INT95100

Context Info Confidence 0.45 First Reported 2001 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.57 Pain Relevance 0.39

transmembrane transporter activity (SLC22A8) plasma membrane (SLC22A8) transmembrane transport (SLC22A8)

Anatomy Link Frequency brain 1 skeletal muscle 1 kidney 1 SLC22A8 (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 1 98.88 methotrexate 5 84.48 vincristine 1 82.08 cINOD 4 66.56 aspirin 1 63.20 Bile 4 46.52 Morphine 5 5.00 Patient controlled alalgesia 2 5.00 Codeine 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 1 98.88 Injury 92 98.64 INFLAMMATION 6 65.12 Chronic Renal Failure 8 5.00 Critical Illness 7 5.00 Renal Disease 6 5.00 Uremia 4 5.00 Disease 3 5.00 Hypoxia 2 5.00 Liver Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Northern blot analysis revealed that hOAT3 mRNA is expressed in the kidney, brain, and skeletal muscle.

Transcription (expressed) of hOAT3 in brain

1) Confidence 0.45 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11306713 Disease Relevance 0 Pain Relevance 0.04

Northern blot analysis revealed that hOAT3 mRNA is expressed in the kidney, brain, and skeletal muscle.

Transcription (expressed) of hOAT3 in kidney

2) Confidence 0.15 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11306713 Disease Relevance 0 Pain Relevance 0.04

Northern blot analysis revealed that hOAT3 mRNA is expressed in the kidney, brain, and skeletal muscle.

Transcription (expressed) of hOAT3 in skeletal muscle

3) Confidence 0.15 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11306713 Disease Relevance 0 Pain Relevance 0.04

Induction of AKI in ischemia-reperfusion rat models demonstrates decreased OAT1 and OAT3 mRNA as well as protein expression [34-36].

Transcription (expression) of OAT3 associated with ischemia and injury

4) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.57 Pain Relevance 0.26

General Comments

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