INT95136

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 8.01
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG)
plasma membrane (FASLG) cell-cell signaling (FASLG)
Anatomy Link Frequency
T cells 2
lymphocyte 1
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 9 98.88 Very High Very High Very High
Migraine 152 98.20 Very High Very High Very High
Chronic pancreatitis 5 97.08 Very High Very High Very High
fibrosis 1 87.40 High High
cytokine 35 84.92 Quite High
Multiple sclerosis 3 84.52 Quite High
Inflammation 7 76.76 Quite High
Arthritis 55 55.00 Quite High
rheumatoid arthritis 4 54.84 Quite High
cINOD 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 54 100.00 Very High Very High Very High
Demyelinating Disease 11 99.76 Very High Very High Very High
Necrosis 8 99.70 Very High Very High Very High
Cancer 10 99.52 Very High Very High Very High
Death 36 99.50 Very High Very High Very High
Pancreatic Cancer 1 98.72 Very High Very High Very High
Migraine Disorders 92 98.20 Very High Very High Very High
Pancreatitis 5 97.08 Very High Very High Very High
Infection 25 96.52 Very High Very High Very High
Lymphopenia 1 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CA repeat polymorphism located, upstream of the FasL gene, has previously been found to be associated with MS, in Spanish and American populations [18].
FasL gene Binding (associated) of associated with demyelinating disease
1) Confidence 0.33 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 1.15 Pain Relevance 0.54
The FasL gene encodes a protein FasL, which interacts with a transmembrane protein of the tumor necrosis factor receptor superfamily to induce apoptosis in susceptible cells [19].
FasL Binding (interacts) of associated with necrosis, cancer and apoptosis
2) Confidence 0.32 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 1.44 Pain Relevance 0.45
The death receptor ligands tumor necrosis factor (TNF), FasL and TNF-related apoptosis-inducing ligand (TRAIL) might be interesting candidates as they are able to induce apoptosis by binding to their cell membrane receptors.
FasL Binding (binding) of associated with necrosis, cancer, apoptosis and death
3) Confidence 0.31 Published 2003 Journal Drugs Today Section Abstract Doc Link 14988748 Disease Relevance 1.01 Pain Relevance 0
This lymphocyte apoptosis is likely to involve several pathways, but we show that apoptosis via Fas/FasL interaction is largely responsible for the massive lymphocyte death observed in human fatal ZEBOV infection.
FasL Binding (interaction) of in lymphocyte associated with apoptosis, infection and death
4) Confidence 0.20 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 1.66 Pain Relevance 0
Additionally, blockade of Fas/FasL interaction by anti-FasL inhibited the morphine-induced production of IL-4 and IL-13 and AICD of CD4(+) T cells.
FasL Binding (interaction) of in T cells associated with death and morphine
5) Confidence 0.16 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.65 Pain Relevance 0.85
In vitro, IFNgamma down-modulated CD95L message and protein in ASPC1 and BxPc3 pancreatic carcinoma cells.
CD95L Binding (message) of associated with pancreatic cancer
6) Confidence 0.16 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11310825 Disease Relevance 0.63 Pain Relevance 0.37
Clonally expanded T cells that have served their functional purpose are also cleared from the system through activation induced cell death (AICD) involving cell surface FasL/Fas receptor interaction [13].
FasL Spec (cleared) Binding (interaction) of in T cells associated with death
7) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.47 Pain Relevance 0.19

General Comments

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