INT95049

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.64
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
spinal 2
lung 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
tolerance 9 100.00 Very High Very High Very High
Antihyperalgesic 1 99.36 Very High Very High Very High
Inflammation 12 98.92 Very High Very High Very High
Analgesic 6 98.44 Very High Very High Very High
Calcitonin gene-related peptide 7 97.56 Very High Very High Very High
Antinociceptive 2 91.32 High High
ischemia 6 88.52 High High
Spinal cord 1 88.44 High High
anesthesia 2 82.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 11 98.92 Very High Very High Very High
Multiple Organ Failure 1 96.56 Very High Very High Very High
Necrosis 4 90.44 High High
Cancer 4 90.08 High High
Cv Unclassified Under Development 4 88.52 High High
Hyperalgesia 1 75.00 Quite High
Pain 3 67.52 Quite High
Injury 4 66.24 Quite High
Cv General 4 Under Development 2 62.52 Quite High
Fibrosis 1 56.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we investigated whether different analgesic drugs orally administered at antihyperalgesic doses were able to prevent the changes in PGE2 and TNF-alpha spinal levels associated with hindpaw inflammation.
Spec (whether) Negative_regulation (prevent) of Regulation (changes) of TNF-alpha in spinal associated with antihyperalgesic, inflammation and analgesic
1) Confidence 0.42 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17377112 Disease Relevance 0.58 Pain Relevance 0.39
CONCLUSION: Overall, these data show the pronounced antinociceptive effects of TNFalpha neutralization, thus suggesting that reduction of the effects of TNFalpha on pain fibers themselves significantly contributes to pain relief.


Negative_regulation (reduction) of Regulation (effects) of TNFalpha
2) Confidence 0.40 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18668541 Disease Relevance 0 Pain Relevance 0
Infusion of SNAP exerted a differential effect on TNFalpha mRNA: diminished its accumulation in the lymph node, enhanced it in the lung, and had no effect in the spleen.
Negative_regulation (diminished) of Regulation (effect) of TNFalpha in lung
3) Confidence 0.38 Published 2001 Journal Shock Section Abstract Doc Link 11303732 Disease Relevance 0.47 Pain Relevance 0.34
Interestingly, the inhibition of the ERK pathway suppressed the development of tolerance and morphine-induced up-regulation of IL-1beta, TNF-alpha, and mPGES-1.
Negative_regulation (suppressed) of Regulation (regulation) of TNF-alpha associated with tolerance and morphine
4) Confidence 0.21 Published 2009 Journal FASEB J. Section Abstract Doc Link 19299480 Disease Relevance 0.07 Pain Relevance 1.80
Furthermore, the synergistic effect of TNF-alpha and PGE(2) was abolished by inhibition of PKA but not of PKC.
Neg (not) Negative_regulation (abolished) of Regulation (effect) of TNF-alpha
5) Confidence 0.16 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17916652 Disease Relevance 0.53 Pain Relevance 0.32

General Comments

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