INT94952

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2011
Negated 3
Speculated 22
Reported most in Abstract
Documents 305
Total Number 327
Disease Relevance 197.83
Pain Relevance 186.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
microglia 47
spinal cord 33
spinal 26
neurons 25
DRG 13
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3027 100.00 Very High Very High Very High
Pain 950 100.00 Very High Very High Very High
cytokine 940 100.00 Very High Very High Very High
Hyperesthesia 7 100.00 Very High Very High Very High
Spinal cord 2344 99.96 Very High Very High Very High
ischemia 537 99.96 Very High Very High Very High
spinal dorsal horn 437 99.96 Very High Very High Very High
Dorsal horn 1162 99.92 Very High Very High Very High
Hyperalgesia 1085 99.92 Very High Very High Very High
Neuropathic pain 1074 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3239 100.00 Very High Very High Very High
Stress 267 100.00 Very High Very High Very High
Hypoxia 226 100.00 Very High Very High Very High
Nervous System Injury 2106 99.98 Very High Very High Very High
Cv Unclassified Under Development 398 99.96 Very High Very High Very High
Neuropathic Pain 2070 99.92 Very High Very High Very High
Hyperalgesia 1723 99.92 Very High Very High Very High
Myocardial Infarction 403 99.92 Very High Very High Very High
Pain 1305 99.90 Very High Very High Very High
Ganglion Cysts 523 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p38 activation was examined by p38 phosphorylation using a phosphorylated p38 antibody, and neuropathic pain-related behavior was evaluated before and after intrathecal infusion of a p38 inhibitor.
Spec (examined) Positive_regulation (activation) of p38
1) Confidence 0.70 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.08 Pain Relevance 0
This blockade prevented but did not reverse p38 activation in spinal microglia.
Positive_regulation (activation) of p38 in spinal
2) Confidence 0.70 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.05 Pain Relevance 0
CONCLUSIONS: After nerve injury, activity in the peripheral nerve is required for the induction but not the maintenance of p38 activation in spinal microglia.


Positive_regulation (activation) of p38 in nerve
3) Confidence 0.70 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0 Pain Relevance 0
Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model.
Positive_regulation (activation) of p38 in spinal associated with neuralgia, nervous system injury and sciatic nerve
4) Confidence 0.70 Published 2007 Journal Anesthesiology Section Title Doc Link 17667577 Disease Relevance 0.36 Pain Relevance 0.32
BACKGROUND: Current evidence indicates that p38 mitogen-activated protein kinase activation in spinal microglia contributes to the development of neuropathic pain.
Positive_regulation (activation) of p38 in microglia associated with neuropathic pain
5) Confidence 0.70 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17667577 Disease Relevance 0.36 Pain Relevance 0.22
The authors examined whether peripheral neural activity is necessary for p38 activation in spinal microglia.
Spec (whether) Positive_regulation (activation) of p38 in microglia
6) Confidence 0.70 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17667577 Disease Relevance 0.35 Pain Relevance 0.22
OBJECTIVE: To investigate the expression of activated p38 mitogen-activated protein kinases (p38 MAP kinase; p38) in the spinal cord and to determine the effect of intrathecal administration of a specific p38 inhibitor on pain in a lumbar disc herniation model and on motor function and hypoalgesia in a spinal canal stenosis (SCS) model.
Spec (investigate) Positive_regulation (activated) of p38 in spinal
7) Confidence 0.70 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0.10 Pain Relevance 0
CONCLUSIONS: Our findings suggest that activated p38 may play an important role in the involvement of microglia in the pathophysiology of pain following lumbar disc herniation and mechanical hypoalgesia, and motor nerve dysfunction of cauda equina following SCS.


