INT95145

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Context Info
Confidence 0.10
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 4.85
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ean5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 44 100.00 Very High Very High Very High
Neuritis 36 100.00 Very High Very High Very High
Inflammation 4 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 36 100.00 Very High Very High Very High
Immunization 12 100.00 Very High Very High Very High
Vibrio Infection 4 99.32 Very High Very High Very High
Demyelinating Disease 4 98.12 Very High Very High Very High
Disease 4 98.08 Very High Very High Very High
INFLAMMATION 4 97.56 Very High Very High Very High
Autoimmune Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously demonstrated that EAN actively induced by immunization with bovine PNS-myelin can be suppressed by feeding of myelin.
Negative_regulation (suppressed) of Positive_regulation (induced) of EAN associated with immunization and neuritis
1) Confidence 0.10 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311326 Disease Relevance 1.20 Pain Relevance 0.98
This myelin-specific oral tolerance (OT) was enhanced by coapplication of cholera toxin (CT).In the present study, EAN induced by immunization with a neuritogenic P2 peptide was completely prevented by precedent feeding of the peptide.
Negative_regulation (prevented) of Positive_regulation (induced) of EAN associated with immunization, tolerance, vibrio infection and neuritis
2) Confidence 0.09 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311326 Disease Relevance 1.22 Pain Relevance 1.02
Adjuvant effects and bystander suppression in P2 peptide-induced EAN.
Negative_regulation (suppression) of Positive_regulation (induced) of EAN associated with neuritis
3) Confidence 0.09 Published 2001 Journal J. Neuroimmunol. Section Title Doc Link 11311326 Disease Relevance 1.27 Pain Relevance 1.10
In contrast to OT by myelin, addition of CT completely prevented oral induction of tolerance to peptide-induced EAN, while adjuvant feeding alone did not modulate disease.
Negative_regulation (prevented) of Positive_regulation (induced) of EAN associated with tolerance, disease and neuritis
4) Confidence 0.09 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311326 Disease Relevance 1.16 Pain Relevance 1.06

General Comments

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