INT94979

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2001
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.51
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
brain 3
cerebral cortex 1
Arrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 30 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
tolerance 22 99.58 Very High Very High Very High
Central grey 9 99.40 Very High Very High Very High
Analgesic 4 99.38 Very High Very High Very High
opioid receptor 23 98.72 Very High Very High Very High
cerebral cortex 10 98.44 Very High Very High Very High
antagonist 2 92.64 High High
Opioid 20 92.56 High High
Nicotine 5 92.40 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 9 99.40 Very High Very High Very High
Nicotine Addiction 4 90.60 High High
Pain 1 63.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute morphine administration had no significant effect on beta-arrestin 1 or beta-arrestin 2 mRNA level in periaqueductal gray and cerebral cortex.
Neg (no) Regulation (effect) of beta-arrestin 2 in cerebral cortex associated with cerebral cortex, central grey and morphine
1) Confidence 0.54 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.19 Pain Relevance 1.28
Regulation of mu-opioid receptors, G-protein-coupled receptor kinases and beta-arrestin 2 in the rat brain after chronic opioid receptor antagonism.
Regulation (Regulation) of beta-arrestin 2 in brain associated with mu opioid receptor and opioid receptor
2) Confidence 0.54 Published 2002 Journal Neuroscience Section Title Doc Link 12044452 Disease Relevance 0.06 Pain Relevance 0.82
Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphine.
Regulation (regulation) of beta-arrestin 2 in brain associated with morphine
3) Confidence 0.40 Published 2003 Journal Neuroscience Section Title Doc Link 12614678 Disease Relevance 0 Pain Relevance 0.74
These data indicate that GRK2, GRK3, GRK6 and beta-arrestin 2 are involved in the short- and long-term adaptive changes in mu-opioid receptor activity, contributing to tolerance development in living animals.
Regulation (involved) of beta-arrestin 2 associated with tolerance and opioid receptor
4) Confidence 0.36 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.17
In the current study, we investigated the potential regulatory effects of morphine administration on beta-arrestin 1 and beta-arrestin 2 mRNA levels in different brain regions in rat using in situ hybridization method.
Spec (investigated) Regulation (effects) of beta-arrestin 2 in brain associated with morphine
5) Confidence 0.24 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0 Pain Relevance 0.76
In a logistic regression model controlling for OPRM1 genotype, treatment type, and other covariates, we found no significant main effect of ARRB2 genotype on abstinence at either end of treatment or 6-month follow-up.
Neg (no) Regulation (effect) of ARRB2
6) Confidence 0.22 Published 2007 Journal Nicotine Tob. Res. Section Abstract Doc Link 17978999 Disease Relevance 0.25 Pain Relevance 0.51
Acute and chronic treatment with sufentanil induced analgesic tolerance, associated with up-regulation of GRK2, GRK6, and beta-arrestin 2.
Regulation (regulation) of beta-arrestin 2 associated with analgesic and tolerance
7) Confidence 0.21 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox