INT95117

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Context Info
Confidence 0.71
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 71
Total Number 71
Disease Relevance 51.17
Pain Relevance 6.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
Anatomy Link Frequency
platelet 8
fibroblasts 2
ECM 2
stem 2
Epithelial cells 2
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 502 99.68 Very High Very High Very High
rheumatoid arthritis 245 99.68 Very High Very High Very High
Pain 107 99.64 Very High Very High Very High
cINOD 36 99.36 Very High Very High Very High
metalloproteinase 109 99.24 Very High Very High Very High
Inflammation 1074 98.14 Very High Very High Very High
fibrosis 243 96.48 Very High Very High Very High
COX-2 inhibitor 12 95.84 Very High Very High Very High
Chronic pancreatitis 33 93.48 High High
Inflammatory marker 18 92.04 High High
Disease Link Frequency Relevance Heat
Cancer 945 99.86 Very High Very High Very High
Malignant Neoplastic Disease 48 99.84 Very High Very High Very High
Disease 402 99.82 Very High Very High Very High
Hodgkin's Disease 6 99.78 Very High Very High Very High
Ovarian Cancer 512 99.76 Very High Very High Very High
Solid Tumor 84 99.72 Very High Very High Very High
Injury 760 99.68 Very High Very High Very High
Rheumatoid Arthritis 364 99.68 Very High Very High Very High
Anaemia 22 99.68 Very High Very High Very High
Pain 97 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Savikko et al demonstrated that cyclosporin A treatment cannot inhibit the expression of PDGF ligands and receptors, although it ameliorated the extent of inflammation [28].
Gene_expression (expression) of PDGF associated with inflammation
1) Confidence 0.71 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.88 Pain Relevance 0.49
Epithelial cells do not express PDGF and PDGFR under physiological conditions.
Neg (not) Gene_expression (express) of PDGF in Epithelial cells
2) Confidence 0.71 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.83 Pain Relevance 0.40
Continued stimulation of these cells after their arrival to the wound leads to endogenous production of PDGF, provisional ECM synthesis, fibroblast proliferation, and collagen production.
Gene_expression (production) of PDGF in ECM associated with injury
3) Confidence 0.71 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 0.76 Pain Relevance 0
These studies stemmed from the observations that most of the cell types entering the wound are capable of synthesizing PDGF and are also activated by PDGF and the hypothesis that exogenous application of PDGF could amplify its proliferative effect through an autocrine feedback loop (Pierce et al 1991).
Gene_expression (synthesizing) of PDGF associated with injury
4) Confidence 0.71 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 1.55 Pain Relevance 0.12
We found that, in vitro, irradiation of fibroblasts and endothelium induced autocrine and paracrine PDGF expression.
Gene_expression (expression) of PDGF in endothelium
5) Confidence 0.55 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.28 Pain Relevance 0.11
Continued stimulation of these cells after their arrival to the wound leads to endogenous production of PDGF, provisional ECM synthesis, fibroblast proliferation, and collagen production.
Gene_expression (production) of PDGF in ECM associated with injury
6) Confidence 0.55 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 0.83 Pain Relevance 0
In agreement with our co-culture results, endothelial cells are described as potential sources of PDGF after radiation [6].
Gene_expression (sources) of PDGF in endothelial cells
7) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.84 Pain Relevance 0.41
De et al. reported that ASM cells in culture could also express PDGF following IL-1?
Gene_expression (express) of PDGF
8) Confidence 0.48 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.45 Pain Relevance 0.09
In multivariate analyses, higher levels of PDGF and lower levels of VEGF were associated with elevated regurgitation velocity.
Gene_expression (levels) of PDGF associated with acid reflux
9) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.58 Pain Relevance 0.05
Our observation of opposing VEGF and PDGF profiles in normal versus elevated tricuspid regurgitation velocity groups supports the idea that elevated velocity associates with known factors involved in pulmonary hypertension, and that this clinical measure may be useful for dissecting the pathogenesis of the early stages of cardiopulmonary complications of sickle cell disease.
Gene_expression (profiles) of PDGF associated with sickle cell anemia, secondary pulmonary hypertension and tricuspid valve insufficiency
10) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.39 Pain Relevance 0.03
Activated macrophages, eosinophils, epithelial cells, fibroblasts and smooth muscle cells produce PDGF.
Gene_expression (produce) of PDGF in fibroblasts
11) Confidence 0.42 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.44 Pain Relevance 0.09
De et al. reported that ASM cells in culture could also express PDGF following IL-1?
Gene_expression (express) of PDGF
12) Confidence 0.42 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.45 Pain Relevance 0.09
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Gene_expression (levels) of PDGFA
13) Confidence 0.41 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.37 Pain Relevance 0.49
Then, these unfragmented megakaryocytes stimulate the production of platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) by endothelial cells, resulting in angiogenesis and endothelial hyperplasia which is manifested as clubbing of fingers and toes [7].
Gene_expression (production) of PDGF in fingers associated with hyperplasia
14) Confidence 0.40 Published 2008 Journal Cases J Section Body Doc Link PMC2567299 Disease Relevance 1.71 Pain Relevance 0
PDGF immunoreactivity was graded in vascular channels as occupying: 0, none; 1, <50%; and 2, ?
Gene_expression (immunoreactivity) of PDGF
15) Confidence 0.39 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0 Pain Relevance 0.07
In addition, activated platelets might be a source of increased plasma PDGF levels in sickle cell disease [22].
Gene_expression (source) of PDGF in platelets associated with sickle cell anemia
16) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.17 Pain Relevance 0.09
, IL-8 and IL-10 have been localized to subchondral stromal cells both in RA and OA [21, 38], and we similarly demonstrate expression of both VEGF and PDGF.
Gene_expression (expression) of PDGF in stromal cells associated with rheumatoid arthritis
17) Confidence 0.35 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.84 Pain Relevance 0.21
PGE2 induced by COX-2 exerts several biological properties that may be advantageous for tumorigenesis: 1) Promoting angiogenesis (increased VEGF, bFGF, and PDGF production), 2) Anti-apoptosis mechanism (via increased bcl-2 and Akt activity), 3) Stimulating tumor metastasis (by increasing matrix metalloproteinases) and 4) Decreased immune surveillance (decreased cytokine production and NK activity).
Gene_expression (production) of PDGF associated with metalloproteinase, apoptosis, metastasis and cytokine
18) Confidence 0.33 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353307 Disease Relevance 0.73 Pain Relevance 0.28
PSC can also perpetuate their activation by producing autocrine mediators such as IL-6, TGFbeta, PDGF or the most recently discovered periostin [38].
Gene_expression (producing) of PDGF associated with primary sclerosing cholangitis
19) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.73 Pain Relevance 0.42
At present, recombinant PDGF is produced by DNA technology via incorporation of the gene for the ?
Gene_expression (produced) of recombinant PDGF
20) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546468 Disease Relevance 0.48 Pain Relevance 0

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