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Context Info
Confidence 0.24
First Reported 2001
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) signal transducer activity (Oprm1)
Arrb2 (Rattus norvegicus)
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Opioid 6 99.36 Very High Very High Very High
tolerance 8 99.08 Very High Very High Very High
Calcium channel 1 90.00 High High
antinociception 1 79.28 Quite High
tail-flick 1 76.32 Quite High
Analgesic 2 61.84 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The focus of the present study was to determine a role for G protein-coupled receptor kinases (GRKs) and beta-arrestin 2 in agonist-induced mu-opioid receptor signalling modulation during chronic opioid tolerance and supersensitivity.
beta-arrestin 2 Spec (determine) Regulation (role) of Regulation (modulation) of mu-opioid receptor associated with tolerance, agonist, opioid receptor and opioid
1) Confidence 0.24 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 0.98

General Comments

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