INT95118

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 5.03
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 97.52 Very High Very High Very High
Pain 4 95.84 Very High Very High Very High
fibrosis 27 92.96 High High
corticosteroid 2 91.84 High High
cINOD 1 89.36 High High
Inflammatory marker 6 8.56 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 7 100.00 Very High Very High Very High
Anaemia 2 99.68 Very High Very High Very High
Breast Cancer 98 99.20 Very High Very High Very High
Sickle Cell Anemia 63 99.16 Very High Very High Very High
Appetite Loss 1 98.96 Very High Very High Very High
Tricuspid Valve Insufficiency 51 98.92 Very High Very High Very High
Vomiting 1 98.32 Very High Very High Very High
Secondary Pulmonary Hypertension 29 98.24 Very High Very High Very High
Prostate Cancer 4 98.20 Very High Very High Very High
Asthenia 1 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Savikko et al demonstrated that cyclosporin A treatment cannot inhibit the expression of PDGF ligands and receptors, although it ameliorated the extent of inflammation [28].
Negative_regulation (inhibit) of Gene_expression (expression) of PDGF associated with inflammation
1) Confidence 0.54 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.89 Pain Relevance 0.49
Our observation of opposing VEGF and PDGF profiles in normal versus elevated tricuspid regurgitation velocity groups supports the idea that elevated velocity associates with known factors involved in pulmonary hypertension, and that this clinical measure may be useful for dissecting the pathogenesis of the early stages of cardiopulmonary complications of sickle cell disease.
Negative_regulation (opposing) of Gene_expression (profiles) of PDGF associated with sickle cell anemia, secondary pulmonary hypertension and tricuspid valve insufficiency
2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.40 Pain Relevance 0.03
Increased expression of PDGF receptors correlates with an increased risk of distant metastasis, decreased response to chemotherapy and reduced overall survival [22,23].
Negative_regulation (decreased) of Gene_expression (expression) of PDGF associated with metastasis
3) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 1.40 Pain Relevance 0
Imatinib inhibits PDGF BB dependent cell proliferation and migration
Negative_regulation (inhibits) of Gene_expression (proliferation) of PDGF
4) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.15 Pain Relevance 0
PDGF-r expression was detected in 80% of the metastases and 88% of primary prostate cancers.
Negative_regulation (detected) of Gene_expression (expression) of PDGF-r associated with prostate cancer and metastasis
5) Confidence 0.03 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11309325 Disease Relevance 1.20 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox