INT95131

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 21.62
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T-cell 3
neurons 2
nervous system 2
macrophages 1
eosinophils 1
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 522 99.60 Very High Very High Very High
Chronic pancreatitis 8 99.40 Very High Very High Very High
dorsal root ganglion 420 96.92 Very High Very High Very High
Neuropathic pain 120 96.12 Very High Very High Very High
fibrosis 70 93.92 High High
Sciatic nerve 60 91.44 High High
Inflammation 55 87.28 High High
isoflurane 23 86.64 High High
Lasting pain 21 83.60 Quite High
rheumatoid arthritis 2 81.72 Quite High
Disease Link Frequency Relevance Heat
Immune Reconstitution Inflammatory Syndrome 396 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 75 100.00 Very High Very High Very High
Infection 110 99.82 Very High Very High Very High
Injury 342 99.64 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 647 99.62 Very High Very High Very High
Pancreatitis 8 99.40 Very High Very High Very High
Apoptosis 3 98.90 Very High Very High Very High
Asthma 18 98.86 Very High Very High Very High
Hypertriglyceridemia 12 97.28 Very High Very High Very High
Ganglion Cysts 420 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, such altered function may play a role in the asthmatic response, which is thought to depend primarily upon the interaction of mast cells, eosinophils, macrophages, CD4+ T cells, and IgE-producing B cells [24-26].
CD4 Binding (interaction) of in macrophages associated with asthma
1) Confidence 0.37 Published 2007 Journal Respir Res Section Body Doc Link PMC2213655 Disease Relevance 0.64 Pain Relevance 0.18
AIMS: To quantitatively determine the influence of estradiol on acinar cell apoptosis and chronic pancreatitis; assess its effects on infiltration of CD4 and CD8 T cells in the pancreas; investigate the role of testosterone on chronic pancreatitis in 20-week-old male WBN/Kob rats; and determine the impact of estradiol on proliferation of splenocytes derived from these animals in vitro.
CD4 Binding (infiltration) of in T cells associated with apoptosis and chronic pancreatitis
2) Confidence 0.35 Published 2003 Journal Pancreas Section Abstract Doc Link 12657966 Disease Relevance 0.45 Pain Relevance 0.27
CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation?


CD4 Binding (count) of associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.35 Published 2010 Journal AIDS Res Ther Section Title Doc Link PMC3022663 Disease Relevance 0.57 Pain Relevance 0
The median CD4 cell count was 151 cells/mm3 (IQR 106-190) for women who initiated HAART with a CD4 cell count ?
CD4 Binding (initiated) of
4) Confidence 0.31 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2904297 Disease Relevance 1.36 Pain Relevance 0.06
The events that lead to these effects in the nervous system may be dependent on human CD4 (hCD4) binding and conformational changes in gp120 enabling it to bind to chemokine receptors with high affinity [17].
CD4 Binding (binding) of in nervous system associated with chemokine
5) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.98 Pain Relevance 0.41
For example, patients on ART are currently monitored annually for CD4+, but a shorter interval may be required to prevent the adverse consequences of treatment failure.14
CD4 Binding (monitored) of
6) Confidence 0.26 Published 2010 Journal International Journal of Epidemiology Section Body Doc Link PMC2992619 Disease Relevance 0.68 Pain Relevance 0
The events that lead to these effects in the nervous system may be dependent on human CD4 (hCD4) binding and conformational changes in gp120 enabling it to bind to chemokine receptors with high affinity [17].
hCD4 Binding (binding) of in nervous system associated with chemokine
7) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.98 Pain Relevance 0.41
Alternatively, some of the toxic effects of gp120 may be independent of hCD4 binding and be mediated by alternative mechanisms [18,19].
hCD4 Binding (binding) of
8) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.80 Pain Relevance 0.42
l recombinant human CD4 (hCD4), a glycoprotein coreceptor for gp120 [23], reconstituted in 0.1% BSA/PBS solution (100 ?
CD4 Binding (recombinant) of
9) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.34 Pain Relevance 0.24
l recombinant human CD4 (hCD4), a glycoprotein coreceptor for gp120 [23], reconstituted in 0.1% BSA/PBS solution (100 ?
hCD4 Binding (recombinant) of
10) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.34 Pain Relevance 0.24
The combination of gp120/hCD4 and ddC treatment did not produce significant changes in the percentage of colocalized CCR2/TRPV1 immunopositive neurons when compared with rodents subjected to perineural gp120/hCD4 (46.2 ± 0.78%; Fig. 3F, G).


