INT9494

Context Info Confidence 0.67 First Reported 1991 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 34 Total Number 39 Disease Relevance 17.77 Pain Relevance 6.26

extracellular space (Igf1) extracellular region (Igf1)

Anatomy Link Frequency sensory neuron 8 plasma 6 macrophage 2 mammary gland 2 spinal cord 2 Igf1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Nerve growth factor 9 100.00 agonist 59 99.92 cytokine 223 99.86 Calcitonin gene-related peptide 26 99.44 qutenza 17 99.20 Spinal cord 19 99.12 Inflammatory mediators 5 99.04 Inflammation 147 99.00 ischemia 14 97.92 Inflammatory stimuli 4 95.84

Disease Link Frequency Relevance Heat Frailty 34 99.92 INFLAMMATION 168 99.04 Pressure And Volume Under Development 4 99.02 Lung Cancer 16 98.96 Hypertrophic Cardiomyopathy 5 98.84 Pancreatitis 23 98.52 Wound Healing 46 98.44 Hypoxia 162 98.24 Cancer 110 98.20 Cv Unclassified Under Development 19 97.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Limaprost reduces motor disturbances by increasing the production of insulin-like growth factor I in rats subjected to spinal cord injury.

Positive_regulation (increasing) of Gene_expression (production) of insulin-like growth factor I in spinal cord associated with qutenza and spinal cord

1) Confidence 0.67 Published 2010 Journal Transl Res Section Title Doc Link 20970752 Disease Relevance 0.95 Pain Relevance 0.60

analog limaprost reduces SCI by increasing IGF-I production through sensory neuron stimulation.

Positive_regulation (increasing) of Gene_expression (production) of IGF-I in sensory neuron associated with frailty

2) Confidence 0.67 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.84 Pain Relevance 0.50

These observations strongly suggest that limaprost may increase the IGF-I production by stimulating sensory neurons in the spinal cord, thereby ameliorating compression-trauma-induced SCI through attenuation of inflammatory responses.

Spec (may) Positive_regulation (increase) of Gene_expression (production) of IGF-I in sensory neurons associated with inflammatory response, frailty, injury and spinal cord

3) Confidence 0.67 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.16 Pain Relevance 0.41

First, elevated levels of GH could account for the increased levels of IGF-1.

Positive_regulation (account) of Gene_expression (levels) of IGF-1

4) Confidence 0.65 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.67 Pain Relevance 0.03

Third, an increase in hepatic IGF-1 gene expression under the influence of inflammatory mediators or variability in the regulatory sequences responsible for its expression.

Positive_regulation (increase) of Gene_expression (expression) of IGF-1 associated with inflammatory mediators

5) Confidence 0.65 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.55 Pain Relevance 0.05

Blueberry and piroxicam supplementations were found to attenuate the kainic acid-induced increase in the expression of IL-1beta, TNF-alpha, and NF-kappaB, while only blueberry was able to augment the increased IGF-1 expression.

Positive_regulation (augment) of Gene_expression (expression) of IGF-1

6) Confidence 0.55 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.52 Pain Relevance 0.38

Blueberry and piroxicam supplementations were found to attenuate the kainic acid-induced increase in the expression of IL-1beta, TNF-alpha, and NF-kappaB, while only blueberry was able to augment the increased IGF-1 expression.

Positive_regulation (increased) of Gene_expression (expression) of IGF-1

7) Confidence 0.55 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.52 Pain Relevance 0.38

The levels of serum IGF-I and hepatic IGF-I gene expression were significantly less in animals treated with the combination of octreotide and tamoxifen than in animals treated with either agent alone (p < .01).

Positive_regulation (levels) of Gene_expression (expression) of IGF-I gene

8) Confidence 0.50 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.06 Pain Relevance 0.14

Discordant IGF-1 and fasting GH levels <1 ?

Positive_regulation (fasting) of Gene_expression (levels) of IGF-1

9) Confidence 0.49 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.13 Pain Relevance 0

It is likely that most of this clearance was of IGF-1 delivered into the CSF.

