INT95056

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Context Info
Confidence 0.52
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.84
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppard) lipid binding (Ppard) cell proliferation (Ppard)
nucleus (Ppard) DNA binding (Ppard) lipid metabolic process (Ppard)
Anatomy Link Frequency
RMIC 2
bowel 2
Ppard (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 45 99.60 Very High Very High Very High
cOX1 3 98.96 Very High Very High Very High
COX2 10 97.20 Very High Very High Very High
aspirin 13 92.96 High High
Inflammation 12 75.00 Quite High
Analgesic 1 71.12 Quite High
agonist 9 59.28 Quite High
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 10 99.86 Very High Very High Very High
Lung Cancer 1 99.12 Very High Very High Very High
Cancer 57 98.40 Very High Very High Very High
Death 12 97.08 Very High Very High Very High
Adenoma 7 95.68 Very High Very High Very High
Intestinal Cancer 8 92.36 High High
INFLAMMATION 20 90.64 High High
Stress 4 89.00 High High
Apoptosis 23 81.20 Quite High
Colon Cancer 22 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of PPARdelta by adenoviral transfer rescued 14-3-3epsilon proteins from elimination by sulindac or indomethacin.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PPARdelta
1) Confidence 0.52 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.78 Pain Relevance 0.46
The striking distal predilection of nabumetone may be, at least partially, explained by distal bowel over-expression of COX-2 and PPAR-delta.
Positive_regulation (over-expression) of Gene_expression (over-expression) of PPAR-delta in bowel
2) Confidence 0.47 Published 2001 Journal Int. J. Cancer Section Abstract Doc Link 11304699 Disease Relevance 0.30 Pain Relevance 0.12
alleles of Ppard had enhanced growth
Positive_regulation (enhanced) of Gene_expression (alleles) of Ppard
3) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 1.13 Pain Relevance 0.03
We found that EOC cells express high levels of PPARdelta, and neutralizing PPARdelta function reduces tumor growth in vivo.
Positive_regulation (levels) of Gene_expression (express) of PPARdelta associated with cancer and ovarian cancer
4) Confidence 0.41 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17545608 Disease Relevance 1.09 Pain Relevance 0.32
Overexpression of PPARdelta using an adenovirus not only drove DRE activity but also prevented RMIC death due to COX2 inhibition.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PPARdelta in RMIC associated with cox2 and death
5) Confidence 0.30 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11927585 Disease Relevance 0.54 Pain Relevance 0.66

General Comments

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