INT9494
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Limaprost reduces motor disturbances by increasing the production of insulin-like growth factor I in rats subjected to spinal cord injury. | |||||||||||||||
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analog limaprost reduces SCI by increasing IGF-I production through sensory neuron stimulation. | |||||||||||||||
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These observations strongly suggest that limaprost may increase the IGF-I production by stimulating sensory neurons in the spinal cord, thereby ameliorating compression-trauma-induced SCI through attenuation of inflammatory responses. | |||||||||||||||
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First, elevated levels of GH could account for the increased levels of IGF-1. | |||||||||||||||
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Third, an increase in hepatic IGF-1 gene expression under the influence of inflammatory mediators or variability in the regulatory sequences responsible for its expression. | |||||||||||||||
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Blueberry and piroxicam supplementations were found to attenuate the kainic acid-induced increase in the expression of IL-1beta, TNF-alpha, and NF-kappaB, while only blueberry was able to augment the increased IGF-1 expression. | |||||||||||||||
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Blueberry and piroxicam supplementations were found to attenuate the kainic acid-induced increase in the expression of IL-1beta, TNF-alpha, and NF-kappaB, while only blueberry was able to augment the increased IGF-1 expression. | |||||||||||||||
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The levels of serum IGF-I and hepatic IGF-I gene expression were significantly less in animals treated with the combination of octreotide and tamoxifen than in animals treated with either agent alone (p < .01). | |||||||||||||||
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Discordant IGF-1 and fasting GH levels <1 ? | |||||||||||||||
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It is likely that most of this clearance was of IGF-1 delivered into the CSF. | |||||||||||||||
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Seemingly, bulk flow of CSF plus any edema fluid formed within the parenchyma is needed to transport IGF-1 as widely as appears to be the case in the hypoxia-ischemia model [37]. | |||||||||||||||
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Growth hormone (GH) has been shown to protect the intestinal barrier integrity and to stimulate the production of insulin-like growth factor 1 (IGF-1), which inhibits the development of acute pancreatitis. | |||||||||||||||
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Growth hormone (GH) has been shown to protect the intestinal barrier integrity and to stimulate the production of insulin-like growth factor 1 (IGF-1), which inhibits the development of acute pancreatitis. | |||||||||||||||
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Overexpression of IGF-I transgene targeted to the mammary gland by placing it under the control of whey acidic protein promoter inhibits involution of the mammary epithelia after lactation, indicating that IGF-I acts as a survival factor for the mammary epithelia [19,20]. | |||||||||||||||
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In view of that, it seems that our conclusions do not account for the phenomenon of statistically significant elevated IGF-1 levels, nor do they explain the role of IGF-1 in patients with an advanced form of stable ischaemic heart disease, as it is difficult to imagine that the local synthesis of IGF-I in the coronary vessel wall could increase systemic levels of this protein to such high levels. | |||||||||||||||
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In contrast, elevated levels of GH in ambulatory animals inhibit the positive affect of IGF-I, indicating that in fact elevated GH in ambulatory animals may not be permissive to elevated IGF-I function, but that improved healing from IGF-I addition is not dependent on exogenously elevated GH levels. | |||||||||||||||
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Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR. | |||||||||||||||
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Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation. | |||||||||||||||
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These results indicate that maternal exercise significantly increases plasma levels of GH, IGF-I and IGFBP-3 in the late period of pregnancy but causes adverse effects on fetal growth. | |||||||||||||||
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The levels of serum IGF-I and hepatic IGF-I gene expression were significantly less in animals treated with the combination of octreotide and tamoxifen than in animals treated with either agent alone (p < .01). | |||||||||||||||
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General Comments
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