INT94924

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.22
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cflar)
Anatomy Link Frequency
NSCs 2
osteoblasts 1
Cflar (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 43 99.80 Very High Very High Very High
Inflammation 18 99.52 Very High Very High Very High
Hippocampus 37 98.20 Very High Very High Very High
antidepressant 62 96.80 Very High Very High Very High
depression 44 84.24 Quite High
Central nervous system 17 83.20 Quite High
Spinal cord 7 83.12 Quite High
withdrawal 7 82.72 Quite High
Serotonin 10 82.00 Quite High
dexamethasone 43 81.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 25 99.52 Very High Very High Very High
Apoptosis 129 99.26 Very High Very High Very High
Death 22 96.96 Very High Very High Very High
Neurodegenerative Disease 107 85.92 High High
Depression 44 84.24 Quite High
Osteoporosis 27 71.76 Quite High
Hyperalgesia 3 68.08 Quite High
Injury 7 65.96 Quite High
Cv Unclassified Under Development 12 60.72 Quite High
Nociception 1 58.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results further showed that fluoxetine protects the lipopolysaccharide-induced apoptosis in NSCs, in part, by activating the expression of c-FLIP.
Gene_expression (expression) of FLIP in NSCs associated with apoptosis and fluoxetine
1) Confidence 0.75 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16545775 Disease Relevance 0.25 Pain Relevance 0.96
The up-regulated expression of Bcl-2, Bcl-xL and the cellular FLICE-inhibitory protein (c-FLIP) in fluoxetine-treated NSCs was detected by real-time RT-PCR.
Gene_expression (expression) of FLIP in NSCs associated with fluoxetine
2) Confidence 0.75 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16545775 Disease Relevance 0.25 Pain Relevance 0.97
The GluR1-flip mRNA was not detected in the samples and the mRNAs for other splice variants did not exhibit significant changes.
Neg (not) Gene_expression (detected) of flip
3) Confidence 0.65 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.89 Pain Relevance 0.69
min prior to mitogen stimulation, suggesting a regulatory role for MEKĀ–ERK in FLIP gene expression in osteoblasts.
Gene_expression (expression) of FLIP gene in osteoblasts
4) Confidence 0.14 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.59 Pain Relevance 0.19
Chiou et al. demonstrated that fluoxetine upregulated the expression of c-FLIP [28].
Gene_expression (expression) of c-FLIP associated with fluoxetine
5) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2885092 Disease Relevance 0.37 Pain Relevance 0.40
This upregulation involved PI3k/AKT pathway, since administration of PI3-K inhibitor LY294002 dose-dependently reduced fluoxetine-mediated activation of c-FLIP promotor and protein expression of c-FLIP [28].
Gene_expression (expression) of c-FLIP associated with fluoxetine
6) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2885092 Disease Relevance 0.44 Pain Relevance 0.38
This upregulation involved PI3k/AKT pathway, since administration of PI3-K inhibitor LY294002 dose-dependently reduced fluoxetine-mediated activation of c-FLIP promotor and protein expression of c-FLIP [28].
Gene_expression (expression) of c-FLIP promotor associated with fluoxetine
7) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2885092 Disease Relevance 0.44 Pain Relevance 0.38

General Comments

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