INT9491

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 17
Disease Relevance 2.33
Pain Relevance 7.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptpn6) phosphatase activity (Ptpn6) cell proliferation (Ptpn6)
nucleus (Ptpn6) cytoplasm (Ptpn6)
Anatomy Link Frequency
spinal 2
eye 1
blood 1
pituitary 1
Ptpn6 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 15 100.00 Very High Very High Very High
Somatostatin 17 99.98 Very High Very High Very High
antinociception 162 99.96 Very High Very High Very High
Morphine 88 99.32 Very High Very High Very High
analgesia 124 98.96 Very High Very High Very High
ischemia 13 98.48 Very High Very High Very High
Opioid 147 96.64 Very High Very High Very High
narcan 126 95.56 Very High Very High Very High
Central nervous system 37 93.36 High High
addiction 24 90.08 High High
Disease Link Frequency Relevance Heat
Hyperglycemia 2 99.50 Very High Very High Very High
Cv Unclassified Under Development 3 98.48 Very High Very High Very High
Pressure And Volume Under Development 37 97.76 Very High Very High Very High
Diabetes Mellitus 7 92.08 High High
Pain 84 79.92 Quite High
Traumatic Shock 2 75.00 Quite High
Reperfusion Injury 1 75.00 Quite High
Coronary Artery Disease 4 73.36 Quite High
Targeted Disruption 24 69.68 Quite High
Vibrio Infection 6 69.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Met-enkephalin (ME) and beta-endorphin (BE) levels were determined to increase in blood and mid-brain 3 hours later after soft tissue compression of pelvic extremities. 48 hours later after six-hour compression BE and ME level in blood was increased, BE concentration in blood was also increased, and enkephalins' content in brain and blood was decreased as against the control.
Spec (determined) Positive_regulation (increase) of ME in blood associated with enkephalin
1) Confidence 0.51 Published 1992 Journal Biull Eksp Biol Med Section Abstract Doc Link 1421252 Disease Relevance 0.07 Pain Relevance 0.67
Recently, we reported that exogenous administration of Met(5)-enkephalin (ME) for 24 h reduces infarct size after ischemia-reperfusion in rabbits.
Positive_regulation (administration) of ME associated with ischemia and enkephalin
2) Confidence 0.44 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15550529 Disease Relevance 0.52 Pain Relevance 0.65
We found that the size of the CTB-positive area rapidly increased within 5 days after ME and was relatively stable afterwards.
Positive_regulation (increased) of ME
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
Time course of the rearrangement of retinogeniculate projections in response to ME
Positive_regulation (response) of ME
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
ME at P34 did not have an apparent effect upon the size of the CTB-positive area (ME, 13.6±0.5%, n?
Positive_regulation (area) of ME
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
We further quantified VGLUT1 signal intensities within a rectangular area (Figure S4D, green box) and found that VGLUT1 signal intensities did not change in ME-treated animals (Figure S4D), suggesting that corticogeniculate axons are relatively insensitive to ME.
Neg (not) Positive_regulation (change) of ME
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
We tested whether RGCs are still capable of changing their projection patterns in the dLGN in response to ME after eye-specific segregation is mostly complete in mice.
Positive_regulation (response) of ME in eye
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0.12 Pain Relevance 0
GHRH and SRIH accumulate in nerve endings at the ME, and are liberated into portal veins to regulate pituitary GH.
Positive_regulation (accumulate) of ME in pituitary associated with somatostatin
8) Confidence 0.10 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.27
In contrast, when ME was performed at P22, there was only a subtle increase in the CTB-positive area (ME, 15.5±1.2%, n?
Positive_regulation (increase) of ME
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
Thus a lower concentration of ME was also evaluated.
Positive_regulation (concentration) of ME
10) Confidence 0.08 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.69 Pain Relevance 0.07
This effect of ME was markedly potentiated by addition of the mixture of peptidase inhibitors owing to the inhibition of the degradation of ME.
Positive_regulation (potentiated) of ME
11) Confidence 0.07 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.12 Pain Relevance 0.54
Reduction of STZ-induced hyperglycemia by insulin reversed the effectiveness of SC MeNTX in antagonizing morphine analgesia.
Positive_regulation (effectiveness) of MeNTX associated with hyperglycemia, analgesia and morphine
12) Confidence 0.07 Published 1988 Journal Life Sci. Section Abstract Doc Link 2846978 Disease Relevance 0.60 Pain Relevance 0.81
-EP injected into the fourth ventricle could increase immunoreactive ME in the spinal perfusate in urethane-anesthetized rats; furthermore, Bestatin increased the amount of immunoreactive ME released by ?
Positive_regulation (increased) of ME in spinal
13) Confidence 0.06 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.77
These results not only indicated that the inhibition of APN might augment the exogenous ME antinociception but also suggested that Bestatin and its analogs might cause the enhancement of the endogenous ME-mediated antinociception.
Positive_regulation (enhancement) of ME associated with antinociception
14) Confidence 0.06 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.08 Pain Relevance 0.80
It was also proved that ME hydrolyzing enzymes were involved in the degradation of not only ME but also ?
Positive_regulation (enzymes) of ME
15) Confidence 0.06 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.05 Pain Relevance 1.15
-EP injected into the fourth ventricle could increase immunoreactive ME in the spinal perfusate in urethane-anesthetized rats; furthermore, Bestatin increased the amount of immunoreactive ME released by ?
Positive_regulation (increase) of ME in spinal
16) Confidence 0.06 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.77
These results not only indicated that the inhibition of APN might augment the exogenous ME antinociception but also suggested that Bestatin and its analogs might cause the enhancement of the endogenous ME-mediated antinociception.
Spec (might) Positive_regulation (augment) of ME associated with antinociception
17) Confidence 0.06 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.08 Pain Relevance 0.83

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox