INT95135

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Context Info
Confidence 0.20
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.99
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG)
plasma membrane (FASLG) cell-cell signaling (FASLG)
Anatomy Link Frequency
lymph nodes 2
articular 2
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 28 100.00 Very High Very High Very High
Chronic pancreatitis 5 97.72 Very High Very High Very High
rheumatoid arthritis 18 86.72 High High
fibrosis 1 79.04 Quite High
Pain 1 62.16 Quite High
agonist 7 57.08 Quite High
cytokine 11 50.00 Quite Low
Arthritis 10 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 99 100.00 Very High Very High Very High
INFLAMMATION 31 100.00 Very High Very High Very High
Arthritis 25 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 42 99.48 Very High Very High Very High
Pancreatitis 5 97.72 Very High Very High Very High
Infection 101 96.88 Very High Very High Very High
Rheumatoid Arthritis 18 86.72 High High
Death 14 81.08 Quite High
Fibrosis 1 79.04 Quite High
Disease 27 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, intra-articular injection of the adenoviral (Ad)-TRAIL vector resulted in extensive apoptosis, similar to that observed with FasL, but was able to reduce joint inflammation in contrast to the inflammatory effect of FasL gene transfer.
Negative_regulation (reduce) of Gene_expression (transfer) of FasL in articular associated with inflammation, apoptosis and arthritis
1) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.35 Pain Relevance 0.26
Immunohistochemistry revealed a mutually exclusive expression of CD95 and CD95L.
Negative_regulation (revealed) of Gene_expression (expression) of CD95L
2) Confidence 0.18 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11310825 Disease Relevance 0.55 Pain Relevance 0.35
YT cells respond to CD30 signals by downregulating the expression of cytotoxic effector molecules, including FasL, thus decreasing their cytotoxicity against Fas-expressing target cells (Bowen et al, 1993; Muta et al, 2000).
Negative_regulation (downregulating) of Gene_expression (expression) of FasL
3) Confidence 0.13 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.07 Pain Relevance 0.03
Consistent with this finding, expression of proinflammatory factors and CD95L that likely induce functional activation and apoptosis of mDC are substantially reduced in SIV- and HIV-infected lymph nodes in response to ART [19], [50], [51].
Negative_regulation (reduced) of Gene_expression (expression) of CD95L in lymph nodes associated with acquired immune deficiency syndrome or hiv infection and apoptosis
4) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.02 Pain Relevance 0

General Comments

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