INT94981

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 17
Disease Relevance 2.11
Pain Relevance 11.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
cerebral cortex 2
brain 2
neurons 1
striatum 1
locus coeruleus 1
Arrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 31 99.84 Very High Very High Very High
cerebral cortex 11 99.84 Very High Very High Very High
analgesia 4 99.84 Very High Very High Very High
mu opioid receptor 6 99.80 Very High Very High Very High
Morphine 62 99.64 Very High Very High Very High
Opioid 19 99.16 Very High Very High Very High
tolerance 25 99.04 Very High Very High Very High
MU agonist 3 98.74 Very High Very High Very High
opiate 5 98.56 Very High Very High Very High
Hippocampus 8 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 31 99.84 Very High Very High Very High
Pain 2 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray.
Gene_expression (overexpressing) of beta-arrestin 2 associated with central grey, analgesia and morphine
1) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16563622 Disease Relevance 0.68 Pain Relevance 1.34
In locus coeruleus, both acute and chronic morphine treatments resulted in significant decreases (over 50%) in beta-arrestin 1 mRNA level but failed to induce any change in the level of beta-arrestin 2 gene expression.
Gene_expression (expression) of beta-arrestin 2 in locus coeruleus associated with locus ceruleus and morphine
2) Confidence 0.68 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.17 Pain Relevance 1.21
Our results thus demonstrated for the first time that opiate administration regulates level of beta-arrestin mRNAs in brain and the expression of beta-arrestin 1 and beta-arrestin 2 subtypes is differentially regulated in locus coeruleus, periaqueductal gray, and cerebral cortex by morphine.
Gene_expression (expression) of beta-arrestin 2 in cerebral cortex associated with locus ceruleus, opiate, cerebral cortex, central grey and morphine
3) Confidence 0.68 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.25 Pain Relevance 1.34
Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphine.
Gene_expression (expression) of beta-arrestin 2 in brain associated with morphine
4) Confidence 0.68 Published 2003 Journal Neuroscience Section Title Doc Link 12614678 Disease Relevance 0 Pain Relevance 0.75
We have evaluated the respiratory depressant and antinociceptive effects of the mu-opioid agonist sufentanil, the density of brain mu-opioid receptors, and the expression of G-protein-coupled receptor kinases and beta-arrestin 2 in cerebral cortex and striatum, following sustained opioid receptor blockade.
Gene_expression (expression) of beta-arrestin 2 in cerebral cortex associated with mu agonist, mu opioid receptor, opioid receptor, cerebral cortex and antinociceptive
5) Confidence 0.68 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044452 Disease Relevance 0.06 Pain Relevance 0.85
The expression of beta-arrestin 2 mRNA and protein significantly decreased in group M as compared with group NS (P < 0.01).
Gene_expression (expression) of beta-arrestin 2 mRNA
6) Confidence 0.66 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19615194 Disease Relevance 0 Pain Relevance 0
Compared with group M, the expressions of beta-arrestin 2 mRNA and protein were significantly elevated in group MF2 and MF3 (P < 0.05 or 0.01), but there was no significant change in group MF1 (P > 0.05).
Gene_expression (expressions) of beta-arrestin 2 mRNA
7) Confidence 0.66 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19615194 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Fentanyl at 6 and 12 microg/kg can partly inhibit morphine tolerance through an increased expression of mu-receptor and beta-arrestin 2 in periaqueductal gray of morphine-tolerant rats.


Gene_expression (expression) of beta-arrestin 2
8) Confidence 0.66 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19615194 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate the effect of fentanyl upon the expression of mu-receptor and beta-arrestin 2 in peri-aqueductal gray of morphine-tolerant rats.
Spec (investigate) Gene_expression (expression) of beta-arrestin 2 associated with morphine
9) Confidence 0.66 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 19615194 Disease Relevance 0.07 Pain Relevance 0.21
We identified elevated expression of the beta-arrestin 2 gene (Arrb2) in the striatum and the hippocampus of ethanol-preferring AA rats compared to their nonpreferring counterpart ANA line.
Gene_expression (expression) of beta-arrestin 2 in hippocampus associated with hippocampus
10) Confidence 0.63 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.22
In the present study beta-arrestin 2 overexpression was induced by adenovirus at PAG of rats.
Gene_expression (overexpression) of beta-arrestin 2 associated with central grey
11) Confidence 0.61 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16563622 Disease Relevance 0.70 Pain Relevance 1.35
Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity.
Gene_expression (expression) of beta-arrestin 2 in brain associated with tolerance and opioid
12) Confidence 0.53 Published 2001 Journal J. Neurochem. Section Title Doc Link 11299311 Disease Relevance 0 Pain Relevance 0.89
[Effect of fentanyl on expression of mu-receptor and beta-arrestin 2 in periaqueductal gray of rats tolerant to morphine].
Gene_expression (expression) of beta-arrestin 2 associated with central grey and morphine
13) Confidence 0.51 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 19615194 Disease Relevance 0.10 Pain Relevance 0.24
Periaqueductal gray was removed for determination of the expression of mRNA (RT-PCR) and protein (Western-blot) of mu-receptor and beta-arrestin 2.
Gene_expression (expression) of beta-arrestin 2
14) Confidence 0.51 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19615194 Disease Relevance 0 Pain Relevance 0
When nimodipine was associated to the chronic opioid treatment, tolerance expression was prevented, and immunoreactivity levels of GRK2, GRK6 and beta-arrestin 2 recovered the control values.
Gene_expression (levels) of beta-arrestin 2 associated with tolerance and opioid
15) Confidence 0.48 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.23
Chronic treatment with DAMGO or methadone produced internalization of enhanced yellow fluorescent protein-tagged MOR expressed in hippocampal neurons within hours, whereas morphine produced internalization much more slowly, even when accompanied by overexpression of beta-arrestin-2.
Gene_expression (overexpression) of beta-arrestin-2 in neurons associated with opioid receptor, methadone and morphine
16) Confidence 0.43 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11752206 Disease Relevance 0 Pain Relevance 1.28
We have evaluated the respiratory depressant and antinociceptive effects of the mu-opioid agonist sufentanil, the density of brain mu-opioid receptors, and the expression of G-protein-coupled receptor kinases and beta-arrestin 2 in cerebral cortex and striatum, following sustained opioid receptor blockade.
Gene_expression (expression) of beta-arrestin 2 in striatum associated with mu agonist, mu opioid receptor, opioid receptor, cerebral cortex and antinociceptive
17) Confidence 0.23 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044452 Disease Relevance 0.06 Pain Relevance 0.85

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