INT95120

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 76
Total Number 77
Disease Relevance 67.55
Pain Relevance 5.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9) peptidase activity (CASP9) nucleus (CASP9)
intracellular (CASP9)
Anatomy Link Frequency
cleavage 6
SiHa 2
macrophages 1
hepatocytes 1
colon 1
CASP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 25 99.98 Very High Very High Very High
Inflammation 317 97.36 Very High Very High Very High
cytokine 169 96.20 Very High Very High Very High
medulla 22 94.72 High High
ischemia 30 93.76 High High
antagonist 100 93.60 High High
Spinal cord 34 93.60 High High
cINOD 118 89.72 High High
aspirin 48 85.52 High High
palliative 15 82.00 Quite High
Disease Link Frequency Relevance Heat
Death 1014 99.68 Very High Very High Very High
Apoptosis 3698 99.64 Very High Very High Very High
Cancer 1899 99.64 Very High Very High Very High
Stress 361 99.60 Very High Very High Very High
Pancreatic Cancer 95 99.32 Very High Very High Very High
Colon Cancer 213 99.16 Very High Very High Very High
Parkinson's Disease 54 99.16 Very High Very High Very High
Disorder Of Lipid Metabolism 314 99.12 Very High Very High Very High
Reprotox - General 1 183 98.70 Very High Very High Very High
Hypothermia 138 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytosolic CytC is required for the formation of the apoptosome and the resulting activation of procaspase-9 which in turn cleaves and activates the downstream effecter caspase-3 which then leads to eventual cell apoptosis [32, 33].
Positive_regulation (activation) of caspase-9 associated with apoptosis
1) Confidence 0.67 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.74 Pain Relevance 0
Fluorometric assay showed that codeinone time-dependently activated caspase 3 and caspase 9, but not caspase 8, suggesting the activation of intrinsic apoptotic signaling pathway via mitochondria.
Positive_regulation (activated) of caspase 9 associated with apoptosis
2) Confidence 0.67 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894543 Disease Relevance 1.01 Pain Relevance 0.26
HDL has been implicated in curtailing the apoptosis and promoting the proliferation and migration of endothelial cells especially when damaged through the inhibition of the activation of caspase- 3 and caspase-9.
Positive_regulation (activation) of caspase-9 in endothelial cells associated with apoptosis and disorder of lipid metabolism
3) Confidence 0.67 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.26 Pain Relevance 0
There, cytochrome c forms a complex with Apaf-1, leading to activation of caspase-9 that, in turn, activates executioner caspases such as caspase-3, -6, and -7, which are instrumental in the induction of apoptosis (19, 24).
Positive_regulation (activation) of caspase-9 associated with apoptosis
4) Confidence 0.67 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.08 Pain Relevance 0
Derivatives induced apoptosis was mediated by the cleavage and activation of caspase-9 and caspase-3, but not caspase 8, implicating the mitochondrial pathway for apoptosis induction.
Positive_regulation (activation) of caspase-9 in cleavage associated with apoptosis
5) Confidence 0.55 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.32 Pain Relevance 0.12
Our results support this notion where both procaspase-9 and the active caspase-9 were significantly increased in the Pa-PDT treated R-HepG2 cells, and finally trigger the activation of procaspase-3 that was started to be cleaved at 2 h after the Pa-PDT treatment (Figure 5A).
Positive_regulation (increased) of caspase-9
6) Confidence 0.49 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.71 Pain Relevance 0
Moderate hypothermia has been shown to suppress Fas-mediated apoptosis in stored cultured hepatocytes, along with suppression of cytochrome-c release from mitochondria and downstream activation of caspase-7 and caspase-9 [103].
Positive_regulation (activation) of caspase-9 in hepatocytes associated with hypothermia and apoptosis
7) Confidence 0.45 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 2.07 Pain Relevance 0.22
Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.
Positive_regulation (induced) of caspase-9 in cleavage associated with qutenza
8) Confidence 0.37 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.09 Pain Relevance 0.76
In three selected colon cancer cell lines, NS398-induced apoptosis was mediated by the release of cytochrome c from mitochondria and, consequently, by the activation of caspase-9 and caspase-3 and by the cleavage of poly(ADP-ribose) polymerase.
Positive_regulation (activation) of caspase-9 in cleavage associated with colon cancer and apoptosis
9) Confidence 0.37 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11309352 Disease Relevance 1.24 Pain Relevance 0.15
The intrinsic pathway is triggered by mitochondrial death signals, which lead to the activation of caspase-9.
Positive_regulation (activation) of caspase-9 associated with death
10) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.87 Pain Relevance 0.12
Following caspase-9 activation, Pro-caspase-3 expression was downregulated significantly.
Positive_regulation (activation) of caspase-9
11) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.76 Pain Relevance 0
Activated caspase-9 cleaves and activates procaspase-3 [31].
Positive_regulation (Activated) of caspase-9
12) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.54 Pain Relevance 0
Western Blotting demonstrated the Bcl-2 and pro-caspase-3 were down-regulated while the Bax and caspase-9 were up-regulated.
Positive_regulation (up-regulated) of caspase-9
13) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2924280 Disease Relevance 0.76 Pain Relevance 0
It led to an increase in cytosolic Ca(2+), calpain activation, loss of the mitochondrial transmembrane potential, release of mitochondrial cytochrome c, and caspase-9 and -7 activation.
Positive_regulation (activation) of caspase-9
14) Confidence 0.25 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.17 Pain Relevance 0.78
Affymetrix microarray analysis showed that butyrate treatment increased the level of caspase-9 mRNA to a small extent (data not shown).
Positive_regulation (increased) of caspase-9 mRNA
15) Confidence 0.24 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.52 Pain Relevance 0
Valproic acid and butyrate activate both the caspase-8 and caspase-9
Positive_regulation (activate) of caspase-9
16) Confidence 0.24 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.64 Pain Relevance 0
Most intriguingly, the caspase-9 activity is more robustly activated than caspase-8 upon the valproic acid or butyrate treatment (Fig. 3).
Positive_regulation (activated) of caspase-9
17) Confidence 0.24 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.94 Pain Relevance 0
As shown in Fig. 3C, valproic acid or butyrate treatment induced the caspase-9 activity and again butyrate induced activity of the caspase-9 more robustly than valproic acid, about 9 fold versus 4 fold.
Positive_regulation (induced) of caspase-9
18) Confidence 0.24 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.64 Pain Relevance 0
As shown in Fig. 3C, valproic acid or butyrate treatment induced the caspase-9 activity and again butyrate induced activity of the caspase-9 more robustly than valproic acid, about 9 fold versus 4 fold.
Positive_regulation (induced) of caspase-9
19) Confidence 0.24 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.65 Pain Relevance 0
Caspase-9 activation was quite similar in both PBS and HMW-HA treatments, except at the dose 75 mJ/cm2 of UVB, which indicated a significant caspase-9 decrease (?
Positive_regulation (activation) of Caspase-9
20) Confidence 0.23 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.20 Pain Relevance 0

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