INT95164

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 6.06
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NCAM1) cell adhesion (NCAM1) plasma membrane (NCAM1)
Anatomy Link Frequency
NK cells 2
primary sensory neurons 2
neural 2
neuronal 1
leukocytes 1
NCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
trigeminal ganglion 90 99.96 Very High Very High Very High
cytokine 19 99.36 Very High Very High Very High
Acupuncture 182 97.28 Very High Very High Very High
medulla 78 96.08 Very High Very High Very High
Dorsal horn 6 95.12 Very High Very High Very High
Arthritis 54 95.00 High High
spondylitis 7 94.68 High High
Spinal cord 12 94.64 High High
ischemia 6 84.28 Quite High
cerebral cortex 6 80.08 Quite High
Disease Link Frequency Relevance Heat
Adhesions 30 100.00 Very High Very High Very High
Ganglion Cysts 114 99.96 Very High Very High Very High
Chronic Fatigue Syndrome 78 96.64 Very High Very High Very High
Polycystic Ovary Syndrome 1 95.76 Very High Very High Very High
Arthritis 60 95.00 High High
Low Back Pain 8 94.68 High High
Cancer 66 92.44 High High
Pressure And Volume Under Development 9 89.56 High High
Adenofibroma 3 85.52 High High
Brain Injury 6 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD56brightCD16neg NK cells preferentially secrete high levels of cytokines and have limited cytotoxic function while CD56dimCD16pos NK cells are mainly cytotoxic [11].
Localization (secrete) of CD56 in NK cells associated with cytokine
1) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 1.33 Pain Relevance 0.23
Studies in the fetal brain focus on the localization of PSA-NCAM in discrete forebrain regions and on its role in developmental processes, such as neuronal migration and transitory axonal projections [27], and onset of myelination [28].
Localization (localization) of PSA-NCAM in neuronal
2) Confidence 0.73 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.39 Pain Relevance 0.12
The localization of PSA-NCAM to the caudal part of the trigeminal spinal sensory nucleus and its changes with age are consistent with data on the rat dorsal horn spinal cord showing that PSA-NCAM is more widely expressed during embryonic and early postnatal than in adult life, when it is confined to the superficial laminae [42,43].
Localization (localization) of PSA-NCAM in caudal part associated with dorsal horn and spinal cord
3) Confidence 0.73 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.17 Pain Relevance 0.23
The study has been carried out by immunohistochemistry on normal tissue and conveys data on the occurrence of PSA-NCAM immunoreactivity in those regions at prenatal, neonatal and adult age.
Localization (occurrence) of PSA-NCAM
4) Confidence 0.69 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.19 Pain Relevance 0.21
In particular, the localization of PSA-NCAM in TG primary sensory neurons likely to be involved in the transmission of protopathic stimuli suggests the possible participation of this molecule in the processing of the relevant sensory neurotransmission.



Localization (localization) of PSA-NCAM in primary sensory neurons associated with trigeminal ganglion
5) Confidence 0.64 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2612005 Disease Relevance 0.25 Pain Relevance 0.19
The localization of PSA-NCAM in primary sensory neurons likely to be involved in the transmission of protopathic stimuli bears a specific significance as it suggests the possible participation of this molecule in the processing of the relevant sensory neurotransmission.


Localization (localization) of PSA-NCAM in primary sensory neurons
6) Confidence 0.64 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.13 Pain Relevance 0.17
A significant increase was found in CD56+ CD16+ (P < or = 0.009), and also in the subset of CD56 dim CD16+ (P < or = 0.02), but not in CD56 bright CD16+ (P=0.3) NK cells in AS patients compared to controls.
Neg (not) Localization (found) of CD56 in NK cells associated with spondylitis
7) Confidence 0.61 Published 2009 Journal Iran J Allergy Asthma Immunol Section Abstract Doc Link 20404389 Disease Relevance 0.73 Pain Relevance 0.38
PSA-NCAM is localized to neuronal perikarya, nerve fibres in bundles and in between neurons, and satellite and Schwann cells; further, intense cytoplasmic staining and networks of positive pericellular fibres occur in adult tissue and are detectable only occasionally in the newborn one (Figures 2, 3).
Localization (localized) of PSA-NCAM in neurons
8) Confidence 0.60 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.10 Pain Relevance 0.12
Phenotyping of the final products showed a patient-specific prevalence of NKT CD16+CD56+CD3+ (patient #1) or of NK CD16+CD56+CD3- (patients #2 and #3) cells.
Localization (prevalence) of CD56
9) Confidence 0.39 Published 2006 Journal J Transl Med Section Body Doc Link PMC1681349 Disease Relevance 0.05 Pain Relevance 0
INTERVENTION(S): Immunohistochemical staining of endometriotic specimens for alpha-smooth muscle actin (ASMA), neural cell adhesion molecule (NCAM), and nerve growth factor (NGF) expression.
Localization (staining) of neural cell adhesion molecule in neural
10) Confidence 0.29 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18930216 Disease Relevance 0.15 Pain Relevance 0
Bee venom decreased numbers of white blood cells, infiltration of leukocytes and fibroblasts into synovial joints, CD56, IL-1 ?
Localization (infiltration) of CD56 in fibroblasts
11) Confidence 0.18 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062163 Disease Relevance 0.54 Pain Relevance 0.48
Immunihistochemically, the minor sex cord elements are positive for inhibin, calretinin, CD99, CD56, antikeratin antibody KL1 and MIC. [2,6]
Localization (calretinin) of CD56
12) Confidence 0.09 Published 2008 Journal Cases J Section Body Doc Link PMC2579288 Disease Relevance 1.14 Pain Relevance 0
Bee venom decreased numbers of white blood cells, infiltration of leukocytes and fibroblasts into synovial joints, CD56, IL-1 ?
Localization (infiltration) of CD56 in leukocytes
13) Confidence 0.06 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062163 Disease Relevance 0.54 Pain Relevance 0.48
The present study examines translocation of polysialylated neural cell adhesion molecule (PSA-NCAM), a negative regulator of cell adhesion, in cells of the rat hypothalamo-neurohypophysial system in which it is expressed throughout life and which undergo morphological remodelling in response to stimulation.
Spec (examines) Localization (translocation) of neural cell adhesion molecule in neural associated with adhesions
14) Confidence 0.06 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311794 Disease Relevance 0.37 Pain Relevance 0

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