INT9490

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Context Info
Confidence 0.56
First Reported 1983
Last Reported 2009
Negated 5
Speculated 5
Reported most in Abstract
Documents 44
Total Number 51
Disease Relevance 6.69
Pain Relevance 19.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
brain 6
central nervous system 3
uterine 2
hypothalamus 2
upper 2
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 36 100.00 Very High Very High Very High
qutenza 32 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
Intracerebroventricular 3 100.00 Very High Very High Very High
Antinociceptive 3 99.98 Very High Very High Very High
substance P 48 99.92 Very High Very High Very High
narcan 32 99.92 Very High Very High Very High
Analgesic 9 99.92 Very High Very High Very High
Enkephalin 117 99.90 Very High Very High Very High
Pain 9 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 21 100.00 Very High Very High Very High
Depression 2 99.98 Very High Very High Very High
Hypoxia 6 99.84 Very High Very High Very High
Acute Renal Failure 12 99.60 Very High Very High Very High
Nociception 3 99.08 Very High Very High Very High
Opiate Addiction 5 99.04 Very High Very High Very High
Cancer 2 99.00 Very High Very High Very High
Adenoma 3 98.80 Very High Very High Very High
Pheochromocytoma 9 97.62 Very High Very High Very High
Hypersensitivity 4 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stress influences brain enkephalinase, oxytocinase and angiotensinase activities: a new hypothesis.
Regulation (influences) of enkephalinase in brain associated with stress
1) Confidence 0.56 Published 2009 Journal Neuropsychobiology Section Title Doc Link 19468242 Disease Relevance 0.44 Pain Relevance 0.30
These results show that acute immobilization stress affects differentially enkephalinase and oxytocinase activities depending on the fraction and brain region analyzed.
Regulation (affects) of enkephalinase in brain associated with stress
2) Confidence 0.56 Published 2009 Journal Neuropsychobiology Section Abstract Doc Link 19468242 Disease Relevance 0.51 Pain Relevance 0.55
The effect of acute immobilization stress on enkephalinase and oxytocinase activities was determined in the soluble and membrane fractions of the medial prefrontal cortex, hippocampus and amygdala using alanyl- and leucyl-beta-naphthylamide as substrates, the latter in the presence and absence of 20 mM L-methionine.
Regulation (effect) of enkephalinase in prefrontal associated with stress, hippocampus and amygdala
3) Confidence 0.56 Published 2009 Journal Neuropsychobiology Section Abstract Doc Link 19468242 Disease Relevance 0.36 Pain Relevance 0.25
Down regulation of kidney neutral endopeptidase mRNA, protein and activity during acute renal failure: possible mechanism for ischemia-induced acute renal failure in rats?
Spec (possible) Regulation (regulation) of neutral endopeptidase in kidney associated with acute renal failure and ischemia
4) Confidence 0.54 Published 1999 Journal Mol. Cell. Biochem. Section Title Doc Link 10485324 Disease Relevance 0.64 Pain Relevance 0.26
These data, along with the reported increase in the tissue level of ET in kidney cortex, and the beneficial effect of ET antibody as well as ET receptor antagonist in ARF, suggest that down regulation of NEP, one of the mechanisms leading to increased tissue level of ET, may be a contributing factor to ARF.
Regulation (regulation) of NEP in kidney cortex associated with acute renal failure and antagonist
5) Confidence 0.54 Published 1999 Journal Mol. Cell. Biochem. Section Abstract Doc Link 10485324 Disease Relevance 0.64 Pain Relevance 0.23
Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression.
Regulation (modulation) of neprilysin associated with limbic system
6) Confidence 0.52 Published 2007 Journal J. Mol. Neurosci. Section Title Doc Link 17952634 Disease Relevance 0.06 Pain Relevance 0.29
The effects of two enkephalinase inhibitors, SCH 34826 and phospho-leu-phe, on male rat sexual behavior and conditioned place preference were evaluated.
Regulation (effects) of enkephalinase
7) Confidence 0.45 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8029244 Disease Relevance 0 Pain Relevance 0
Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue, [D-Ala2-Met5]-enkephalinamide, on uterine motility in periparturient rats in vivo and in vitro.
Regulation (effects) of enkephalinase in uterine associated with narcan and enkephalin
8) Confidence 0.45 Published 1995 Journal J. Reprod. Fertil. Section Title Doc Link 7473405 Disease Relevance 0.09 Pain Relevance 0.44
The effects of two enkephalinase inhibitors, acetorphan and thiorphan, and the enkephalin analogue [D-Ala2-Met5]-enkephalinamide (DAMEA), on spontaneous uterine contractions were studied at day 21 of pregnancy in rats following treatment in vivo or in vitro.
