INT95119

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 14.86
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYCS) transport (CYCS) mitochondrion (CYCS)
small molecule metabolic process (CYCS) nucleus (CYCS)
Anatomy Link Frequency
SW480 1
HL-60 1
colon 1
MCF-7 1
brain 1
CYCS (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 12 99.42 Very High Very High Very High
cocaine 16 94.96 High High
ischemia 1 92.52 High High
cINOD 28 92.24 High High
cytokine 4 90.64 High High
imagery 2 89.88 High High
anesthesia 3 88.56 High High
COX-2 inhibitor 3 86.96 High High
local anesthetic 3 76.00 Quite High
Restless leg syndrome 1 76.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 124 99.84 Very High Very High Very High
Colon Cancer 25 99.36 Very High Very High Very High
Death 19 98.80 Very High Very High Very High
Brain Injury 7 98.80 Very High Very High Very High
Necrosis 3 94.76 High High
Shock 2 94.32 High High
Cancer 26 93.32 High High
Injury 5 93.04 High High
Stress 6 92.84 High High
Parkinson's Disease 1 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Akt also blocks cytochrome C release from the mitochondria through the regulation of Bcl-2 [31] and regulates expression of cIAP-1 [32].
Localization (release) of cytochrome C
1) Confidence 0.78 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 1.06 Pain Relevance 0.17
CONCLUSION: One of the pathways involved in SC-236-induced apoptosis in gastric cancer cells is through downregulation of Akt and then release of cytochrome c.


