INT94953

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 156
Total Number 159
Disease Relevance 104.77
Pain Relevance 91.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
joint 11
spinal 10
spinal cord 9
microglial cells 4
dorsal root ganglion 4
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2306 100.00 Very High Very High Very High
Spinal cord 975 100.00 Very High Very High Very High
intrathecal 942 100.00 Very High Very High Very High
cytokine 888 100.00 Very High Very High Very High
Arthritis 846 100.00 Very High Very High Very High
COX2 40 100.00 Very High Very High Very High
Kinase C 26 100.00 Very High Very High Very High
Thermal hyperalgesia 145 99.96 Very High Very High Very High
rheumatoid arthritis 401 99.92 Very High Very High Very High
Hyperalgesia 289 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Experimental Arthritis 481 100.00 Very High Very High Very High
Stress 174 100.00 Very High Very High Very High
Repression 15 100.00 Very High Very High Very High
Hyperalgesia 453 99.96 Very High Very High Very High
Rheumatoid Arthritis 401 99.92 Very High Very High Very High
Neurodegenerative Disease 21 99.78 Very High Very High Very High
Pain 633 99.64 Very High Very High Very High
Osteoarthritis 546 99.56 Very High Very High Very High
Cancer 127 99.56 Very High Very High Very High
INFLAMMATION 2374 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p38 activation was examined by p38 phosphorylation using a phosphorylated p38 antibody, and neuropathic pain-related behavior was evaluated before and after intrathecal infusion of a p38 inhibitor.
Negative_regulation (inhibitor) of p38
1) Confidence 0.59 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.08 Pain Relevance 0
We also examined the effects of intrathecal administration of a specific p38 inhibitor, FR167653, on nucleus pulposus-induced pain, hypoalgesia, and motor dysfunction following SCS.
Negative_regulation (inhibitor) of p38 in nucleus pulposus
2) Confidence 0.59 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0 Pain Relevance 0
In these rats, down-regulation of spinal p38beta, but not p38alpha, prevented nocifensive flinching evoked by intraplantar injection of formalin and hyperalgesia induced by activation of spinal neurokinin-1 receptors through intrathecal injection of substance P.
Negative_regulation (down-regulation) of p38alpha in spinal associated with hyperalgesia, substance p and intrathecal
3) Confidence 0.59 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748168 Disease Relevance 0.42 Pain Relevance 0.73
Both intraplantar formalin and intrathecal substance P produced an increase in spinal p38 phosphorylation and this phosphorylation (activation) was prevented when spinal p38beta, but not p38alpha, was down-regulated.
Negative_regulation (down-regulated) of p38alpha in spinal associated with substance p and intrathecal
4) Confidence 0.59 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748168 Disease Relevance 0.38 Pain Relevance 0.71
Therefore, p38 inhibition may be useful in treating postsurgical pain.


