INT94986

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.30
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
brain 2
hippocampus 1
Arrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 14 100.00 Very High Very High Very High
Morphine 28 99.76 Very High Very High Very High
tolerance 12 99.64 Very High Very High Very High
cerebral cortex 7 99.56 Very High Very High Very High
Analgesic 2 99.44 Very High Very High Very High
Hippocampus 4 99.40 Very High Very High Very High
narcan 3 99.30 Very High Very High Very High
withdrawal 2 98.18 Very High Very High Very High
antinociception 2 95.48 Very High Very High Very High
Pain 1 94.44 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 100.00 Very High Very High Very High
Pain 1 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, after chronic morphine treatment, beta-arrestin 2 mRNA level decreased by 40% in periaqueductal gray and increased by 25% in cerebral cortex, in strong contrast to the unchanged beta-arrestin 1 mRNA level in these two brain regions.
Positive_regulation (increased) of beta-arrestin 2 in brain associated with cerebral cortex, central grey and morphine
1) Confidence 0.61 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.25 Pain Relevance 1.38
Furthermore, spontaneous or naloxone-precipitated withdrawal of morphine that did not affect the level of beta-arrestin 1 mRNA resulted in an aberrant increase (100% over control) in beta-arrestin 2 mRNA level in hippocampus.
Positive_regulation (increase) of beta-arrestin 2 in hippocampus associated with narcan, hippocampus, withdrawal and morphine
2) Confidence 0.61 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.25 Pain Relevance 1.39
Moreover, chronic treatment with either naltrexone (120 microg/h) or naloxone (120 microg/h) caused significant increases in the expression levels of G-protein-coupled receptor kinases types 2, 3, and 6, and of beta-arrestin 2 in brain cortex and striatum.
Positive_regulation (increases) of beta-arrestin 2 in brain associated with narcan
3) Confidence 0.61 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044452 Disease Relevance 0.09 Pain Relevance 0.94
Acute and chronic treatment with sufentanil induced analgesic tolerance, associated with up-regulation of GRK2, GRK6, and beta-arrestin 2.
Positive_regulation (up-regulation) of beta-arrestin 2 associated with analgesic and tolerance
4) Confidence 0.40 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.18
In the present study beta-arrestin 2 overexpression was induced by adenovirus at PAG of rats.
Positive_regulation (induced) of beta-arrestin 2 associated with central grey
5) Confidence 0.37 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16563622 Disease Relevance 0.71 Pain Relevance 1.36

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