INT9516

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Context Info
Confidence 0.53
First Reported 1981
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 149
Total Number 152
Disease Relevance 27.83
Pain Relevance 91.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 12
brain 7
amygdala 4
eye 3
respiratory 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 2732 100.00 Very High Very High Very High
GABAergic 929 100.00 Very High Very High Very High
agonist 443 100.00 Very High Very High Very High
Neurotransmitter 360 100.00 Very High Very High Very High
Glutamate 266 100.00 Very High Very High Very High
GABA receptor 141 100.00 Very High Very High Very High
Cannabinoid 105 100.00 Very High Very High Very High
Ventral tegmentum 97 100.00 Very High Very High Very High
lidocaine 13 99.98 Very High Very High Very High
antagonist 584 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 51 99.98 Very High Very High Very High
Infection 6 99.96 Very High Very High Very High
Anorexia 14 99.80 Very High Very High Very High
Cv Unclassified Under Development 11 99.80 Very High Very High Very High
Hypoalagesia 9 99.80 Very High Very High Very High
Anxiety Disorder 196 99.62 Very High Very High Very High
Sensorineural Hearing Loss 132 99.60 Very High Very High Very High
Targeted Disruption 251 99.28 Very High Very High Very High
Sprains And Strains 97 99.28 Very High Very High Very High
Pain 136 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that blockade of both GABAA and GABAC receptors is necessary to attenuate GABA inhibition of retinal rhythms with, again, no dependence on GABAB receptors.
Negative_regulation (blockade) of GABAA associated with addiction and gaba
1) Confidence 0.53 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.77
Treatment with THIP (15 mg/kg) was found to block the antinociceptive response to an inhibitor of the uptake of GABA, an inhibitor of GABA-transaminase, a direct-acting GABA receptor agonist and to a cholinesterase inhibitor.
Negative_regulation (inhibitor) of GABA associated with gaba, gaba receptor, agonist and antinociceptive
2) Confidence 0.51 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3037414 Disease Relevance 0 Pain Relevance 0.87
Involvement of GABA in the antinociceptive effect of gamma-acetylenic GABA (GAG), an inhibitor of GABA-transaminase.
Negative_regulation (inhibitor) of GABA associated with gaba, analgesic and antinociceptive
3) Confidence 0.50 Published 1983 Journal Gen. Pharmacol. Section Title Doc Link 6662342 Disease Relevance 0.10 Pain Relevance 1.13
GABAergic control of dopaminergic activity was studied by measuring extracellular GABA in the presence of nipecotic acid, an inhibitor of GABA uptake.
Negative_regulation (inhibitor) of GABA associated with gaba and gabaergic
4) Confidence 0.50 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18786163 Disease Relevance 0 Pain Relevance 1.56
In brain slices, halothane was shown to inhibit the metabolic breakdown of GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter.
Negative_regulation (breakdown) of GABA in brain associated with neurotransmitter, gaba and halothane
5) Confidence 0.46 Published 1981 Journal Anesthesiology Section Abstract Doc Link 6787954 Disease Relevance 0 Pain Relevance 0.56
These results indicate that blockade of both GABAA and GABAC receptors is necessary to attenuate GABA inhibition of retinal rhythms with, again, no dependence on GABAB receptors.
Negative_regulation (inhibition) of GABA associated with addiction and gaba
6) Confidence 0.46 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.74
In addition, we found that the presynaptic inhibition of GABAergic transmission at both GABAA and GABAB receptors was differentially regulated by U69593 between the two groups.
Negative_regulation (inhibition) of GABAA associated with gabaergic
7) Confidence 0.45 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16525058 Disease Relevance 0 Pain Relevance 1.41
As a positive control, the effects of vigabatrin, which irreversibly inhibits GABA transaminase, were also examined.
Negative_regulation (inhibits) of GABA associated with gaba
8) Confidence 0.42 Published 2006 Journal Anesthesiology Section Abstract Doc Link 16871066 Disease Relevance 0 Pain Relevance 0.57
It is concluded that GABA is capable of reducing voltage-dependent sodium currents of distinct neuronal individuals via a GABAA receptor-like structure.
Negative_regulation (reducing) of GABAA in neuronal associated with gaba
9) Confidence 0.42 Published 1994 Journal Brain Res. Section Abstract Doc Link 7850461 Disease Relevance 0 Pain Relevance 0.35
The conditional GABA(B(1)) allele described here is therefore suitable for generating mice with a site- and time-specific loss of GABA(B) function.
Negative_regulation (loss) of GABA associated with gaba
10) Confidence 0.42 Published 2004 Journal Genesis Section Abstract Doc Link 15493018 Disease Relevance 0.37 Pain Relevance 0.66
In addition, several anesthetics have been shown to reduce desensitization of GABAA receptors [28,29] (Fig. 2A and B).
Negative_regulation (desensitization) of GABAA
11) Confidence 0.42 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908224 Disease Relevance 0 Pain Relevance 0.50
Significant and long-lasting decreases in steady state YGG levels were elicited by muscimol, a gamma-aminobutyric acid-A (GABAA) receptor agonist, diazepam, a benzodiazepine receptor agonist, or aminooxyacetic acid, a GABA-transaminase inhibitor.
Negative_regulation (inhibitor) of GABAA associated with gaba and agonist
12) Confidence 0.42 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.68
Inhibition of GABAA receptor-mediated current responses by enoxacin (new quinolone) and felbinac (non-steroidal anti-inflammatory drug) in Xenopus oocytes injected with mouse-brain messenger RNA.
Negative_regulation (Inhibition) of GABAA in oocytes associated with inflammation
13) Confidence 0.42 Published 1993 Journal Biol. Pharm. Bull. Section Title Doc Link 7691340 Disease Relevance 0.27 Pain Relevance 0.33
Nonetheless, blockade of GABAA receptors during subthreshold responses decreases the synaptic potential in D1-SP+ MSNs since a depolarizing component: inhibition, was blocked (colored trace in Figure 3A).
Negative_regulation (blockade) of GABAA associated with projection neuron and substance p
14) Confidence 0.41 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.49
Addition of NCPA further decreased GABAAergic sIPSC frequency to 0.2 ± 0.1 Hz (Mann-Whitney Rank Sum Test, P = 0.041), and decreased sEPSC frequency to 2.0 ± 1.2 Hz (n = 6, Two Sample t-test, P = 0.035).


Negative_regulation (decreased) of GABAA
15) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0
All experiments measuring the I–V relationship were carried out in the presence of picrotoxin (100 µM) and D,L-APV (100 µM) in order to block GABAA and NMDA receptors, respectively.
Negative_regulation (block) of GABAA associated with nmda receptor
16) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013137 Disease Relevance 0 Pain Relevance 0.15
The inhibitors of GABA-transaminase, amino-oxyacetic acid, gamma-acetylenic GABA and gamma-vinyl GABA, produced analgesia which was much more prolonged than that observed with muscimol, baclofen or morphine.
Negative_regulation (inhibitors) of GABA associated with gaba, morphine and analgesia
17) Confidence 0.41 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 7110528 Disease Relevance 0 Pain Relevance 1.33
After ICV injection of GABA, blockade of GABA(A) receptors with bicuculline (0.2 mg/kg) did not prevent the hypoxic hyperventilation.
Negative_regulation (blockade) of GABA associated with gaba, hypoxia, dyspnea and intracerebroventricular
18) Confidence 0.41 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15240932 Disease Relevance 1.24 Pain Relevance 0.93
Analgesia produced by baclofen, morphine and inhibitors of GABA-transaminase may involve another class of GABA receptors which are insensitive to bicuculline.
Negative_regulation (inhibitors) of GABA associated with gaba, gaba receptor, morphine and analgesia
19) Confidence 0.40 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 7110528 Disease Relevance 0 Pain Relevance 1.65
Additionally, a recently generated parvalbumin-Cre mouse (Hippenmeyer et al., 2005) can be used to genetically label parvalbumin-positive neurons for in vivo calcium imaging experiments, thereby restricting analysis to a particular class of inhibitory cells while avoiding the confound of reduced GABA levels in GAD67-GFP knock-in mice (Tamamaki et al., 2003; Gandhi et al., 2008).
Negative_regulation (reduced) of GABA in neurons associated with targeted disruption, gaba and imagery
20) Confidence 0.40 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893754 Disease Relevance 0.10 Pain Relevance 0.14

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