INT9495

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 11.87
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
neurons 8
skeletal muscles 6
mammary gland 2
plasma 2
long bones 2
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 6 100.00 Very High Very High Very High
neuralgia 8 99.74 Very High Very High Very High
nociceptor 4 99.74 Very High Very High Very High
fluoxetine 10 99.68 Very High Very High Very High
Hippocampus 10 99.40 Very High Very High Very High
Inflammatory mediators 2 99.04 Very High Very High Very High
Somatostatin 31 99.02 Very High Very High Very High
palliative 12 95.52 Very High Very High Very High
Painful diabetic neuropathy 4 94.32 High High
Inflammation 77 93.00 High High
Disease Link Frequency Relevance Heat
Appetite Loss 35 99.98 Very High Very High Very High
Diabetes Mellitus 12 99.84 Very High Very High Very High
Urological Neuroanatomy 7 99.68 Very High Very High Very High
Injury 8 99.56 Very High Very High Very High
Oligospermia 1 99.38 Very High Very High Very High
Aging 3 99.12 Very High Very High Very High
INFLAMMATION 82 99.04 Very High Very High Very High
Male Infertility 2 98.98 Very High Very High Very High
Cancer 300 98.96 Very High Very High Very High
Hypogonadotropic Hypogonadism 6 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This combination represents a novel pharmacological strategy for suppressing IGF-I gene expression that may be relevant to the design of clinical trials.
Negative_regulation (suppressing) of Gene_expression (expression) of IGF-I gene
1) Confidence 0.59 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0 Pain Relevance 0.13
We report here that the somatostatin analogue octreotide, previously demonstrated to reduce acromegalic levels of IGF-I towards normal, decreased serum IGF-I to 70 +/- 4% (mean +/- SD) of control values and hepatic IGF-I expression to 65 +/- 10% of control values in a short-term non-acromegalic rat model.
Negative_regulation (decreased) of Gene_expression (expression) of IGF-I associated with somatostatin
2) Confidence 0.59 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.08 Pain Relevance 0.17
There is a significant down-regulation in the expression of IGF-I and IGF-IR in the small DRG neurons of STZ rats by 59% and 71%, respectively.
Negative_regulation (down) of Gene_expression (expression) of IGF-I in neurons
3) Confidence 0.58 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.26 Pain Relevance 0.22
The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points.
Negative_regulation (inhibited) of Gene_expression (expression) of IGF1 associated with sprains and strains
4) Confidence 0.52 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 1.01 Pain Relevance 0.27
We recently reported that tamoxifen, a commonly used antiestrogen antineoplastic agent, significantly suppresses IGF-I gene expression and serum IGF-I levels.
Negative_regulation (suppresses) of Gene_expression (expression) of serum IGF-I
5) Confidence 0.51 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.09 Pain Relevance 0.18
There is a significant down-regulation in the expression of IGF-I and IGF-IR in the small DRG neurons of STZ rats by 59% and 71%, respectively.
Negative_regulation (regulation) of Gene_expression (expression) of IGF-I in neurons
6) Confidence 0.43 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.26 Pain Relevance 0.22
There is a significant down-regulation in the expression of IGF-I and IGF-IR in the small DRG neurons of STZ rats by 59% and 71%, respectively.
Negative_regulation (-) of Gene_expression (expression) of IGF-I in neurons
7) Confidence 0.43 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.26 Pain Relevance 0.22
Tamoxifen reduced serum IGF-I to 74 +/- 12% of control values and hepatic IGF-I expression to 46 +/- 9% of control values in this model, but the combination of octreotide and tamoxifen reduced serum IGF-I concentration to 49 +/- 10% of control values and hepatic IGF-I gene expression to 12 +/- 9% of control values.
Negative_regulation (reduced) of Gene_expression (expression) of IGF-I gene
8) Confidence 0.43 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.06 Pain Relevance 0.15
Tamoxifen reduced serum IGF-I to 74 +/- 12% of control values and hepatic IGF-I expression to 46 +/- 9% of control values in this model, but the combination of octreotide and tamoxifen reduced serum IGF-I concentration to 49 +/- 10% of control values and hepatic IGF-I gene expression to 12 +/- 9% of control values.
Negative_regulation (reduced) of Gene_expression (expression) of IGF-I
9) Confidence 0.43 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.07 Pain Relevance 0.16
We recently reported that tamoxifen, a commonly used antiestrogen antineoplastic agent, significantly suppresses IGF-I gene expression and serum IGF-I levels.
Negative_regulation (suppresses) of Gene_expression (expression) of IGF-I gene
10) Confidence 0.43 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.09 Pain Relevance 0.18
We report here that the somatostatin analogue octreotide, previously demonstrated to reduce acromegalic levels of IGF-I towards normal, decreased serum IGF-I to 70 +/- 4% (mean +/- SD) of control values and hepatic IGF-I expression to 65 +/- 10% of control values in a short-term non-acromegalic rat model.
Negative_regulation (reduce) of Gene_expression (expression) of IGF-I associated with somatostatin
11) Confidence 0.43 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.08 Pain Relevance 0.18
We report here that the somatostatin analogue octreotide, previously demonstrated to reduce acromegalic levels of IGF-I towards normal, decreased serum IGF-I to 70 +/- 4% (mean +/- SD) of control values and hepatic IGF-I expression to 65 +/- 10% of control values in a short-term non-acromegalic rat model.
Negative_regulation (reduce) of Gene_expression (levels) of IGF-I associated with somatostatin
12) Confidence 0.43 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.08 Pain Relevance 0.18
Preferential expression of IGF-I in small DRG neurons and down-regulation following injury.
Negative_regulation (down-regulation) of Gene_expression (expression) of IGF-I in neurons associated with neuralgia and injury
13) Confidence 0.43 Published 2002 Journal Neuroreport Section Title Doc Link 12352620 Disease Relevance 0.28 Pain Relevance 0.50
Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC.
Negative_regulation (decreased) of Gene_expression (levels) of IGF-1 mRNA in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine
14) Confidence 0.42 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.72 Pain Relevance 1.08
CONCLUSIONS: Sensory neuron activation might be lower in SHR than in WKY probably due to decreased production of cAMP in sensory neurons, explaining why IGF-I levels in plasma and tissues are lower in SHR than in WKY.


