INT94983

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2001
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
brain 1
hippocampus 1
Arrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 20 99.76 Very High Very High Very High
Central grey 6 99.56 Very High Very High Very High
Hippocampus 4 99.36 Very High Very High Very High
tolerance 12 98.54 Very High Very High Very High
cerebral cortex 6 98.20 Very High Very High Very High
Opioid 8 98.12 Very High Very High Very High
Analgesic 2 88.44 High High
opioid receptor 9 88.24 High High
Locus ceruleus 4 86.64 High High
narcan 2 84.72 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that the acute morphine administration (10 mg/kg) resulted in approximately 30% reduction in both beta-arrestin 1 and beta-arrestin 2 mRNA levels in hippocampus while the chronic morphine treatment (10 mg/kg, b.i.d., for 9 days) caused no significant change in level of either beta-arrestin mRNA.
Negative_regulation (reduction) of beta-arrestin 2 in hippocampus associated with hippocampus and morphine
1) Confidence 0.52 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.06 Pain Relevance 0.97
However, after chronic morphine treatment, beta-arrestin 2 mRNA level decreased by 40% in periaqueductal gray and increased by 25% in cerebral cortex, in strong contrast to the unchanged beta-arrestin 1 mRNA level in these two brain regions.
Negative_regulation (decreased) of beta-arrestin 2 in brain associated with cerebral cortex, central grey and morphine
2) Confidence 0.38 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.20 Pain Relevance 1.31
When nimodipine was associated to the chronic opioid treatment, tolerance expression was prevented, and immunoreactivity levels of GRK2, GRK6 and beta-arrestin 2 recovered the control values.
Negative_regulation (recovered) of beta-arrestin 2 associated with tolerance and opioid
3) Confidence 0.34 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox