INT95167

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 26.72
Pain Relevance 21.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRGX)
Anatomy Link Frequency
neurons 10
DRG 8
spinal cord 2
neuronal 2
macrophages 1
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 354 100.00 Very High Very High Very High
dorsal root ganglion 347 100.00 Very High Very High Very High
GCH1 56 100.00 Very High Very High Very High
hyperexcitability 14 99.96 Very High Very High Very High
Neuronal excitability 7 99.96 Very High Very High Very High
Pain 490 99.92 Very High Very High Very High
Spinal cord 105 99.76 Very High Very High Very High
chemokine 13 99.66 Very High Very High Very High
Eae 22 99.10 Very High Very High Very High
Dorsal horn 38 98.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 374 100.00 Very High Very High Very High
Ganglion Cysts 365 100.00 Very High Very High Very High
Nervous System Injury 104 100.00 Very High Very High Very High
Injury 76 100.00 Very High Very High Very High
Pain 522 99.92 Very High Very High Very High
Nociception 232 99.42 Very High Very High Very High
Erythermalgia 136 98.84 Very High Very High Very High
Demyelinating Disease 5 98.72 Very High Very High Very High
Neuropathic Pain 372 98.40 Very High Very High Very High
Arthritis 162 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here that the intensity and distribution pattern of [(3)H] pregabalin binding is altered in the ipsilateral dorsal horn following CCI and this is associated with a corresponding increase in alpha 2 delta 1 mRNA in the ipsilateral dorsal root ganglion (DRG).
Positive_regulation (increase) of DRG in DRG associated with ganglion cysts, dorsal root ganglion, pregabalin, eae and dorsal horn
1) Confidence 0.22 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17367933 Disease Relevance 0.92 Pain Relevance 1.17
We evaluated the promotion of axonal growth and SP induction of DRG neurons in extracted medium from the NP and AF using immunocytochemistry.
Positive_regulation (induction) of DRG in DRG
2) Confidence 0.13 Published 2009 Journal Spine Section Body Doc Link 19934806 Disease Relevance 0.07 Pain Relevance 0
The presence of vanilloid receptor-1 in DRG neurons makes their mitochondria 20-30-fold more sensitive to the depolarising effect of capsaicin compared with non-neuronal cells lacking vanilloid receptor-1.
Positive_regulation (presence) of DRG in neurons associated with dorsal root ganglion and qutenza
3) Confidence 0.12 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311802 Disease Relevance 0.62 Pain Relevance 1.18
However, Harty et al [13,16,17] have shown that depolarization of RMP produced by an IEM mutation (A863P) contributes to, but is not solely responsible for, the increase in DRG neuron hyperexcitability produced by that mutation.
Positive_regulation (increase) of DRG neuron in neuron associated with dorsal root ganglion, erythermalgia and hyperexcitability
4) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.99 Pain Relevance 0.96
Pancreatic cancer cell supernatants induced a prominent neurite outgrowth, increased neurite density and perikaryonal hypertrophy in MP and DRG neurons.
Positive_regulation (induced) of DRG in neurons
5) Confidence 0.06 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 19912545 Disease Relevance 0 Pain Relevance 0
Our data also show that both mutants produce larger ramp currents and increase DRG neuronal excitability, which provides a cellular basis for pain in patients carrying these IEM and PEPD mutations.
Positive_regulation (increase) of DRG in neuronal associated with pain, dorsal root ganglion, neuronal excitability, paroxysmal extreme pain disorder and erythermalgia
6) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.80 Pain Relevance 0.51
We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG.
Positive_regulation (increased) of DRG in sensory neurons associated with ganglion cysts and dorsal root ganglion
7) Confidence 0.05 Published 2007 Journal BMC Neurol Section Abstract Doc Link PMC1892784 Disease Relevance 0.81 Pain Relevance 0.36
In summary, the present study shows that the V1298F (PEPD) and P1308L (IEM) mutations, both substituting single amino acids within the DIII/S4-S5 linker of NaV1.7 channel, increase DRG neuronal excitability by affecting different biophysical properties of NaV1.7.
Positive_regulation (increase) of DRG in neuronal associated with dorsal root ganglion, neuronal excitability, paroxysmal extreme pain disorder and erythermalgia
8) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.79 Pain Relevance 0.63
The ability of both types of mutation to induce DRG neuron hyperexcitability is in agreement with our previous findings of a similar effect of other IEM and PEPD mutations [5,6,18,19,24,26], and provides a cellular basis for pain in patients carrying these mutations.
Positive_regulation (induce) of DRG in neuron associated with pain, dorsal root ganglion, paroxysmal extreme pain disorder, erythermalgia and hyperexcitability
9) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.78 Pain Relevance 0.64
It has recently been shown that several disease-causing erythromelalgia mutations alter channel-gating behavior in a manner that increases DRG neuron excitability.


Positive_regulation (increases) of DRG in neuron associated with erythermalgia and disease
10) Confidence 0.04 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1781932 Disease Relevance 1.02 Pain Relevance 0.71
By contrast, in DRG from rats (n = 5) in which the inflammation had been induced on the ipsilateral side three days previously, a much higher proportion of DRG neurons of both sides exhibited grey values of more than 0.16, indicating binding of SP–gold (Fig. 5d).
Positive_regulation (induced) of DRG in neurons associated with dorsal root ganglion, inflammation and substance p
11) Confidence 0.04 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.98 Pain Relevance 0.89
TRPV1 expression levels in the ipsilateral cervical DRG were also elevated after forepaw inflammation.
Positive_regulation (elevated) of DRG in DRG associated with inflammation
12) Confidence 0.03 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17509082 Disease Relevance 1.41 Pain Relevance 0.81
By contrast, HPL at 56 degrees C was not shortened after forepaw inflammation and expression of TRPV2, a TRPV1 homolog, in the DRG was not increased.
Neg (not) Positive_regulation (increased) of DRG in DRG associated with inflammation
13) Confidence 0.03 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17509082 Disease Relevance 1.60 Pain Relevance 0.91
Paratracheal injection of short interfering RNA targeting TRPV1 blocked TRPV1 up-regulation in cervical DRG and abolished inflammation-mediated HPL reductions seen at 50 degrees C.
Positive_regulation (up-regulation) of DRG in DRG associated with inflammation
14) Confidence 0.03 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17509082 Disease Relevance 1.63 Pain Relevance 0.99
A congener of SNAP lacking the releasable NO group (NAP: N-acetylpenicillamine; 3 mM) did not activate DRG neurons, consistent with NO-dependent activation (Fig. 1C).
Neg (not) Positive_regulation (activate) of DRG in neurons
15) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0.12 Pain Relevance 0.22
We confirmed that NO donor activates DRG neurons in a cGMP-independent manner using the membrane-permeable cGMP analogue pCPT-cGMP (8-(4-Chlorophenylthio)-guanosine 3?
Positive_regulation (activates) of DRG in neurons
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.11
In this study we found that overnight incubation with GRO/KC (CXCL1), a chemokine that is rapidly upregulated in the DRG in several different models of chronic pain, caused increased excitability and marked upregulation of Na+ current amplitudes in acutely isolated small diameter DRG neurons in short-term culture.
Positive_regulation (upregulated) of DRG in neurons associated with chemokine and lasting pain
17) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.30 Pain Relevance 0.30
However, the most potent upregulation occurs in the DRG following peripheral nerve axotomy when galanin is rapidly up-regulated by up to 120-fold and is expressed in 40-50% of sensory neurons [14].
Positive_regulation (occurs) of DRG in DRG
18) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 1.05 Pain Relevance 0.60
However, the most potent upregulation occurs in the DRG following peripheral nerve axotomy when galanin is rapidly up-regulated by up to 120-fold and is expressed in 40-50% of sensory neurons [14].
Positive_regulation (upregulation) of DRG in DRG
19) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 1.05 Pain Relevance 0.61
Recent studies show that transcriptional activation of GTP cyclohydrolase I (GCH1) in dorsal root ganglia (DRG) is significantly involved in the development and persistency of pain symptoms.
Positive_regulation (activation) of DRG in DRG associated with pain and gch1
20) Confidence 0.01 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785765 Disease Relevance 0.32 Pain Relevance 0.52

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