INT95

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 11.95
Pain Relevance 14.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
heart 4
blood 2
dorsal 1
caudal artery 1
brains 1
Adrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 8 100.00 Very High Very High Very High
Catecholamine 15 99.84 Very High Very High Very High
fluoxetine 5 99.74 Very High Very High Very High
anesthesia 24 99.68 Very High Very High Very High
Dopamine 8 99.66 Very High Very High Very High
Enkephalin 2 99.62 Very High Very High Very High
noradrenaline 20 99.48 Very High Very High Very High
amygdala 4 99.40 Very High Very High Very High
Dynorphin 1 99.32 Very High Very High Very High
IPN 3 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 2 99.96 Very High Very High Very High
Sprains And Strains 5 99.88 Very High Very High Very High
Rheumatoid Arthritis 12 99.84 Very High Very High Very High
Necrosis 1 99.82 Very High Very High Very High
Cancer 1 99.64 Very High Very High Very High
Heart Rate Under Development 8 99.58 Very High Very High Very High
Thyroid Disease 6 99.52 Very High Very High Very High
Arrhythmia Under Development 6 99.44 Very High Very High Very High
Herpes Zoster 11 99.02 Very High Very High Very High
Cluster Headache 14 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This may be due to up-regulated beta-receptor sensitivity, secondary to reduced sympathetic outflow and a primary autonomic disturbance in CH.
Positive_regulation (up-regulated) of beta-receptor in autonomic associated with cluster headache
1) Confidence 0.62 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16776698 Disease Relevance 0.81 Pain Relevance 0.79
The hemodynamic responses to blood loss amounting to 25 per cent of estimated blood volume, and its subsequent replacement, were studied before and after induction of beta-receptor blockade.
Positive_regulation (induction) of beta-receptor in blood associated with pressure volume 2 under development
2) Confidence 0.59 Published 1976 Journal Anesthesiology Section Abstract Doc Link 9020 Disease Relevance 0.34 Pain Relevance 0.37
To prevent hypotension during spinal anesthesia in elderly people, it is advisable to employ the treatment for upregulation of beta-receptor before anesthesia and the administration of alpha . beta-receptor, epinephrine and dopamine for control of blood pressure during spinal anesthesia.
Positive_regulation (upregulation) of beta-receptor in blood associated with dopamine, anesthesia and pressure volume 2 under development
3) Confidence 0.59 Published 1993 Journal Masui Section Abstract Doc Link 8350483 Disease Relevance 0.72 Pain Relevance 0.95
This increase in heart rate may be secondary to increased beta receptor numbers or increased receptor sensitivity.
Positive_regulation (increased) of beta receptor in heart associated with heart rate under development
4) Confidence 0.58 Published 1987 Journal Am. J. Cardiol. Section Abstract Doc Link 2883874 Disease Relevance 0.53 Pain Relevance 0.77
It seems that the ability of these antidepressants to potentiate the amnesic effect of scopolamine is unrelated to their effect on beta-1-adrenoceptor number in the amygdala and that the extent of the antidepressant-induced amygdaloid beta-1-adrenoceptor down-regulation is not sufficient, by itself, to cause a deficit in an inhibitory avoidance task.
Positive_regulation (effect) of beta-1-adrenoceptor in amygdala associated with antidepressant and amygdala
5) Confidence 0.50 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9718593 Disease Relevance 0 Pain Relevance 0.48
Short-term treatment with fluoxetine decreased the number of beta-adrenergic receptors (17%) while long-term treatment with fluoxetine elicited an increase (14%) in beta-AR-binding.
Positive_regulation (increase) of beta-AR-binding associated with fluoxetine
6) Confidence 0.47 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.23 Pain Relevance 0.39
Also in the rat caudal artery and monkey pial artery a significant enhancement of contraction was seen during burst simulation, whereas in the rabbit facial vein no significant difference in dilatation through beta-receptor activation was obtained.
Positive_regulation (activation) of beta-receptor in caudal artery
7) Confidence 0.46 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1585816 Disease Relevance 0 Pain Relevance 0.15
We investigated whether OPR stimulation influences the effects of beta-adrenergic receptor (beta-AR) stimulation in the isolated, isovolumic rat heart and whether the mechanism of such an interaction involves both beta-AR subtypes or an alteration in beta-AR-mediated increase in cAMP.
Positive_regulation (stimulation) of beta-AR in heart
8) Confidence 0.46 Published 1997 Journal Circulation Section Abstract Doc Link 9133523 Disease Relevance 0 Pain Relevance 0.35
We investigated whether OPR stimulation influences the effects of beta-adrenergic receptor (beta-AR) stimulation in the isolated, isovolumic rat heart and whether the mechanism of such an interaction involves both beta-AR subtypes or an alteration in beta-AR-mediated increase in cAMP.