Negative_regulation (inhibition) of p38
5) Confidence 0.58 Published 2009 Journal Anesthesiology Section Body Doc Link 19104183 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Plantar incision-induced mechanical allodynia can be prevented by the p38 inhibitor.
Negative_regulation (inhibitor) of p38
6) Confidence 0.58 Published 2009 Journal Anesthesiology Section Body Doc Link 19104183 Disease Relevance 0.10 Pain Relevance 0
In addition, minocycline suppressed lipopolysaccharide-evoked P-p38 in cultured spinal microglial cells.
Negative_regulation (suppressed) of p38 in microglial cells
7) Confidence 0.58 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.84 Pain Relevance 1.10
Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia.
Negative_regulation (inhibiting) of p38 in spinal associated with hyperalgesia, inflammation and intrathecal
8) Confidence 0.58 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16307586 Disease Relevance 0.65 Pain Relevance 1.11
Intracisternal pretreatment with PD98059, a p44/42 MAPK inhibitor, or SB203580, a p38 MAPK inhibitor, significantly reduced the decrease in the threshold of air puffs ipsilateral to the IL-1beta injection site produced by 10 pg of IL-1beta.
Negative_regulation (inhibitor) of p38
9) Confidence 0.57 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16084017 Disease Relevance 0.28 Pain Relevance 0.38
These results indicate a potential therapeutic value of p38alpha MAPK inhibitors in the treatment of aberrant pain sensitivity produced by diabetes.
Negative_regulation (inhibitors) of p38alpha associated with pain and diabetes mellitus
10) Confidence 0.57 Published 2004 Journal Pain Section Abstract Doc Link 15157702 Disease Relevance 1.15 Pain Relevance 0.83
To assess the potential use of p38 kinase inhibition as a therapeutic strategy to manage fracture pain, the analgesic properties of SCIO-469, a p38alpha kinase inhibitor, were assessed in a rat fracture model and compared to other common analgesics.
Negative_regulation (inhibitor) of p38 associated with pain and analgesic
11) Confidence 0.57 Published 2009 Journal Pain Section Abstract Doc Link 19167815 Disease Relevance 1.01 Pain Relevance 1.07
Inhibition of p38 MAPK by SB203580 in the spinal cord attenuated but not reversed the tolerance to morphine analgesia.
Negative_regulation (Inhibition) of p38 in spinal cord associated with tolerance, analgesia, morphine and spinal cord
12) Confidence 0.56 Published 2006 Journal Brain Res. Section Abstract Doc Link 16403466 Disease Relevance 0 Pain Relevance 1.91
Repeated intrathecal administration of 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole (SB203580) (10 microg or 2 microg), a specific p38 inhibitor, 30 min before each morphine injection for 7 consecutive days significantly attenuated tolerance to morphine analgesia assessed by tail flick test.
Negative_regulation (inhibitor) of p38 in tail associated with tail-flick, tolerance, analgesia, morphine and intrathecal
13) Confidence 0.56 Published 2006 Journal Brain Res. Section Abstract Doc Link 16403466 Disease Relevance 0 Pain Relevance 1.86
We also tested the effect of intrathecal administration of a p38 mitogen-activated protein kinase inhibitor, SB203580.
Negative_regulation (inhibitor) of p38
14) Confidence 0.56 Published 2009 Journal Anesthesiology Section Body Doc Link 19672178 Disease Relevance 0.16 Pain Relevance 0
METHODS: Male Spargue-Dawley rats (weighing 300-350 g) were randomly assigned to 1 of the following 8 groups: control (CON, saline vehicle, n=9), SB 203580 (SB, a p38 MAPK inhibitor, n=6), MPC (n=6), IPC (n=9), SB+MPC, SB+IPC, MPC+SB, and IPC+SB (n=6).
Negative_regulation (inhibitor) of p38
15) Confidence 0.56 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17531118 Disease Relevance 0.18 Pain Relevance 0
We propose a model in which gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter of the CNS, may downregulate p38 MAPK activity to reduce peripheral production of proinflammatory cytokines in joints affected by RA.
Negative_regulation (downregulate) of p38 in joints associated with neurotransmitter, gaba, rheumatoid arthritis, central nervous system and cytokine
16) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.10 Pain Relevance 1.01
Injection of SD-282, a selective p38 inhibitor, but not PD98059, an ERK1/2 inhibitor, attenuated the prostaglanin E2 release.
Negative_regulation (inhibitor) of p38
17) Confidence 0.55 Published 2005 Journal Neuropeptides Section Abstract Doc Link 16176831 Disease Relevance 0.13 Pain Relevance 0.71
Recent studies suggest that p38 is also activated in spinal cord by injection of carrageenan or formalin into the footpad [4,22], and inhibition of p38 reduces pain behavior associated with the peripheral inflammation.
Negative_regulation (inhibition) of p38 in spinal cord associated with pain, inflammation and spinal cord
18) Confidence 0.55 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.70 Pain Relevance 0.85
The improvement in joint destruction after treatment with IT SB203580 suggests that the mediators and effector molecules in the joint might be affected by spinal p38 blockade.
Negative_regulation (blockade) of p38 in joint associated with intrathecal
19) Confidence 0.55 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.44 Pain Relevance 0.79
Our data suggest that p38 inhibition also suppresses TNF?
Negative_regulation (inhibition) of p38
20) Confidence 0.55 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.93 Pain Relevance 1.07

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