INT95133

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 38
Total Number 41
Disease Relevance 44.09
Pain Relevance 7.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG)
plasma membrane (FASLG) cell-cell signaling (FASLG)
Anatomy Link Frequency
T cells 7
NK cells 3
lymph nodes 1
macrophage 1
knee joints 1
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 521 99.78 Very High Very High Very High
Morphine 18 99.62 Very High Very High Very High
tolerance 81 99.44 Very High Very High Very High
cytokine 530 99.06 Very High Very High Very High
endometriosis 198 98.32 Very High Very High Very High
Chronic pancreatitis 25 97.12 Very High Very High Very High
cINOD 27 96.08 Very High Very High Very High
metalloproteinase 57 94.16 High High
rheumatoid arthritis 82 86.72 High High
Pain 11 85.32 High High
Disease Link Frequency Relevance Heat
Breast Cancer 37 99.86 Very High Very High Very High
Apoptosis 844 99.80 Very High Very High Very High
Death 174 99.80 Very High Very High Very High
INFLAMMATION 592 99.78 Very High Very High Very High
Cancer 1868 99.76 Very High Very High Very High
Toxicity 24 99.36 Very High Very High Very High
Brain Tumor 18 99.32 Very High Very High Very High
Arthritis 104 99.14 Very High Very High Very High
Lymphatic System Cancer 104 98.92 Very High Very High Very High
Infection 431 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, combination treatment with As2O3 and sulindac increased the catalytic activity of caspase-3, -8, and -9 along with induction of Fas/FasL expression and cytosolic release of cytochrome c.
Gene_expression (expression) of FasL
1) Confidence 0.75 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685442 Disease Relevance 0.56 Pain Relevance 0.15
Many mechanisms have been proposed for the functional inactivation of tumor associated NK cells including the over-expression of Fas ligand, the loss of mRNA for granzyme B [2] and decreased CD16 and its associated zeta chain [15].
Gene_expression (over) of Fas ligand in NK cells associated with cancer
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.97 Pain Relevance 0
To elucidate molecular events in the apoptosis, protein expressions of Bcl-2, Bax, Fas, and FasL were measured by western blotting using specific antibodies in HL-60 cells.
Gene_expression (expressions) of FasL in HL-60 associated with apoptosis
3) Confidence 0.67 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644942 Disease Relevance 0.67 Pain Relevance 0.24
The level of Bcl-2 indicated down-regulation, but the Bax, Fas, and FasL expression showed up-regulation as compared with the untreated control cells.
Gene_expression (expression) of FasL
4) Confidence 0.67 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644942 Disease Relevance 0.65 Pain Relevance 0.22
In vitro, chondrogenic cells respond to the same apoptosis-inducing signals as other cells, including FasL/CD95, TNF-?
Gene_expression (/) of FasL associated with apoptosis
5) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 1.34 Pain Relevance 0.16
Finally, it may be possible to produce a modified FasL with a reduced toxicity profile.
Gene_expression (produce) of FasL associated with toxicity
6) Confidence 0.64 Published 2003 Journal Drugs Today Section Abstract Doc Link 14988748 Disease Relevance 1.31 Pain Relevance 0.10
Isolated disk cells were analyzed by flow cytometry for Fas, FasL, TRAIL, DR4 and DR5 expression.
Spec (analyzed) Gene_expression (expression) of FasL
7) Confidence 0.62 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.74 Pain Relevance 0.10
Intervertebral disks from 28 donors (age 12-70 years) suffering from scoliosis, vertebrae fracture or disk degeneration were scored histologically for degeneration and analyzed for gene expression of FasL/Fas, TRAIL/DR4, TNF-alpha/TNFR1 and caspase 8.
Spec (analyzed) Gene_expression (expression) of FasL in vertebrae associated with scoliosis
8) Confidence 0.62 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.82 Pain Relevance 0.12
Protein expression of FasL and TRAIL was assessed by immunohistology and apoptotic cell death was quantified by poly(ADP-ribose) polymerase (PARP) p85 staining.
Gene_expression (expression) of FasL in poly associated with apoptosis and death
9) Confidence 0.62 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.81 Pain Relevance 0.11
FasL and TRAIL expression was confirmed by immunohistology and PARP cleavage was significantly associated with degeneration (P=0.027).
Gene_expression (expression) of FasL in cleavage
10) Confidence 0.62 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.65 Pain Relevance 0.11
For KCNJ10 an annealing temperature of 57°C was needed while the FasL marker and CACNA1E SNP utilized a 35 cycle – 60°C annealing step without an extension step incorporated.


Gene_expression (marker) of FasL
11) Confidence 0.59 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 0 Pain Relevance 0
Expression of Fas ligand and loss of Bax were recently shown to correlate with shorter survival (Kokturk, 2005).
Gene_expression (Expression) of Fas ligand
12) Confidence 0.58 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.34 Pain Relevance 0
Many mechanisms have been proposed for the functional inactivation of tumor associated NK cells including the over-expression of Fas ligand, the loss of mRNA for granzyme B [2] and decreased CD16 and its associated zeta chain [15].
Gene_expression (-) of Fas ligand in NK cells associated with cancer
13) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.97 Pain Relevance 0
Many mechanisms have been proposed for the functional inactivation of tumor associated NK cells including the over-expression of Fas ligand, the loss of mRNA for granzyme B [2] and decreased CD16 and its associated zeta chain [15].
Gene_expression (expression) of Fas ligand in NK cells associated with cancer
14) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.97 Pain Relevance 0
The one exception was with adenoviral gene transfer of FasL, which resulted in synovial apoptosis but also an increase in neutrophil infiltration.
Gene_expression (transfer) of FasL in neutrophil associated with apoptosis
15) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.43 Pain Relevance 0.18
The extent of apoptosis observed was similar to that observed following adenoviral gene transfer of TRAIL and FasL.


Gene_expression (transfer) of FasL associated with apoptosis
16) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.91 Pain Relevance 0.05
Infection of naïve PBMC with ZEBOV in vitro strongly upregulates Fas/FasL expression on CD4 and CD8 T lymphocytes and also TNF-related apoptosis-inducing ligand (TRAIL) mRNA expression in the same cells [71].
Gene_expression (expression) of FasL in T lymphocytes associated with apoptosis and infection
17) Confidence 0.34 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 1.39 Pain Relevance 0.06
Therefore, we analyzed whether the ability of morphine to affect Th2 cytokine production was mediated by regulation of Fas, FasL, and TRAIL expression and AICD directly in purified Th cells.
Gene_expression (expression) of FasL associated with death, cytokine and morphine
18) Confidence 0.34 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.69 Pain Relevance 0.87
We applied RT-PCR and Western blotting for CD95L expression profiles, serial frozen section immunohistochemistry to detect CD95, CD95L, and HLA-DR molecules, CD3, CD4, CD11c, and S-100 protein (S100p).
Gene_expression (expression) of CD95L
19) Confidence 0.33 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11310825 Disease Relevance 0.48 Pain Relevance 0.27
We determined the expression of CD95 and CD95L in epithelia of normal and chronically inflamed pancreatic tissues.
Spec (determined) Gene_expression (expression) of CD95L
20) Confidence 0.33 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11310825 Disease Relevance 0.43 Pain Relevance 0.24

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