Positive_regulation (delivered) of Gene_expression (delivered) of IGF-1

10) Confidence 0.48 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.14 Pain Relevance 0

Seemingly, bulk flow of CSF plus any edema fluid formed within the parenchyma is needed to transport IGF-1 as widely as appears to be the case in the hypoxia-ischemia model [37].

Positive_regulation (transport) of Gene_expression (transport) of IGF-1 in parenchyma associated with pressure and volume under development, hypoxia and ischemia

11) Confidence 0.48 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.36 Pain Relevance 0.12

Growth hormone (GH) has been shown to protect the intestinal barrier integrity and to stimulate the production of insulin-like growth factor 1 (IGF-1), which inhibits the development of acute pancreatitis.

Positive_regulation (stimulate) of Gene_expression (production) of insulin-like growth factor 1 associated with pancreatitis

12) Confidence 0.47 Published 2009 Journal Growth Horm. IGF Res. Section Abstract Doc Link 19615927 Disease Relevance 0.55 Pain Relevance 0.10

Growth hormone (GH) has been shown to protect the intestinal barrier integrity and to stimulate the production of insulin-like growth factor 1 (IGF-1), which inhibits the development of acute pancreatitis.

Positive_regulation (stimulate) of Gene_expression (production) of IGF-1 associated with pancreatitis

13) Confidence 0.47 Published 2009 Journal Growth Horm. IGF Res. Section Abstract Doc Link 19615927 Disease Relevance 0.55 Pain Relevance 0.10

Overexpression of IGF-I transgene targeted to the mammary gland by placing it under the control of whey acidic protein promoter inhibits involution of the mammary epithelia after lactation, indicating that IGF-I acts as a survival factor for the mammary epithelia [19,20].

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IGF-I in mammary gland

14) Confidence 0.47 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.45 Pain Relevance 0.04

In view of that, it seems that our conclusions do not account for the phenomenon of statistically significant elevated IGF-1 levels, nor do they explain the role of IGF-1 in patients with an advanced form of stable ischaemic heart disease, as it is difficult to imagine that the local synthesis of IGF-I in the coronary vessel wall could increase systemic levels of this protein to such high levels.

Positive_regulation (elevated) of Gene_expression (levels) of IGF-1 in heart associated with coronary artery disease

15) Confidence 0.47 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.46 Pain Relevance 0

In contrast, elevated levels of GH in ambulatory animals inhibit the positive affect of IGF-I, indicating that in fact elevated GH in ambulatory animals may not be permissive to elevated IGF-I function, but that improved healing from IGF-I addition is not dependent on exogenously elevated GH levels.

Positive_regulation (elevated) of Gene_expression (function) of IGF-I

16) Confidence 0.47 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.08 Pain Relevance 0.03

Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.

Spec (might) Positive_regulation (increase) of Gene_expression (production) of IGF-I in sensory neurons

17) Confidence 0.46 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12

Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation.

Positive_regulation (increased) of Gene_expression (levels) of IGF-I in plasma

18) Confidence 0.46 Published 2008 Journal Growth Horm. IGF Res. Section Body Doc Link 17693108 Disease Relevance 0 Pain Relevance 0

These results indicate that maternal exercise significantly increases plasma levels of GH, IGF-I and IGFBP-3 in the late period of pregnancy but causes adverse effects on fetal growth.

Positive_regulation (increases) of Gene_expression (levels) of IGF-I in plasma

19) Confidence 0.45 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340176 Disease Relevance 0.15 Pain Relevance 0.08

The levels of serum IGF-I and hepatic IGF-I gene expression were significantly less in animals treated with the combination of octreotide and tamoxifen than in animals treated with either agent alone (p < .01).

Positive_regulation (levels) of Gene_expression (expression) of serum IGF-I

20) Confidence 0.44 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.06 Pain Relevance 0.14

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