INT94985

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2003
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 4
Disease Relevance 0.43
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
brain 4
cerebral cortex 2
locus coeruleus 2
Arrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 6 99.84 Very High Very High Very High
Morphine 30 99.32 Very High Very High Very High
Central grey 9 99.16 Very High Very High Very High
Opioid 9 99.16 Very High Very High Very High
tolerance 14 98.88 Very High Very High Very High
opiate 3 98.56 Very High Very High Very High
cerebral cortex 9 98.16 Very High Very High Very High
opioid receptor 11 94.80 High High
Hippocampus 6 94.64 High High
agonist 5 94.16 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 9 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results thus demonstrated for the first time that opiate administration regulates level of beta-arrestin mRNAs in brain and the expression of beta-arrestin 1 and beta-arrestin 2 subtypes is differentially regulated in locus coeruleus, periaqueductal gray, and cerebral cortex by morphine.
Regulation (regulated) of Gene_expression (expression) of beta-arrestin 2 in cerebral cortex associated with locus ceruleus, opiate, cerebral cortex, central grey and morphine
1) Confidence 0.40 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.25 Pain Relevance 1.35
Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphine.
Regulation (regulation) of Gene_expression (expression) of beta-arrestin 2 in brain associated with morphine
2) Confidence 0.40 Published 2003 Journal Neuroscience Section Title Doc Link 12614678 Disease Relevance 0 Pain Relevance 0.75
Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity.
Regulation (Changes) of Gene_expression (expression) of beta-arrestin 2 in brain associated with tolerance and opioid
3) Confidence 0.36 Published 2001 Journal J. Neurochem. Section Title Doc Link 11299311 Disease Relevance 0 Pain Relevance 0.89
In locus coeruleus, both acute and chronic morphine treatments resulted in significant decreases (over 50%) in beta-arrestin 1 mRNA level but failed to induce any change in the level of beta-arrestin 2 gene expression.
Regulation (change) of Gene_expression (expression) of beta-arrestin 2 in locus coeruleus associated with locus ceruleus and morphine
4) Confidence 0.24 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.17 Pain Relevance 1.22

General Comments

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