INT94978

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.13
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
neurons 1
Adrbk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 6 99.68 Very High Very High Very High
tolerance 8 98.84 Very High Very High Very High
Opioid 6 98.42 Very High Very High Very High
tetrodotoxin 15 95.84 Very High Very High Very High
opioid receptor 8 94.68 High High
Analgesic 2 89.04 High High
Glutamate 7 88.16 High High
Kinase C 79 87.76 High High
Somatostatin 13 84.84 Quite High
tail-flick 1 81.84 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 76.36 Quite High
Convulsion 1 50.96 Quite High
Nash(non-alcoholic Steatohepatitis) 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When nimodipine was associated to the chronic opioid treatment, tolerance expression was prevented, and immunoreactivity levels of GRK2, GRK6 and beta-arrestin 2 recovered the control values.
Negative_regulation (recovered) of GRK2 associated with tolerance and opioid
1) Confidence 0.38 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.20
In addition, suramin (3 microM), an inhibitor of G-protein-coupled receptor kinase 2 (GRK2), caused a reduction in the desensitization.
Negative_regulation (inhibitor) of GRK2
2) Confidence 0.38 Published 2006 Journal Brain Res. Section Abstract Doc Link 16879804 Disease Relevance 0.13 Pain Relevance 0.62
In D110A,K220RGRK2-transfected neurons the R2/R1 ratio difference was dramatically reduced indicating that inhibition of endogenous GRK2 attenuates M1 mACh receptor desensitization under all conditions, including those where the extent of receptor desensitization was increased by picrotoxin treatment (see Fig. 3e).
Negative_regulation (inhibition) of GRK2 in neurons
3) Confidence 0.24 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.14
However, inhibition of GRK2-as5 during recycling and reinternalization of the muOR did not attenuate these processes.
Negative_regulation (inhibition) of GRK2
4) Confidence 0.14 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16081410 Disease Relevance 0 Pain Relevance 0.23
Morphine-induced internalization was completely blocked when GRK2-as5 activity was inhibited before morphine application.
Negative_regulation (inhibited) of GRK2 associated with morphine
5) Confidence 0.14 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16081410 Disease Relevance 0 Pain Relevance 0.23
In the present study we have developed an engineered version of GRK2 that is specifically and reversibly inhibited by the substituted nucleotide analog 1-naphthyl-PP1 (1Na-PP1), and we explored GRK2 function in regulated internalization of the mu-opioid receptor (muOR).
Negative_regulation (inhibited) of GRK2 associated with opioid receptor
6) Confidence 0.10 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16081410 Disease Relevance 0 Pain Relevance 0.05

General Comments

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