Localization (release) of cytochrome c
2) Confidence 0.78 Published 2006 Journal Digestion Section Body Doc Link 16641552 Disease Relevance 0.12 Pain Relevance 0
SC236-induced apoptosis was coupled with release of cytochrome c and activation of caspases.
Localization (release) of cytochrome c
3) Confidence 0.78 Published 2006 Journal Digestion Section Body Doc Link 16641552 Disease Relevance 0.14 Pain Relevance 0
In intact cells viz., V79 Chinese Hamster lung fibroblast, piroxicam is capable of releasing cytochrome c from mitochondria into the cytosol in a dose dependent manner along with the enhancement of downstream proapoptotic event viz., increase in caspase-3 activity.
Localization (releasing) of cytochrome c in fibroblast
4) Confidence 0.78 Published 2007 Journal Biochim. Biophys. Acta Section Abstract Doc Link 17306218 Disease Relevance 0.23 Pain Relevance 0.19
Incomplete scavenging of ROS and RNS particularly affects the mitochondrial lipid cardiolipin (CL), triggers the release of mitochondrial cytochrome c, and activates the intrinsic death pathway.
Localization (release) of cytochrome c associated with death
5) Confidence 0.78 Published 2008 Journal Acc. Chem. Res. Section Abstract Doc Link 18193822 Disease Relevance 0.63 Pain Relevance 0
Moreover, melatonin reduces indomethacin-mediated activation of caspase-9 and caspase-3 by blocking the release of cytochrome c and finally rescues gastric mucosal cells from indomethacin-induced apoptosis as measured by the TUNEL assay.
Localization (release) of cytochrome c associated with apoptosis
6) Confidence 0.78 Published 2009 Journal J. Pineal Res. Section Abstract Doc Link 19220725 Disease Relevance 0.96 Pain Relevance 0.40
CMZ induced mitochondrial damage by increasing the levels of intracellular calcium, lowering the mitochondrial membrane potential, and thereby inducing cytochrome c release.
Localization (release) of cytochrome c
7) Confidence 0.78 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19497364 Disease Relevance 0.76 Pain Relevance 0.07
Release of cytochrome c from mitochondria, activation of caspase-3, and condensed nuclear chromatin were evident 6 h after capsaicin exposure, but cytotoxicity was unaffected by a pan-caspase inhibitor (zVAD-fmk, 50 microM).
Localization (Release) of cytochrome c
8) Confidence 0.78 Published 2010 Journal Br J Anaesth Section Body Doc Link 20354008 Disease Relevance 0 Pain Relevance 0
Upon FR122047 treatment, there were apparent increases in the ratio of Bax to Bcl-2, mitochondrial cytochrome c release, and apoptosis in MCF-7 cells.
Localization (release) of cytochrome c in MCF-7 associated with apoptosis
9) Confidence 0.78 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.89 Pain Relevance 0.26
Increase in cyclic AMP and decrease in TNF-alpha levels were identified in the ipsilateral cortex under treatment with cilostazol accompanied by decreased Bax formation and cytochrome c release with increased Bcl-2 production in the penumbral area as well as in the in vitro human umbilical endothelial cells.
Localization (release) of cytochrome c in endothelial cells
10) Confidence 0.78 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.62 Pain Relevance 0.12
We identified a potential role for BAX recruitment to the mitochondria, secondary to cytoplasmic translocation of TR3, in inducing cytochrome c release and in mediating apoptosis.
Localization (release) of cytochrome c associated with apoptosis
11) Confidence 0.78 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14500374 Disease Relevance 0.93 Pain Relevance 0.08
However, the rate of cytochrome c release was higher in Q204L-overexpressing cells than in HT-29 cells.
Localization (release) of cytochrome c in HT-29
12) Confidence 0.78 Published 2001 Journal Exp. Cell Res. Section Abstract Doc Link 11478840 Disease Relevance 0.48 Pain Relevance 0.08
However, bupivacaine did not induce either mitochondrial permeability transition (PT) or release of cytochrome c in experiments with isolated mitochondria.
Localization (release) of cytochrome c
13) Confidence 0.78 Published 2003 Journal J Toxicol Sci Section Abstract Doc Link 12820540 Disease Relevance 0.77 Pain Relevance 0.08
A mutant TR3 construct lacking DNA-binding ability exerted a potent proapoptotic effect in colon cancer cells that was associated with cytochrome c release, an action dependent upon cytoplasmic localization of the construct, but, again, not its direct mitochondrial targeting.
Localization (release) of cytochrome c in colon associated with colon cancer
14) Confidence 0.78 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14500374 Disease Relevance 0.95 Pain Relevance 0.09
Conversely, a major increase in cytochrome c release, caspase 3-dependent apoptosis, and decreased metabolic neuronal viability were observed upon sequential exposure to Her and Coc.
Localization (release) of cytochrome c in neuronal associated with apoptosis and cocaine
15) Confidence 0.73 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.80 Pain Relevance 0.69
Cytochrome c release and caspase activation after traumatic brain injury.
Localization (release) of Cytochrome c in brain associated with brain injury
16) Confidence 0.68 Published 2002 Journal Brain Res. Section Title Doc Link 12213303 Disease Relevance 1.18 Pain Relevance 0.09
Ectopic Bcl-2 attenuated cytochrome c release and apoptosis induction compared with SW480/neo cells.
Localization (release) of cytochrome c in SW480 associated with apoptosis
17) Confidence 0.68 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227396 Disease Relevance 1.26 Pain Relevance 0.16
The authors evaluated cell viability, mitochondrial alterations, cytochrome c release, caspase activation, and early apoptosis.
Localization (release) of cytochrome c
18) Confidence 0.68 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.09 Pain Relevance 0
At low concentrations (3-6 mm) of lidocaine, caspase 3 was activated and release of cytochrome c was detected, whereas at higher concentrations (10 mm), no caspase activation was found.
Localization (release) of cytochrome c
19) Confidence 0.68 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.07 Pain Relevance 0
TR3 induces apoptosis in a number of cell lineages exposed to proapoptotic stimuli by directly targeting the mitochondria, inducing cytochrome c release.
Localization (release) of cytochrome c associated with apoptosis
20) Confidence 0.68 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14500374 Disease Relevance 0.74 Pain Relevance 0.07

General Comments

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