hCD4 Binding (perineural) of in neurons
11) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.47 Pain Relevance 0.34
To establish the degree to which CXCR4 signaling is evident in rodents subjected to perineural gp120/hCD4 alone or in combination with ddC, we first determined to what extent this chemokine receptor was altered by the same injury paradigms as discussed above.
hCD4 Binding (perineural) of associated with chemokine and injury
12) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.57 Pain Relevance 0.41
In sharp contrast, following the combination of gp120/hCD4 and ddC injury paradigm, mRNA transcripts were upregulated by POD 21 in the DRG ipsilateral to injury in virtually all neurons (Fig. 6E).


hCD4 Binding (combination) of in neurons associated with dorsal root ganglion and injury
13) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.18 Pain Relevance 0.52
It should be noted that direct gp120/hCD4 signaling via CXCR4 was not the causative effect, as AMD3100 did not alter hypernociceptive behavior in this model.
hCD4 Binding (direct) of
14) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.57 Pain Relevance 0.29
Overall, the adjusted risk of elevated triglycerides decreased with increasing HIV-1 RNA [OR (95%CI), 0.86(0.78 to 0.95) per 1 log10 increase; P = 0.002], and there was also a significant association with CD4 cell count [OR, 1.20 (IC95%: 1.10 to 1.31) per log2 CD4 twofold increase; P < 0.001].


CD4 Binding (association) of associated with hypertriglyceridemia and acquired immune deficiency syndrome or hiv infection
15) Confidence 0.19 Published 2008 Journal The Open AIDS Journal Section Body Doc Link PMC2556198 Disease Relevance 1.37 Pain Relevance 0
We found a strong association between elevated total cholesterol level and higher CD4 cell counts, which was present within each treatment category.
CD4 Binding (association) of associated with disorder of lipid metabolism
16) Confidence 0.19 Published 2008 Journal The Open AIDS Journal Section Body Doc Link PMC2556198 Disease Relevance 1.09 Pain Relevance 0
For total cholesterol, the association with HIV-1 viral load was the inverse of the association with CD4 cell count.
CD4 Binding (association) of associated with acquired immune deficiency syndrome or hiv infection and disorder of lipid metabolism
17) Confidence 0.19 Published 2008 Journal The Open AIDS Journal Section Body Doc Link PMC2556198 Disease Relevance 1.11 Pain Relevance 0
Importantly, the T-tropic HIV1 viral coat protein, gp120 IIIB, was primed with hCD4, which facilitates high affinity binding to CXCR4 chemokine receptors [17].
hCD4 Binding (binding) of associated with chemokine and acquired immune deficiency syndrome or hiv infection
18) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.92 Pain Relevance 0.37
Cox models with time-varying covariates were used to evaluate the association between IRIS diagnosis and CD4+ and CD8+ T-cell counts, CD4+ and CD8+ percentages, and HIV RNA levels prior to IRIS diagnosis.
CD4 Binding (association) of in T-cell associated with immune reconstitution inflammatory syndrome and acquired immune deficiency syndrome or hiv infection
19) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2895658 Disease Relevance 0.86 Pain Relevance 0.14
For instance, such altered function may play a role in the asthmatic response, which is thought to depend primarily upon the interaction of mast cells, eosinophils, macrophages, CD4+ T cells, and IgE-producing B cells [24-26].
CD4 Binding (interaction) of in mast cells associated with asthma
20) Confidence 0.13 Published 2007 Journal Respir Res Section Body Doc Link PMC2213655 Disease Relevance 0.64 Pain Relevance 0.18

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