INT95105

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 16.36
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TGFBR2)
Anatomy Link Frequency
blood vessels 2
urinary bladder 1
skin 1
lung 1
TGFBR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 100.00 Very High Very High Very High
Neuropeptide 2 99.00 Very High Very High Very High
opiate 12 98.52 Very High Very High Very High
agonist 8 97.16 Very High Very High Very High
pain pelvic 1 95.32 Very High Very High Very High
Dysuria 1 94.80 High High
Opioid 7 94.32 High High
Inflammatory response 4 92.72 High High
Pain 7 92.08 High High
psoriasis 2 84.80 Quite High
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 230 100.00 Very High Very High Very High
Prostate Cancer 90 100.00 Very High Very High Very High
Targeted Disruption 5 100.00 Very High Very High Very High
Squamous Cell Carcinoma 305 99.92 Very High Very High Very High
Adenocarcinoma 311 99.60 Very High Very High Very High
Cancer 268 99.42 Very High Very High Very High
Apoptosis 49 99.40 Very High Very High Very High
Injury 25 99.26 Very High Very High Very High
Disease 92 96.92 Very High Very High Very High
Wound Healing 6 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally beta-endorphin upregulates the expression of transforming growth factor beta type II receptor in human skin organ cultures.
Gene_expression (expression) of transforming growth factor beta type II receptor in skin
1) Confidence 0.64 Published 2003 Journal J. Invest. Dermatol. Section Abstract Doc Link 12535211 Disease Relevance 1.08 Pain Relevance 1.07
Different expression of mu-opiate receptor in chronic and acute wounds and the effect of beta-endorphin on transforming growth factor beta type II receptor and cytokeratin 16 expression.
Gene_expression (expression) of transforming growth factor beta type II receptor associated with injury and opiate
2) Confidence 0.64 Published 2003 Journal J. Invest. Dermatol. Section Title Doc Link 12535211 Disease Relevance 0.82 Pain Relevance 0.81
In tumours where 4/5 of the CIMP panel were hypermethylated, they found a decrease in the expression of nuclear p27 and p53, as well as reduced expression of COX2 and increased TGFBR2 mutations.
Gene_expression (expression) of TGFBR2 associated with cancer and cox2
3) Confidence 0.52 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.62 Pain Relevance 0.05
Expression of BMP7, TGFBR2, and FOS was collectively compared in all datasets except for the Database 5 that had only SCC available.
Gene_expression (Expression) of TGFBR2 associated with squamous cell carcinoma
4) Confidence 0.50 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.04 Pain Relevance 0
These results support that both AD and SCC subtypes have suppressed TGF-beta signaling but through different mechanisms: in SCC there is increased expression of BMP7 that antagonizes TGF-beta functions [39], and reduced expression of TGFBR2, which suggests that SCC might be more sensitive than AD to targeting BMP7 or increasing expression of TGFBR2.
Gene_expression (expression) of TGFBR2 associated with squamous cell carcinoma and adenocarcinoma
5) Confidence 0.50 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.07 Pain Relevance 0
These results support that both AD and SCC subtypes have suppressed TGF-beta signaling but through different mechanisms: in SCC there is increased expression of BMP7 that antagonizes TGF-beta functions [39], and reduced expression of TGFBR2, which suggests that SCC might be more sensitive than AD to targeting BMP7 or increasing expression of TGFBR2.
Gene_expression (expression) of TGFBR2 associated with squamous cell carcinoma and adenocarcinoma
6) Confidence 0.50 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.03 Pain Relevance 0
Those expressed extracellularly and with an average expression level at least three-fold greater in BPH RNA pools than in the prostate cancer RNA pools included: CDH13, CHRNB1, COL4A5, EFEMP2, EMP3, F10 (16-fold), FGF2, FGFBP1 (10-fold), IGF1, IGF2 (18-fold), LIPG, RARB, SGCA, SGCD, TGFB1, TGFB3 (14-fold), TGFBR2 and TIMP2 of the “high in BPH, moderate in prostate cancer” group; SMOC1 (26-fold) in the “high in BPH, low in prostate cancer” group; and SCGB3A1 (15-fold) and SCGB1A1 (14-fold) in the “moderate in BPH, low in prostate cancer” group.


Gene_expression (expressed) of TGFBR2 associated with benign prostatic hypertrophy and prostate cancer
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 2.55 Pain Relevance 0
However, expression of TGFbetaRII, FGFR3 and IGFRI, but not BMP RII, were observed in the ingrowing blood vessels that characterize part of the disease aetiology.
Gene_expression (expression) of TGFbetaRII in blood vessels associated with disease
8) Confidence 0.44 Published 2005 Journal J. Pathol. Section Abstract Doc Link 16278806 Disease Relevance 0.22 Pain Relevance 0.09
However, expression of TGFbetaRII, FGFR3 and IGFRI, but not BMP RII, were observed in the ingrowing blood vessels that characterize part of the disease aetiology.
Gene_expression (expression) of BMP RII in blood vessels associated with disease
9) Confidence 0.44 Published 2005 Journal J. Pathol. Section Abstract Doc Link 16278806 Disease Relevance 0.22 Pain Relevance 0.09
Expression of the other two genes, FOS and TGFBR2, is reduced in tumor tissues, which is in agreement with the literature [26-28].
Gene_expression (Expression) of TGFBR2 associated with cancer
10) Confidence 0.43 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.37 Pain Relevance 0
This immunohistochemical study has for the first time investigated the expression and localization of four potentially beneficial growth factor receptors (i.e.
Gene_expression (expression) of TGFbetaRII
11) Confidence 0.38 Published 2005 Journal J. Pathol. Section Abstract Doc Link 16278806 Disease Relevance 0.36 Pain Relevance 0.26
Firstly, estrogen increased expression of the anti-apoptotic PCP4 gene and suppressed the expression of growth inhibitory receptors PTGER3 and TGFBR2.
Gene_expression (expression) of TGFBR2 associated with apoptosis
12) Confidence 0.28 Published 2007 Journal BMC Womens Health Section Abstract Doc Link PMC1852551 Disease Relevance 0.60 Pain Relevance 0
These are EMP3, FGF2, FGFBP1, IGF1, IGF2, TGFB3, TGFBR2, and TIMP2.
Gene_expression (These) of TGFBR2
13) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 1.72 Pain Relevance 0.03
Among the 11 datasets, majority of them show that BMP7 is up-regulated and TGFBR2/FOS are down-regulated in both AD and SCC compared to normal lung, whereas between AD and SCC, BMP7 has an opposite expression pattern to TGFBR2/FOS (Figure 5).
Gene_expression (expression) of TGFBR2 in lung associated with squamous cell carcinoma and adenocarcinoma
14) Confidence 0.19 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.09 Pain Relevance 0
Solitary fibrous tumour of the urinary bladder with expression of bcl-2, CD34, and insulin-like growth factor type II.
Gene_expression (expression) of factor type II in urinary bladder associated with cancer
15) Confidence 0.16 Published 2001 Journal Eur. Urol. Section Title Doc Link 11306891 Disease Relevance 0.71 Pain Relevance 0.19
RII) or transgenic disruption of the IL-2 receptor alpha that is highly expressed on Tregs was performed [198, 199].
Gene_expression (expressed) of RII associated with targeted disruption
16) Confidence 0.02 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.85 Pain Relevance 0.16

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