INT95128

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.28
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNA1) transmembrane transport (KCNA1)
Anatomy Link Frequency
spike 1
digit 1
brain 1
KCNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Acupuncture 84 100.00 Very High Very High Very High
electroacupuncture 46 100.00 Very High Very High Very High
potassium channel 4 100.00 Very High Very High Very High
sodium channel 14 98.16 Very High Very High Very High
Calcium channel 2 94.00 High High
Pain 59 90.40 High High
c fibre 10 87.36 High High
antagonist 3 85.12 High High
cINOD 2 83.32 Quite High
Migraine 5 80.92 Quite High
Disease Link Frequency Relevance Heat
Ataxia 10 100.00 Very High Very High Very High
Stress 7 99.40 Very High Very High Very High
Vertigo 6 98.16 Very High Very High Very High
Chorea 3 97.16 Very High Very High Very High
Disease 10 97.14 Very High Very High Very High
Spasticity 1 96.98 Very High Very High Very High
Hypolipidemia 1 96.88 Very High Very High Very High
Cerebral Palsy 2 96.76 Very High Very High Very High
Channelopathies 2 96.76 Very High Very High Very High
Frailty 1 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conductance block was voltage dependent for Kv 3.1 but not for Kv 1.1 channels.
Neg (not) Positive_regulation (dependent) of Kv 1.1
1) Confidence 0.41 Published 2006 Journal Otol. Neurotol. Section Body Doc Link 16371858 Disease Relevance 0.06 Pain Relevance 0
Episodic ataxia type 1 (EA-1) is caused by missense mutations in the potassium channel gene KCNA1, whereas episodic ataxia type 2 (EA-2) is caused by missense and nonsense mutations in the calcium channel gene CACNA1A.
Positive_regulation (caused) of Episodic ataxia type 1 associated with ataxia, calcium channel and potassium channel
2) Confidence 0.36 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11960817 Disease Relevance 1.27 Pain Relevance 0.21
We excluded linkage to 11 regions containing genes associated with chorea and myokymia: 1) the Huntington disease gene on chromosome 4p; 2) the paroxysmal dystonic choreoathetosis gene at 2q34; 3) the dentatorubral-pallidoluysian atrophy gene at 12p13; 4) the choreoathetosis/spasticity disease locus on 1p that lies in a region containing a cluster of potassium (K+) channel genes; 5) the episodic ataxia type 1 (EA1) locus on 12p that contains the KCNA1 gene and two other voltage-gated K+ channel genes, KCNA5 and KCNA6; 6) the chorea-acanthocytosis locus on 9q21; 7) the Huntington-like syndrome on 20p; 8) the paroxysmal kinesigenic dyskinesia locus on 16p11.2-q11.2; 9) the benign hereditary chorea locus on 14q; 10) the SCA type 5 locus on chromosome 11; and 11) the chromosome 19 region that contains several ion channels and the CACNA1A gene, a brain-specific P/Q-type calcium channel gene associated with ataxia and hemiplegic migraine.
Positive_regulation (contains) of KCNA1 gene in brain associated with chorea, myoclonus, ataxia, spasticity, syndrome, migraine, calcium channel, cerebral palsy, disease, dyskinesias, huntington's chorea, hypolipidemia, frailty and dystonia
3) Confidence 0.33 Published 2001 Journal Ann. Neurol. Section Abstract Doc Link 11310626 Disease Relevance 2.34 Pain Relevance 0.16
The quail was removed from the observation box 25 min after the NP or EA stimulation started.
Positive_regulation (stimulation) of EA associated with acupuncture
4) Confidence 0.29 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397865 Disease Relevance 0 Pain Relevance 0.21
For the other body territories, the number of sites slightly increased post-lesion in Mk1 and Mk2 (suggesting replacement of a few original digit points), but decreased in Mk3.
Positive_regulation (increased) of Mk1 in digit
5) Confidence 0.23 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1224856 Disease Relevance 0 Pain Relevance 0
This postulation was supported by an earlier observation that there was a high correlation between the tingling component of the acupuncture sensation (de qi) and peripheral electrical conductance elevation with EA, suggesting an EA induced peripheral sensory fiber activation [17].
Positive_regulation (induced) of EA associated with acupuncture and electroacupuncture
6) Confidence 0.09 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2386116 Disease Relevance 0.52 Pain Relevance 1.17
The modulation of cell excitability might be explained by the activation of voltage-gated potassium channel Kv1 [36]–[41], inactivation of voltage-gated sodium channels [15], [16], [19], [21], fluctuations in sodium channel gating [42], inhibitory synaptic conductance [43]–[45] and the site of spike initiation [14].
Positive_regulation (activation) of voltage-gated potassium channel in spike associated with sodium channel and potassium channel
7) Confidence 0.01 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900290 Disease Relevance 0 Pain Relevance 0.18
To further determine the inhibitory effect of EA on Wnt signaling, the stable SuperTOPflash reporter cell line was treated with Wnt3a and increasing concentrations of EA.
Positive_regulation (increasing) of EA
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.08 Pain Relevance 0.27

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