Negative_regulation (lower) of Gene_expression (levels) of IGF-I in plasma
15) Confidence 0.42 Published 2008 Journal Growth Horm. IGF Res. Section Body Doc Link 17693108 Disease Relevance 0 Pain Relevance 0
Discordant IGF-1 and glucose-suppressed GH levels <1 ?
Negative_regulation (suppressed) of Gene_expression (glucose) of IGF-1
16) Confidence 0.42 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.16 Pain Relevance 0
Grant et al. [8] was the first publication to report lack of IGF-1 expression in normal coronary arteries and its overexpresion in post-atherectomy specimens.
Negative_regulation (lack) of Gene_expression (expression) of IGF-1
17) Confidence 0.40 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.93 Pain Relevance 0
Measurement of IGF-I concentration in mammary tissues
Negative_regulation (Measurement) of Gene_expression (concentration) of IGF-I
18) Confidence 0.40 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.16 Pain Relevance 0
Overexpression of IGF-I transgene targeted to the mammary gland by placing it under the control of whey acidic protein promoter inhibits involution of the mammary epithelia after lactation, indicating that IGF-I acts as a survival factor for the mammary epithelia [19,20].
Negative_regulation (inhibits) of Gene_expression (Overexpression) of IGF-I in mammary gland
19) Confidence 0.40 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.53 Pain Relevance 0.04
Third, an increase in hepatic IGF-1 gene expression under the influence of inflammatory mediators or variability in the regulatory sequences responsible for its expression.
Negative_regulation (hepatic) of Gene_expression (expression) of IGF-1 associated with inflammatory mediators
20) Confidence 0.40 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.55 Pain Relevance 0.05

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