INT94947

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.91
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
endothelial cells 2
spinal cord 2
lung 2
lobes 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 5 97.20 Very High Very High Very High
fluoxetine 2 96.48 Very High Very High Very High
sSRI 2 96.00 Very High Very High Very High
cINOD 7 94.16 High High
cytokine 37 93.72 High High
intrathecal 1 93.36 High High
Inflammatory mediators 6 91.92 High High
depression 5 91.76 High High
Neuropathic pain 2 91.12 High High
chemokine 8 90.92 High High
Disease Link Frequency Relevance Heat
Congenital Anomalies 2 100.00 Very High Very High Very High
Hyperoxia 98 99.98 Very High Very High Very High
Cancer 5 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 70 98.72 Very High Very High Very High
Shock 16 97.64 Very High Very High Very High
Obesity 2 94.68 High High
INFLAMMATION 102 92.72 High High
Depression 5 91.76 High High
Neuropathic Pain 3 91.12 High High
Pressure And Volume Under Development 7 90.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SNL resulted also in a massive induction of IL-6 mRNA expression in dorsal root ganglia and increased concentration of IL-6 in dorsal spinal cord.
Positive_regulation (induction) of Transcription (expression) of IL-6 in spinal cord associated with spinal cord
1) Confidence 0.67 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.63 Pain Relevance 0.88
There is a polymorphism of the IL-6 gene that will result in abnormalities in IL-6 transcription rate.
Positive_regulation (result) of Transcription (transcription) of IL-6 associated with congenital anomalies
2) Confidence 0.47 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 1.37 Pain Relevance 0.31
Immunohistochemical study revealed positive staining using an antihuman IL-6 antibody and Northern analysis showed increased IL-6 mRNA levels in the tumour.
Positive_regulation (increased) of Transcription (levels) of IL-6 associated with cancer
3) Confidence 0.45 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11298095 Disease Relevance 1.13 Pain Relevance 0.35
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Positive_regulation (induced) of Transcription (concentrations) of IL6 associated with hyperoxia
4) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.69 Pain Relevance 0.28
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Positive_regulation (increase) of Transcription (concentrations) of IL6 associated with hyperoxia
5) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.68 Pain Relevance 0.28
RT-PCR demonstrated that transcripts of IL-6 gene significantly increased 3 h after ligation in the nonembolized lobes.
Positive_regulation (increased) of Transcription (transcripts) of IL-6 gene in lobes
6) Confidence 0.39 Published 2006 Journal J. Surg. Res. Section Body Doc Link 16716357 Disease Relevance 0.07 Pain Relevance 0
Using this model, we found an increased expression of IL-6 mRNA in the sinusoidal endothelial cells predominantly at the periportal area.


Positive_regulation (increased) of Transcription (expression) of IL-6 in endothelial cells
7) Confidence 0.36 Published 2006 Journal J. Surg. Res. Section Body Doc Link 16716357 Disease Relevance 0.06 Pain Relevance 0
Furthermore, hypervolemia was associated with alveolar and endothelium damage as well as increased mRNA expression of IL-6, VCAM-1 and ICAM-1 in lung tissue.

• RMs reduced alveolar collapse regardless of volemic status. • During hypervolemia, RMs improved oxygenation and lung mechanics at the expense of alveolar capillary membrane damage, increased edema, and higher gene expression of inflammatory and fibrogenic mediators.

Positive_regulation (increased) of Transcription (expression) of IL-6 in lung associated with pressure and volume under development, pressure volume 2 under development, inflammation and shock
8) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.81 Pain Relevance 0.08
The results revealed that the mRNA expressions of IL-1beta, IL-6, IFNgamma, TNFalpha, and 5-HTT were higher in the depressed patients than those of the healthy controls.
Positive_regulation (higher) of Transcription (expressions) of IL-6
9) Confidence 0.03 Published 2006 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 16616982 Disease Relevance 0.47 Pain Relevance 0.85

General Comments

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