INT94927

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 3.14
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
hypothalamus 2
cerebral cortex 1
striatum 1
brain 1
hippocampus 1
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 129 100.00 Very High Very High Very High
Glutamate receptor 64 100.00 Very High Very High Very High
depression 207 99.76 Very High Very High Very High
Inflammation 13 99.76 Very High Very High Very High
nMDA receptor 305 99.32 Very High Very High Very High
Dopamine 131 98.96 Very High Very High Very High
Hippocampus 257 98.88 Very High Very High Very High
cerebral cortex 26 98.68 Very High Very High Very High
butorphanol 10 98.64 Very High Very High Very High
Thalamus 8 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 221 99.76 Very High Very High Very High
INFLAMMATION 13 99.76 Very High Very High Very High
Aging 230 94.20 High High
Diabetes Mellitus 89 88.24 High High
Toxicity 3 87.08 High High
Hyperglycemia 2 72.92 Quite High
Cognitive Disorder 65 70.64 Quite High
Ganglion Cysts 7 69.80 Quite High
Hyperalgesia 3 68.08 Quite High
Sprains And Strains 14 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increases in [(3)H]-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor binding and mRNA expression of AMPA-sensitive glutamate receptor A (GluR-A) subunits in rats withdrawn from butorphanol.
Transcription (expression) of GluR-A associated with glutamate receptor and butorphanol
1) Confidence 0.69 Published 2005 Journal J. Toxicol. Environ. Health Part A Section Title Doc Link 16326431 Disease Relevance 0 Pain Relevance 0.67
BDNF ASO and GluR1 ASO are specific for rat BDNF mRNA and GluR1 mRNA respectively [24], [83].
Transcription (mRNA) of GluR1
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.09 Pain Relevance 0.03
These findings suggest that increases in expression of mRNA for the GluR-A receptor and in the binding of AMPA to its receptor may play an important role during withdrawal from butorphanol dependence.
Transcription (expression) of GluR-A associated with addiction, butorphanol and withdrawal
3) Confidence 0.67 Published 2005 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 16326431 Disease Relevance 0 Pain Relevance 0.93
BDNF ASO and GluR1 ASO are specific for rat BDNF mRNA and GluR1 mRNA respectively [24], [83].
Transcription (specific) of GluR1 ASO
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.09 Pain Relevance 0.08
The expressions of phospho-Ser845-GluR1 and c-fos mRNA (in striatum and cerebral cortex) are enhanced by administration of fluoxetine or 2-ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), a 5-HT6 receptor agonist.
Transcription (expressions) of GluR1 in cerebral cortex associated with agonist, cerebral cortex and fluoxetine
5) Confidence 0.52 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.17 Pain Relevance 0.80
The level of expression of each glutamate receptor subunit is determined, at any particular time, by the balance of the rates of gene transcription, mRNA translation, mRNA degradation, and protein degradation.
Transcription (transcription) of glutamate receptor associated with glutamate receptor
6) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.50 Pain Relevance 0.18
The GluR1-flip mRNA was not detected in the samples and the mRNAs for other splice variants did not exhibit significant changes.
Neg (not) Transcription (detected) of GluR1
7) Confidence 0.43 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.89 Pain Relevance 0.69
The mRNA levels of glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), AMPA receptor subunits (GluR1, GluR2, GluR3), NMDA receptor subunits (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) were confirmed in six regions of the male rat brain (the prefrontal cortex (PFC), cortex, caudate putamen (CPU), nucleus accumbens (Acb), hippocampus and hypothalamus.
Transcription (levels) of GluR1 in brain associated with nucleus accumbens, glutamate, glutamate receptor, nmda receptor and hippocampus
8) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.67
In the hypothalamus, the mRNA levels of GluR1, GluR3, mGluR1, mGluR3 and NR1 were significantly increased also after the administration of the highest MDMA dose, Figure 2C.
Transcription (levels) of GluR1 in hypothalamus
9) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0
The expressions of phospho-Ser845-GluR1 and c-fos mRNA (in striatum and cerebral cortex) are enhanced by administration of fluoxetine or 2-ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), a 5-HT6 receptor agonist.
Transcription (expressions) of GluR1 in striatum associated with agonist, cerebral cortex and fluoxetine
10) Confidence 0.18 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.17 Pain Relevance 0.80
Indeed, when we examined the amount of synaptosomal GluR1 expression 10 minutes following treatment with strong NMDA and co-application of weak NMDA and dopamine groups, we observed a significant reduction in the amount of GluR1 in synaptosomes (1±0.07, n?
Transcription (amount) of GluR1 associated with dopamine
11) Confidence 0.13 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0.23 Pain Relevance 0.37
The mRNA expression for the GluN1 subunit is also decreased in the hypothalamus of middle-aged female Sprague-Dawley rats and C57BL/6 mice, which may play a role in reproductive senescence (Zuo et al., 1996; Adjan et al., 2008).
Transcription (expression) of GluN1 in hypothalamus associated with aging
12) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.36 Pain Relevance 0.20
Growth hormone enhances the mRNA expressions of the GluN1 and GluN2A subunits in the hippocampus (Le Greves et al., 2002).
Transcription (expressions) of GluN1 in hippocampus associated with hippocampus
13) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.53 Pain Relevance 0.54

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