INT94998

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 16
Disease Relevance 12.33
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 2
blood 1
lungs 1
microglia 1
IL10 (Sus scrofa)
Pain Term Frequency Confidence Heat
cytokine 365 99.98 Very High Very High Very High
Inflammation 454 99.80 Very High Very High Very High
Catecholamine 3 99.32 Very High Very High Very High
ischemia 323 93.64 High High
Inflammatory response 218 92.64 High High
cerebral cortex 80 78.32 Quite High
cva 87 66.12 Quite High
Inflammatory marker 15 51.28 Quite High
Inflammatory mediators 16 41.16 Quite Low
cINOD 3 40.32 Quite Low
Disease Term Frequency Confidence Heat
Hypothermia 528 99.80 Very High Very High Very High
INFLAMMATION 687 99.80 Very High Very High Very High
Cancer 29 99.76 Very High Very High Very High
Necrosis 45 99.52 Very High Very High Very High
Myocardial Infarction 336 99.28 Very High Very High Very High
Infection 5 99.16 Very High Very High Very High
Injury 227 97.50 Very High Very High Very High
Adhesions 35 96.72 Very High Very High Very High
Cv General 4 Under Development 192 93.64 High High
Stress 13 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-8, IL-10 and TNF-alpha levels and C-reactive protein (CRP) concentrations were measured in plasma samples.
Gene_expression (levels) of IL-10 in plasma
1) Confidence 0.49 Published 2001 Journal Acta Anaesthesiol Scand Section Body Doc Link 11300377 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: The CPB procedure elicited a systemic inflammatory response in terms of significantly elevated plasma levels of IL-8 and IL-10.
Gene_expression (levels) of IL-10 in plasma
2) Confidence 0.44 Published 2001 Journal Acta Anaesthesiol Scand Section Body Doc Link 11300377 Disease Relevance 0.05 Pain Relevance 0
In a first series of studies, PRRSV was shown to be a poor inducer of TNF-alpha and IFN-alpha in the lungs, whereas IL-1 and the anti-inflammatory cytokine IL-10 were produced consistently during infection.
Gene_expression (produced) of IL-10 in lungs associated with inflammation, infection and cytokine
3) Confidence 0.29 Published 2004 Journal Vet. Immunol. Immunopathol. Section Abstract Doc Link 15507303 Disease Relevance 0.67 Pain Relevance 0.21
We suggest that at early time points following trauma, circulatory and the neuro-endocrine derangements lead to the production of catecholamines, which in turn induce this later production of IL-10 [29], [33], [59], [60].
Gene_expression (production) of IL-10 associated with catecholamine and injury
4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794373 Disease Relevance 0.98 Pain Relevance 0.55
From our data we conclude that mild hypothermia initiated after successful resuscitation from cardiac arrest reduces pro-inflammatory cytokine, IL-10, and ICAM-1 mRNA expression compared to normothermia.
Gene_expression (expression) of IL-10 associated with hypothermia, inflammation, myocardial infarction and cytokine
5) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 2.04 Pain Relevance 0.53
Comparably, we found less upregulation of IL-10 mRNA expression in the cerebral tissue in the hypothermia group compared to normothermia after successful CPR.
Gene_expression (expression) of IL-10 mRNA associated with hypothermia
6) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 1.56 Pain Relevance 0.40
While mild hypothermia has been shown to increase plasma IL-10 concentration in endotoxemic rats, thus potentially mediating the anti-inflammatory effects of hypothermia [36,37], Matsui et al. [38] and Russwurm et al. [39] have previously demonstrated that mild hypothermia inhibits IL-10 production in peripheral blood mononuclear cells.
Gene_expression (production) of IL-10 in blood associated with hypothermia and inflammation
7) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 1.82 Pain Relevance 0.45
Interestingly, in lipopolysaccharide-activated cultured microglia cells isolated from rats, hypothermia has also been found to reduce production of IL-6, IL-10, and nitric oxide, suggesting that the neuroprotective effects of hypothermia might involve not only the inhibition of pro-inflammatory factors, but also the inhibition of anti-inflammatory factor(s) [40].
Gene_expression (production) of IL-10 in microglia associated with hypothermia and inflammation
8) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 1.61 Pain Relevance 0.45
8.7 ± 4.0, IL-6 4.3 ± 2.6, IL-10 2.5 ± 1.6, TNF?
Gene_expression (2.5) of IL-10
9) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 0.43 Pain Relevance 0.19
1.7 ± 1.0, IL-6 2.2 ± 1.1, IL-10 0.8 ± 0.4, TNF?
Gene_expression (0.8) of IL-10
10) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 0.48 Pain Relevance 0.19
1.7 ± 1.0, IL-6 2.2 ± 1.1, IL-10 0.8 ± 0.4, TNF?
Gene_expression (0.4) of IL-10
11) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 0.48 Pain Relevance 0.19
8.7 ± 4.0, IL-6 4.3 ± 2.6, IL-10 2.5 ± 1.6, TNF?
Gene_expression (1.6) of IL-10
12) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 0.43 Pain Relevance 0.19
Higher circulating levels of TNF, IL-6, IL-10, and NO2-/NO3- are found in septic patients [70], [75]–[77].
Gene_expression (levels) of IL-10
13) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794373 Disease Relevance 0.87 Pain Relevance 0.18
Interestingly, IL-10 levels in the non-survivors in Group B were significantly lower than those of the non-survivors in Group A.
Gene_expression (levels) of IL-10
14) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794373 Disease Relevance 0 Pain Relevance 0.11
These results were unexpected and contrasted to findings in an endotoxin mouse model, where lower TNF-alpha and IL-1beta and higher IL-10 levels in CO-treated animals compared with controls were found [5].
Gene_expression (levels) of IL-10
15) Confidence 0.13 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2518540 Disease Relevance 0.34 Pain Relevance 0.30
Serum and BAL levels (ng/ml) of IL-1, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-?
Gene_expression (Serum) of IL-10 associated with necrosis and cancer
16) Confidence 0.12 Published 2007 Journal Crit Care Section Body Doc Link PMC2151879 Disease Relevance 0.48 Pain Relevance 0.05

General Comments

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