Positive_regulation (activated) of p38 in microglia
8) Confidence 0.70 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0 Pain Relevance 0
This lesion results in activation of p38 in the L5 segment of the spinal cord, most prominently in the ipsilateral dorsal horn, starting soon after the lesion (<1 d) and persisting for >3 weeks.
Positive_regulation (activation) of p38 in dorsal horn associated with dorsal horn and spinal cord
9) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764087 Disease Relevance 0.59 Pain Relevance 0.73
The activated p38 in the spinal cord is restricted entirely to microglia; phospho-p38 colocalizes only with the microglial marker OX-42 and not with either the neuronal marker neuronal-specific nuclear protein or the astrocyte marker GFAP.
Positive_regulation (activated) of p38 in neuronal associated with spinal cord
10) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764087 Disease Relevance 0.63 Pain Relevance 0.80
The possible involvement of p38 mitogen-activated protein kinase activation in spinal cord and dorsal root ganglion (DRG) cells in the development of peripheral neuropathic pain has been explored.
Spec (possible) Positive_regulation (activation) of p38 in DRG associated with ganglion cysts, dorsal root ganglion, neuropathic pain and spinal cord
11) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764087 Disease Relevance 0.53 Pain Relevance 0.66
Because the reduction in neuropathic pain by p38 inhibition occurs before the appearance of p38 activation in DRG neurons, p38 activation in spinal cord microglia is likely to have a substantial role in the earliest phase of neuropathic pain.
Positive_regulation (activation) of p38 in DRG associated with dorsal root ganglion, neuropathic pain and spinal cord
12) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764087 Disease Relevance 0.82 Pain Relevance 1.12
Intrathecal pretreatment of FR167653 attenuated incision-induced mechanical allodynia from 1 h to day 2 and significantly reduced activation of p38 in the dorsal horn 1 day after plantar incision.
Positive_regulation (activation) of p38 in dorsal horn
13) Confidence 0.69 Published 2009 Journal Anesthesiology Section Body Doc Link 19104183 Disease Relevance 0.12 Pain Relevance 0
BACKGROUND: Recent studies have implicated the activation of stress-activated mitogen-activated protein kinase (MAPK) p38 in spinal microglial cells for development of neuropathic and inflammatory pain.
Positive_regulation (activation) of p38 in microglial cells associated with stress, ipn and neuropathic pain
14) Confidence 0.69 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19104183 Disease Relevance 0.37 Pain Relevance 0.34
Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia.
Positive_regulation (Activation) of p38 in spinal associated with pain and allodynia
15) Confidence 0.69 Published 2009 Journal Anesthesiology Section Title Doc Link 19104183 Disease Relevance 0.37 Pain Relevance 0.55
Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury.
Positive_regulation (Activation) of p38 in dorsal root ganglia associated with nervous system injury, inflammation and spinal cord
16) Confidence 0.69 Published 2002 Journal Neuroreport Section Title Doc Link 12499853 Disease Relevance 0.92 Pain Relevance 0.69
Activation of p38 mitogen-activated protein kinase (p38) in spinal microglia is implicated in spinal nociceptive processing.
Positive_regulation (Activation) of p38 in microglia associated with nociception
17) Confidence 0.69 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.39 Pain Relevance 0.40
Activation of p38 mitogen-activated protein kinase (p38) in spinal microglia is implicated in spinal nociceptive processing.
Positive_regulation (Activation) of p38 in microglia associated with nociception
18) Confidence 0.69 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.38 Pain Relevance 0.39
In the present study we examined antinociceptive effects of intrathecal (IT) administration of minocycline in experimental models of inflammation-evoked hyperalgesia in addition to the effect of minocycline on stimulation-induced activation of p38 in spinal microglia.
Spec (examined) Positive_regulation (activation) of p38 in microglia associated with hyperalgesia, inflammation, antinociceptive and intrathecal
19) Confidence 0.69 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.65 Pain Relevance 0.77
Taken together, these findings show that minocycline given IT produces a potent and consistent antinociception in models of tissue injury and inflammation-evoked pain, and they provide strong support for the idea that this effect is mediated by direct inhibition of spinal microglia and subsequent activation of p38 in these cells.
Positive_regulation (activation) of p38 in microglia associated with pain, antinociception, inflammation, injury and intrathecal
20) Confidence 0.69 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.70 Pain Relevance 0.84

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