INT94967

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Context Info
Confidence 0.26
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.33
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
plasma 1
GABAergic neurons 1
Adrbk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 2 99.84 Very High Very High Very High
Raphe magnus 11 98.92 Very High Very High Very High
GABAergic 4 98.76 Very High Very High Very High
agonist 209 88.88 High High
adenocard 120 88.56 High High
opioid receptor 5 75.00 Quite High
tolerance 3 69.12 Quite High
Morphine 2 68.40 Quite High
Glutamate 1 63.04 Quite High
Enkephalin 1 58.68 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 89.76 High High
Cancer 22 89.40 High High
Leukemia 2 83.28 Quite High
Generalized Anxiety Disorder 1 63.80 Quite High
Nociception 1 38.04 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Hypoxia 10 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Neuroblastoma 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
treatment prevented GRK2 translocation to and decreased GRK2 association with the plasma membranes of these cells as a consequence of the activation of a sphingomyelinase-dependent pathway.
Localization (translocation) of GRK2 in plasma
1) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.18 Pain Relevance 0.25
An inhibitor of MAPK activation (PD98059) also caused inhibition of A3R phosphorylation, desensitization and internalization, probably by preventing the membrane translocation of GRK2.
Localization (translocation) of GRK2
2) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.08 Pain Relevance 0.11
Our results suggest that DAMGO selectively hyperpolarizes NRM GABAergic neurons by opening inwardly rectifying K(+) channels and that GRK2 mediates short-term homologous desensitization of mu-opioid receptors in NRM GABAergic neurons.
Localization (desensitization) of GRK2 in GABAergic neurons associated with raphe magnus, gabaergic and mu opioid receptor
3) Confidence 0.11 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299306 Disease Relevance 0.06 Pain Relevance 0.85

General Comments

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