INT95068

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Context Info
Confidence 0.03
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 4.54
Pain Relevance 5.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, IL1B) aging (IL1B) intracellular (Tlr4)
cell-cell signaling (IL1B) cytoplasm (Tlr4) cytosol (IL1B)
Anatomy Link Frequency
liver 1
cerebral cortex 1
adipose tissue 1
spleen 1
hippocampus 1
Tlr4 (Mus musculus)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 100.00 Very High Very High Very High
Inflammation 24 100.00 Very High Very High Very High
cerebral cortex 12 98.56 Very High Very High Very High
Hippocampus 12 97.40 Very High Very High Very High
Opioid 6 90.92 High High
Neuropeptide 18 89.48 High High
antagonist 24 83.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 24 100.00 Very High Very High Very High
Obesity 12 96.12 Very High Very High Very High
Necrosis 6 73.12 Quite High
Cancer 6 72.76 Quite High
Bacterial Infection 6 61.72 Quite High
Neurologic Manifestations 6 60.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripherally administered LPS up-regulated pro-inflammatory cytokine (IL-1beta and/or TNF-alpha) mRNAs within the cerebral cortex, cerebellum, hippocampus, spleen, liver, and adipose tissue.
LPS Positive_regulation (up-regulated) of IL-1beta in liver associated with inflammation, obesity, hippocampus, cerebral cortex and cytokine
1) Confidence 0.03 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11306198 Disease Relevance 0.76 Pain Relevance 0.93
Peripherally administered LPS up-regulated pro-inflammatory cytokine (IL-1beta and/or TNF-alpha) mRNAs within the cerebral cortex, cerebellum, hippocampus, spleen, liver, and adipose tissue.
LPS Positive_regulation (up-regulated) of IL-1beta in spleen associated with inflammation, obesity, hippocampus, cerebral cortex and cytokine
2) Confidence 0.01 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11306198 Disease Relevance 0.76 Pain Relevance 0.93
Peripherally administered LPS up-regulated pro-inflammatory cytokine (IL-1beta and/or TNF-alpha) mRNAs within the cerebral cortex, cerebellum, hippocampus, spleen, liver, and adipose tissue.
LPS Positive_regulation (up-regulated) of IL-1beta in cerebral cortex associated with inflammation, obesity, hippocampus, cerebral cortex and cytokine
3) Confidence 0.01 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11306198 Disease Relevance 0.76 Pain Relevance 0.93
Peripherally administered LPS up-regulated pro-inflammatory cytokine (IL-1beta and/or TNF-alpha) mRNAs within the cerebral cortex, cerebellum, hippocampus, spleen, liver, and adipose tissue.
LPS Positive_regulation (up-regulated) of IL-1beta in adipose tissue associated with inflammation, obesity, hippocampus, cerebral cortex and cytokine
4) Confidence 0.01 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11306198 Disease Relevance 0.76 Pain Relevance 0.93
Peripherally administered LPS up-regulated pro-inflammatory cytokine (IL-1beta and/or TNF-alpha) mRNAs within the cerebral cortex, cerebellum, hippocampus, spleen, liver, and adipose tissue.
LPS Positive_regulation (up-regulated) of IL-1beta in cerebellum associated with inflammation, obesity, hippocampus, cerebral cortex and cytokine
5) Confidence 0.01 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11306198 Disease Relevance 0.76 Pain Relevance 0.93
Peripherally administered LPS up-regulated pro-inflammatory cytokine (IL-1beta and/or TNF-alpha) mRNAs within the cerebral cortex, cerebellum, hippocampus, spleen, liver, and adipose tissue.
LPS Positive_regulation (up-regulated) of IL-1beta in hippocampus associated with inflammation, obesity, hippocampus, cerebral cortex and cytokine
6) Confidence 0.01 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11306198 Disease Relevance 0.76 Pain Relevance 0.93

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