INT95161

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.01
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ncam1) aging (Ncam1) cell adhesion (Ncam1)
plasma membrane (Ncam1)
Anatomy Link Frequency
neural 3
neurons 1
extracellular matrix 1
heart 1
Ncam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 18 100.00 Very High Very High Very High
gABA 2 97.72 Very High Very High Very High
Nerve growth factor 5 93.48 High High
Glutamate receptor 2 92.64 High High
tetrodotoxin 2 91.56 High High
Spinal cord 85 90.04 High High
Serotonin 1 79.92 Quite High
sodium channel 2 75.84 Quite High
Pain 4 50.00 Quite Low
medulla 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 15 100.00 Very High Very High Very High
Spinal Cord Injury 55 90.32 High High
Pain 4 73.92 Quite High
Endometriosis 2 73.72 Quite High
Hypertension 18 69.44 Quite High
Coronary Heart Disease 3 62.80 Quite High
Metaplasia 1 50.00 Quite Low
Heart Rate Under Development 26 44.16 Quite Low
Injury 64 40.08 Quite Low
Sprains And Strains 18 36.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study examines translocation of polysialylated neural cell adhesion molecule (PSA-NCAM), a negative regulator of cell adhesion, in cells of the rat hypothalamo-neurohypophysial system in which it is expressed throughout life and which undergo morphological remodelling in response to stimulation.
Spec (examines) Localization (translocation) of NCAM in neural associated with adhesions
1) Confidence 0.80 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311794 Disease Relevance 0.37 Pain Relevance 0
In contrast, PSA-NCAM surface translocation was inhibited reversibly by cooling the cultures at 20 degrees C, a procedure which blocks constitutive secretion and which resulted in accumulation of PSA-NCAM in the cytoplasm of oxytocinergic and non-oxytocinergic neurons.
Localization (translocation) of NCAM in neurons
2) Confidence 0.70 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311794 Disease Relevance 0.07 Pain Relevance 0.19
INTERVENTION(S): Immunohistochemical staining of endometriotic specimens for alpha-smooth muscle actin (ASMA), neural cell adhesion molecule (NCAM), and nerve growth factor (NGF) expression.
Localization (staining) of NCAM in neural
3) Confidence 0.56 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18930216 Disease Relevance 0.15 Pain Relevance 0
Ten of the genes investigated (Bace1, Timm8b, Ncam1, Slc37a4, Cul5, Fxyd2, Fxyd6, Ptpn9, Scamp2 and Scamp5) did not display any association with the heart rate trait and were eliminated.
Neg (not) Localization (eliminated) of Ncam1 in heart
4) Confidence 0.42 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1865373 Disease Relevance 0.13 Pain Relevance 0.08
Neural cell adhesion molecule (NCAM) in the repaired sciatic nerve
Localization (sciatic nerve) of NCAM in Neural associated with sciatic nerve and adhesions
5) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.10 Pain Relevance 0.05
SCs promote axonal regeneration by secretion of adhesion molecules such as L1 and N-CAM, extracellular matrix molecules such as collagen [72] and laminin (see Chernousov and Carey [73] for review), and a number of trophic factors such as FGF-2 [74], nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and NT3 (see Mirsky et al [75] for review).
Localization (secretion) of N-CAM in extracellular matrix associated with nerve growth factor and adhesions
6) Confidence 0.14 Published 2007 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1876804 Disease Relevance 0.19 Pain Relevance 0.14

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