greatly reduced or abolished by perfusion of the preparation with tetrodotoxin.
Negative_regulation (reduced) of thyrotropin-releasing hormone associated with tetrodotoxin
4) Confidence 0.42 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 115560 Disease Relevance 0 Pain Relevance 0.54
The anticonvulsant potencies of CCK, TRH, and opioid peptides have been defined more clearly with these methods.
Negative_regulation (potencies) of TRH associated with anticonvulsant, opioid and cholecystokinin
5) Confidence 0.41 Published 1986 Journal Adv Neurol Section Abstract Doc Link 2871723 Disease Relevance 0.25 Pain Relevance 0.53
The patient's basal GH levels were mildly elevated at 4.8 microg/L, were not suppressed in response to an oral glucose tolerance test, and increased paradoxically after administration of thyrotropin-releasing hormone.
Negative_regulation (administration) of thyrotropin-releasing hormone associated with tolerance and impaired glucose tolerance
6) Confidence 0.41 Published 2000 Journal J. Neurosurg. Section Abstract Doc Link 10883914 Disease Relevance 1.07 Pain Relevance 0.14
A second injection of either TRH or hpGRF failed to increase the GH concentration in immature chicks when administered 15, 30, or 60 min after the first injection.
Negative_regulation (injection) of TRH
7) Confidence 0.41 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926599 Disease Relevance 0 Pain Relevance 0
An abnormal increase in plasma GH occurred in 5 out of the 10 patients who received TRH, while plasma GH did not show significant variations during testing in the subjects who received saline.
Negative_regulation (received) of TRH in plasma
8) Confidence 0.38 Published 1991 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 1907565 Disease Relevance 0.24 Pain Relevance 0.51
She responded normally to infusions of GHRH (GH rose to 22 ng/ml (22 micrograms/L) at 75 minutes) and TRH (TSH rose to 37 mu u/ml, 37 mIU/L).
Negative_regulation (infusions) of TRH
9) Confidence 0.35 Published 1994 Journal Am. J. Med. Genet. Section Abstract Doc Link 7810565 Disease Relevance 0.68 Pain Relevance 0.10
All patients received 200 micrograms TRH and 0.5 g/kg b.w. arginine together with 2 mg of naloxone or placebo i.v. in a randomized sequence.
Negative_regulation (received) of TRH associated with narcan
10) Confidence 0.28 Published 1987 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3035002 Disease Relevance 0.40 Pain Relevance 0.47
However, stimulators and inhibitors of PRL secretion such as TRH, bromocriptine or dopamine have no effect on dPRL release.
Negative_regulation (inhibitors) of TRH associated with dopamine
11) Confidence 0.28 Published 1992 Journal Endocrinology Section Abstract Doc Link 1597150 Disease Relevance 0 Pain Relevance 0.16
METHODS: Eighteen patients with CM-MOH, diagnosed according to the ICHD-II criteria, and 18 healthy controls received an intravenous administration of GHRH, hCRH, and TRH.
Negative_regulation (administration) of TRH
12) Confidence 0.05 Published 2006 Journal Headache Section Body Doc Link 16643554 Disease Relevance 0.16 Pain Relevance 0

General Comments

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