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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.67
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
Th17 cell 1
skin 1
exocrine cells 1
cytotoxic T lymphocytes 1
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 88 100.00 Very High Very High Very High
Inflammation 80 99.98 Very High Very High Very High
Neuritis 2 96.72 Very High Very High Very High
endometriosis 168 95.12 Very High Very High Very High
Chronic pancreatitis 5 90.32 High High
Inflammatory response 6 87.04 High High
rheumatoid arthritis 17 75.00 Quite High
fibrosis 2 69.64 Quite High
Adalimumab 73 62.00 Quite High
Pain 18 60.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 85 99.98 Very High Very High Very High
Endometriosis 224 98.84 Very High Very High Very High
Cancer 11 98.22 Very High Very High Very High
Fever 1 97.16 Very High Very High Very High
Neuritis 2 96.72 Very High Very High Very High
Mycobacterium Infection 86 94.00 High High
Obesity 2 91.20 High High
Pancreatitis 5 90.32 High High
Adhesions 17 86.20 High High
Stress 34 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a potential consequence, and possibly triggered by local release of IFNgamma, CD4-Th1 cells may cognately interact with and successfully attack exocrine cells by triggering CD95 on their target without being killed by epithelial, CD95L-mediated, counterattack.
Th1 Binding (interact) of in exocrine cells
1) Confidence 0.47 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11310825 Disease Relevance 0.45 Pain Relevance 0.33
Immunomodulation through the alteration of Th1/Th2 and CD4/CD8 ratios may be a pharmacological mechanism in the anti-rheumatic effect of low-dosage simvastatin.
Th1 Binding (alteration) of
2) Confidence 0.36 Published 2007 Journal Mod Rheumatol Section Abstract Doc Link 17929126 Disease Relevance 0.38 Pain Relevance 0.15
, a TH1 cytokine, inhibits CD36 expression via reduction of PPAR?
TH1 Binding (cytokine) of associated with cytokine
3) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.22 Pain Relevance 0.16
A clinically effective therapeutic vaccine to fight viruses or tumour requires the generation and expansion of specific cytotoxic T lymphocytes (CTL) able to proliferate and/or secrete Th1-type cytokines such as IL-2, IFN?
Th1-type Binding (proliferate) of in cytotoxic T lymphocytes associated with cancer and cytokine
4) Confidence 0.17 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.16 Pain Relevance 0.11
, IL-6, and IL21, that induce inflammatory Th1 or Th17 cell polarization, would enhance IL-4+TGF-?
Th1 Binding (polarization) of in Th17 cell associated with inflammation
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.35 Pain Relevance 0.36
In contrast, intraperitoneal injection of the Th1-like cytokine IL-12 also reduces endometriotic lesions in vivo [66], probably by enhancing cytotoxic activity.
Th1-like Binding (injection) of associated with endometriosis and cytokine
6) Confidence 0.09 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.15 Pain Relevance 0.48
We next investigated whether T1805G (I602S) might be associated with ENL or RR, a Th1-mediated immune event clinically manifested by inflamed skin lesions, fever, and neuritis.
Th1 Spec (might) Binding (associated) of in skin associated with fever and neuritis
7) Confidence 0.08 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2330092 Disease Relevance 0.96 Pain Relevance 0.10

General Comments

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