Positive_regulation (increase) of beta-AR-mediated in heart
9) Confidence 0.43 Published 1997 Journal Circulation Section Abstract Doc Link 9133523 Disease Relevance 0 Pain Relevance 0.33
The elevated beta-receptor responsiveness to adrenergic stimuli makes subjects with the primary hyperkinetic cardiac syndrome ideal for studying the electrical and dynamic responses of the heart to sympathetic activation. 2.
Positive_regulation (elevated) of beta-receptor in heart associated with syndrome
10) Confidence 0.42 Published 1975 Journal Clin Sci Mol Med Suppl Section Abstract Doc Link 802642 Disease Relevance 0.43 Pain Relevance 0.08
The average glycerol increase was significantly higher in CH patients (121% +/- 48) than in healthy subjects (77% +/- 41) (P < 0.05), which indicates increased beta-receptor response to noradrenaline in CH patients in remission.
Positive_regulation (increased) of beta-receptor associated with cluster headache and noradrenaline
11) Confidence 0.41 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16776698 Disease Relevance 0.74 Pain Relevance 0.80
Similarly, opioid agonists added at the beginning of ISO exposure in DMI-pretreated cells, inhibited ISO-induced beta-receptor tachyphylaxis.
Positive_regulation (induced) of beta-receptor associated with mu agonist
12) Confidence 0.40 Published 1987 Journal Brain Res. Section Abstract Doc Link 2823987 Disease Relevance 0.14 Pain Relevance 0.58
In addition, the basal cAMP level was measured as well as the cAMP-accumulation after stimulation of the adenylcyclase (AC) via the beta-receptor with 10(-4) M isoprenaline (IPN) and after direct stimulation of AC with 10(-4) M forskolin.
Positive_regulation (stimulation) of beta-receptor associated with ipn
13) Confidence 0.40 Published 1990 Journal Klin Padiatr Section Abstract Doc Link 2157918 Disease Relevance 0.57 Pain Relevance 0.23
Reserpine (0.25 mg/kg s.c. per day for 3 weeks) causes 25 and 46% increases in the numbers of (+/-)-3H-epinephrine and 3H-WB-4101 alpha-receptor binding sites respectively, and a 51% increase in the number of 3H-dihydroalprenolol beta-receptor sites, in rat forebrain.
Positive_regulation (increase) of beta-receptor in forebrain
14) Confidence 0.35 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 212279 Disease Relevance 0 Pain Relevance 0.26
Beta adrenoceptor numbers in hippocampus and cortex, but not in hypothalamus, were significantly increased after DSP-4.
Positive_regulation (increased) of Beta adrenoceptor in hypothalamus associated with hippocampus
15) Confidence 0.35 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 7505893 Disease Relevance 0 Pain Relevance 0.55
OPRs are typical Gi/Go-coupled receptors and activated by opioid peptides derived from the endorphin, dynorphin and enkephalin families, whereas beta-AR stimulated by catecholamines is the model system for Gs-coupled receptors.
Positive_regulation (stimulated) of beta-AR associated with dynorphin, catecholamine, enkephalin and opioid
16) Confidence 0.24 Published 2004 Journal Cardiovasc. Res. Section Abstract Doc Link 15276466 Disease Relevance 0.18 Pain Relevance 0.67
Both alpha 1- and beta-receptor binding sites were reduced in number by 25-28% in the cerebellum of dorsal bundle-lesioned rats, whereas intraventricular administration of 6-hydroxydopamine to adult rats, which depletes norepinephrine in the cerebellum by 96%, increased cerebellar alpha 1- and beta-receptor binding by 33-40%.
Positive_regulation (increased) of beta-receptor in dorsal
17) Confidence 0.21 Published 1980 Journal Brain Res. Section Abstract Doc Link 6244065 Disease Relevance 0.09 Pain Relevance 0.26
These changes have been attributed to increased beta receptor numbers in hyperthyroidism, resulting in adrenergic supersensitivity.
Positive_regulation (increased) of beta receptor associated with thyroid disease
18) Confidence 0.13 Published 1985 Journal Med. Hypotheses Section Abstract Doc Link 2985942 Disease Relevance 0.60 Pain Relevance 0.28
Varicella-zoster virus isolates, but not the vaccine strain OKA, induce sensitivity to alpha-1 and beta-1 adrenergic stimulation of sensory neurones in culture.
Positive_regulation (induce) of beta-1 associated with herpes zoster and sprains and strains
19) Confidence 0.12 Published 2003 Journal J. Med. Virol. Section Title Doc Link 12627494 Disease Relevance 1.40 Pain Relevance 0.49
In contrast, beta receptor or adenylate cyclase activation increased the rate of spontaneous discharges.
Positive_regulation (activation) of beta receptor
20) Confidence 0.12 Published 1995 Journal Epilepsy Res. Section Abstract Doc Link 7750509 Disease Relevance 0 Pain Relevance 0.33

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