INT95163

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.02
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ncam1) aging (Ncam1) cell adhesion (Ncam1)
plasma membrane (Ncam1)
Anatomy Link Frequency
nerve 2
heart 1
Schwann cells 1
Ncam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 68 86.52 High High
unmyelinated 4 76.24 Quite High
Serotonin 1 76.24 Quite High
sodium channel 2 72.16 Quite High
tetrodotoxin 1 65.92 Quite High
Pain 8 64.64 Quite High
Glutamate receptor 1 64.32 Quite High
Spinal cord 40 59.64 Quite High
gABA 1 52.96 Quite High
dorsal root ganglion 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 88 99.14 Very High Very High Very High
Adhesions 20 84.68 Quite High
Hypertension 18 65.76 Quite High
Pain 8 64.64 Quite High
Coronary Heart Disease 3 59.12 Quite High
Heart Rate Under Development 19 40.48 Quite Low
Nervous System Injury 20 33.76 Quite Low
Sprains And Strains 18 32.64 Quite Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the cultures, immunoreaction for PSA-NCAM was visible on the surface of oxytocinergic and non-oxytocinergic axons.
NCAM Binding (immunoreaction) of
1) Confidence 0.32 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311794 Disease Relevance 0.27 Pain Relevance 0.12
Ten of the genes investigated (Bace1, Timm8b, Ncam1, Slc37a4, Cul5, Fxyd2, Fxyd6, Ptpn9, Scamp2 and Scamp5) did not display any association with the heart rate trait and were eliminated.
Ncam1 Binding (association) of in heart
2) Confidence 0.21 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1865373 Disease Relevance 0.12 Pain Relevance 0.07
Neurofilament stained axons were only partly associated with NCAM stained areas of Schwann cells after immediate repair, while after repair at 90 and 180 days post injury almost all regenerating nerve fibers were associated with NCAM stained Schwann cells (Fig. 3d, e, f).
NCAM Binding (associated) of in Schwann cells associated with injury
3) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.17 Pain Relevance 0.09
The latter findings point towards a more prominent regeneration of non-myelinated axons after a delayed nerve repair, since NCAM (and L1) is associated with non-myelinating Schwann cells and not myelinating Schwann cells [18,20].
NCAM Binding (associated) of in nerve
4) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.30 Pain Relevance 0.13
In contralateral control nerves only patchy areas of NCAM staining were seen and large diameter nerve fibres were not associated with NCAM (Figure 3c).
NCAM Binding (associated) of in nerve
5) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.08 Pain Relevance 0.04
In ten days after transection and immediate repair neurofilament stained fibres with positive NCAM staining had increased, but fibres not associated with NCAM were still seen (Figure 3d).
NCAM Binding (associated) of
6) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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