Regulation (effects) of enkephalinase in uterine associated with dismenorea and enkephalin
9) Confidence 0.45 Published 1995 Journal J. Reprod. Fertil. Section Abstract Doc Link 7473405 Disease Relevance 0.10 Pain Relevance 0.27
The enkephalinase inhibitors thiorphan and SCH 32615, at a concentration of 1-500 microM, failed to significantly affect CA1 and dentate FPs.
Neg (failed) Regulation (affect) of enkephalinase
10) Confidence 0.45 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1924493 Disease Relevance 0 Pain Relevance 0.16
Effects of the enkephalinase inhibitor SCH 34826 on the sleep-waking cycle and EEG activity in the rat.
Regulation (Effects) of enkephalinase
11) Confidence 0.45 Published 1990 Journal Neuropharmacology Section Title Doc Link 2325830 Disease Relevance 0.06 Pain Relevance 0.37
In this study we examined the effects of the enkephalinase inhibitor, thiorphan, on the naloxone-precipitated withdrawal syndrome in chronic morphine dependent rats.
Spec (examined) Regulation (effects) of enkephalinase associated with narcan, withdrawal and morphine
12) Confidence 0.45 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 3549428 Disease Relevance 0.38 Pain Relevance 0.65
On the other hand, the globus pallidus, the substantia nigra, and the central gray matter, which show a high or a moderate amount of neprilysin, did not contain any neprilysin mRNA.
Neg (not) Regulation (contain) of neprilysin mRNA in globus pallidus associated with substantia nigra
13) Confidence 0.45 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8474144 Disease Relevance 0 Pain Relevance 0.18
We have developed a novel fluorescent histochemical method to localize the enzyme neutral endopeptidase-24.11 (NEP, E.C. 3.4.24.11, enkephalinase) in the rat brain in order to directly compare the relative distributions of the enzyme and its putative peptide substrate, the enkephalins.
Regulation (localize) of NEP in brain associated with enkephalin
14) Confidence 0.45 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2593007 Disease Relevance 0 Pain Relevance 0.17
The effects of orally active enkephalinase inhibitors on morphine withdrawal syndrome.
Regulation (effects) of enkephalinase associated with analgesic, withdrawal and morphine
15) Confidence 0.45 Published 1992 Journal Neuroreport Section Title Doc Link 1421123 Disease Relevance 0.27 Pain Relevance 0.74
The presence of opioid receptors and enkephalin-releasing neurons in the spinal dorsal horn prompted us to examine whether an enkephalinase inhibitor, SCH32615, given intrathecally would alter the response of the rat on several nociceptive endpoints: 49 degrees C hot plate (HP), 52 degrees C HP; tail flick (TF) and the paw pressure (PP) test.
Regulation (response) of enkephalinase in dorsal horn associated with nociception, spinal dorsal horn, tail-flick, enkephalin and opioid receptor
16) Confidence 0.45 Published 1990 Journal Brain Res. Section Abstract Doc Link 2357551 Disease Relevance 0.10 Pain Relevance 0.46
Depressive effects of morphine and of an enkephalinase inhibitor on responses of ventro-basal thalamic neurones to noxious stimuli.
Regulation (effects) of enkephalinase associated with nociceptor and morphine
17) Confidence 0.44 Published 1983 Journal Life Sci. Section Title Doc Link 6363853 Disease Relevance 0.10 Pain Relevance 0.51
Enkephalinase B is not affected by phosphate or thiorphan.
Neg (not) Regulation (affected) of Enkephalinase
18) Confidence 0.40 Published 1983 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6578795 Disease Relevance 0 Pain Relevance 0.26
The effects of intraperitoneal and intracerebroventricular administration of the inhibitor of endopeptidase EC 24.11 (enkephalinase), thiorphan, and the synthetic enkephalin analogue [D-Ala2-Met5]enkephalinamide (DALA) were investigated in cold-restraint-stressed rats.
Regulation (effects) of endopeptidase EC 24.11 associated with enkephalin and intracerebroventricular
19) Confidence 0.40 Published 1996 Journal Pharmacology Section Abstract Doc Link 8966203 Disease Relevance 0 Pain Relevance 0.36
Effect of recombinant neutral endopeptidase (EC 3.4.24.11) on neuropeptide-mediated nasal fluid secretion and plasma exudation in the rat.
Regulation (Effect) of neutral endopeptidase in plasma associated with qutenza and neuropeptide
20) Confidence 0.39 Published 1998 Journal Am J Rhinol Section Title Doc Link 9578933 Disease Relevance 0 Pain Relevance 0.80

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